product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse/Rat RAGE Antibody
catalog :
MAB1179-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
499 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
175410
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100
Pribluda A, Daemen A, Lima A, Wang X, Hafner M, Poon C, et al. EHMT2 methyltransferase governs cell identity in the lung and is required for KRAS G12D tumor development and propagation. elife. 2022;11: pubmed publisher
  • western blot; mouse; 2 ug/ml; loading ...; fig 1f
Li M, Ong C, Langou xeb t Astri xe9 C, Tan L, Verma A, Yang Y, et al. Heparan sulfate-dependent RAGE oligomerization is indispensable for pathophysiological functions of RAGE. elife. 2022;11: pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig s4c
Liberti D, Kremp M, Liberti W, Penkala I, Li S, Zhou S, et al. Alveolar epithelial cell fate is maintained in a spatially restricted manner to promote lung regeneration after acute injury. Cell Rep. 2021;35:109092 pubmed publisher
Wang J, Michki S, Sitaraman S, Banaschewski B, Jamal R, Gokey J, et al. Dysregulated alveolar epithelial cell progenitor function and identity in Hermansky-Pudlak syndrome. JCI Insight. 2024;10: pubmed publisher
Warren R, Klinkhammer K, Lyu H, Knopp J, Yuan T, Yao C, et al. Cell competition drives bronchiolization and pulmonary fibrosis. Nat Commun. 2024;15:10624 pubmed publisher
Spurgin S, Nguimtsop A, Chaudhry F, Michki S, Salvador J, Iruela Arispe M, et al. Spatiotemporal dynamics of primary and motile cilia throughout lung development. bioRxiv. 2024;: pubmed publisher
He H, Bell S, Davis A, Zhao S, Sridharan A, Na C, et al. PRDM3/16 regulate chromatin accessibility required for NKX2-1 mediated alveolar epithelial differentiation and function. Nat Commun. 2024;15:8112 pubmed publisher
Lv Z, Liu Z, Liu K, Lin X, Pu W, Li Y, et al. Alveolar regeneration by airway secretory-cell-derived p63+ progenitors. Cell Stem Cell. 2024;31:1685-1700.e6 pubmed publisher
Clarke D, Curtis K, Wendt R, Stapley B, Clark E, Beckett N, et al. Decreased Expression of Pulmonary Homeobox NKX2.1 and Surfactant Protein C in Developing Lungs That Over-Express Receptors for Advanced Glycation End-Products (RAGE). J Dev Biol. 2023;11: pubmed publisher
Kaiser A, Gatto A, Hanson K, Zhao R, Raj N, Ozawa M, et al. p53 governs an AT1 differentiation programme in lung cancer suppression. Nature. 2023;619:851-859 pubmed publisher
Juul N, Yoon J, Martinez M, Rishi N, Kazadaeva Y, Morri M, et al. KRAS(G12D) drives lepidic adenocarcinoma through stem-cell reprogramming. Nature. 2023;619:860-867 pubmed publisher
Warren R, Lyu H, Klinkhammer K, De Langhe S. Hippo signaling impairs alveolar epithelial regeneration in pulmonary fibrosis. elife. 2023;12: pubmed publisher
Cardenas Diaz F, Liberti D, Leach J, Babu A, Barasch J, Shen T, et al. Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1. Cell Rep. 2023;42:112451 pubmed publisher
Li Q, Qiao Y, Wang F, Zhao J, Wu L, Ge H, et al. Prenatal triclosan exposure impairs mammalian lung branching morphogenesis through activating Bmp4 signaling. Ecotoxicol Environ Saf. 2023;256:114896 pubmed publisher
Han Z, Andr x161 M, Madhavan B, Kaymak S, Sulaj A, Kender Z, et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Res. 2023;51:2298-2318 pubmed publisher
Allg xe4 uer L, Cabungcal J, Yzydorczyk C, Do K, Dwir D. Low protein-induced intrauterine growth restriction as a risk factor for schizophrenia phenotype in a rat model: assessing the role of oxidative stress and neuroinflammation interaction. Transl Psychiatry. 2023;13:30 pubmed publisher
Weiner A, Zhao G, Zayas H, Holcomb N, Adams Tzivelekidis S, Wong J, et al. ΔNp63 drives dysplastic alveolar remodeling and restricts epithelial plasticity upon severe lung injury. Cell Rep. 2022;41:111805 pubmed publisher
Kim S, Kim J, Jang J, Noh H, Park J, Jeong H, et al. Mouse models of lung-specific SARS-CoV-2 infection with moderate pathological traits. Front Immunol. 2022;13:1055811 pubmed publisher
Brownfield D, de Arce A, Ghelfi E, Gillich A, Desai T, Krasnow M. Alveolar cell fate selection and lifelong maintenance of AT2 cells by FGF signaling. Nat Commun. 2022;13:7137 pubmed publisher
Jeong H, Woo Lee Y, Park I, Noh H, Kim S, Kim J, et al. Comparison of the pathogenesis of SARS-CoV-2 infection in K18-hACE2 mouse and Syrian golden hamster models. Dis Model Mech. 2022;15: pubmed publisher
Konkimalla A, Konishi S, Kobayashi Y, Kadur Lakshminarasimha Murthy P, Macadlo L, Mukherjee A, et al. Multi-apical polarity of alveolar stem cells and their dynamics during lung development and regeneration. iScience. 2022;25:105114 pubmed publisher
Chen S, Zhang X, Yang C, Wang S, Shen H. Essential role of IL-17 in acute exacerbation of pulmonary fibrosis induced by non-typeable Haemophilus influenzae. Theranostics. 2022;12:5125-5137 pubmed publisher
Konishi S, Tata A, Tata P. Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures. STAR Protoc. 2022;3:101447 pubmed publisher
Shue Y, Drainas A, Li N, Pearsall S, Morgan D, Sinnott Armstrong N, et al. A conserved YAP/Notch/REST network controls the neuroendocrine cell fate in the lungs. Nat Commun. 2022;13:2690 pubmed publisher
Jeon H, Choi J, Kraaier L, Kim Y, Eisenbarth D, Yi K, et al. Airway secretory cell fate conversion via YAP-mTORC1-dependent essential amino acid metabolism. EMBO J. 2022;41:e109365 pubmed publisher
Liu J, Zhu S, Zeng L, Li J, Klionsky D, Kroemer G, et al. DCN released from ferroptotic cells ignites AGER-dependent immune responses. Autophagy. 2021;:1-14 pubmed publisher
Gkatzis K, Panza P, Peruzzo S, Stainier D. Differentiation of mouse fetal lung alveolar progenitors in serum-free organotypic cultures. elife. 2021;10: pubmed publisher
Lee C, Kim K, Lee D, Lee S, Kim S. Overexpression of the receptor for advanced glycation end-products in the auditory cortex of rats with noise-induced hearing loss. BMC Neurosci. 2021;22:38 pubmed publisher
Chen Q, Liu Y. Isolation and culture of mouse alveolar type II cells to study type II to type I cell differentiation. STAR Protoc. 2021;2:100241 pubmed publisher
Lee C, Kim K, Lee S, Kim S. Dose-Dependent Effects of Resveratrol on Cisplatin-Induced Hearing Loss. Int J Mol Sci. 2020;22: pubmed publisher
Zhao G, Weiner A, Neupauer K, De Mello Costa M, Palashikar G, Adams Tzivelekidis S, et al. Regeneration of the pulmonary vascular endothelium after viral pneumonia requires COUP-TF2. Sci Adv. 2020;6: pubmed publisher
Katsura H, Sontake V, Tata A, Kobayashi Y, Edwards C, Heaton B, et al. Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction. Cell Stem Cell. 2020;27:890-904.e8 pubmed publisher
Cassandras M, Wang C, Kathiriya J, Tsukui T, Matatia P, Matthay M, et al. Gli1+ mesenchymal stromal cells form a pathological niche to promote airway progenitor metaplasia in the fibrotic lung. Nat Cell Biol. 2020;22:1295-1306 pubmed publisher
Kobayashi Y, Tata A, Konkimalla A, Katsura H, Lee R, Ou J, et al. Persistence of a regeneration-associated, transitional alveolar epithelial cell state in pulmonary fibrosis. Nat Cell Biol. 2020;22:934-946 pubmed publisher
Chen Q, Rehman J, Chan M, Fu P, Dudek S, Natarajan V, et al. Angiocrine Sphingosine-1-Phosphate Activation of S1PR2-YAP Signaling Axis in Alveolar Type II Cells Is Essential for Lung Repair. Cell Rep. 2020;31:107828 pubmed publisher
Vila Ellis L, Cain M, Hutchison V, Flodby P, Crandall E, Borok Z, et al. Epithelial Vegfa Specifies a Distinct Endothelial Population in the Mouse Lung. Dev Cell. 2020;52:617-630.e6 pubmed publisher
Kathiriya J, Brumwell A, Jackson J, Tang X, Chapman H. Distinct Airway Epithelial Stem Cells Hide among Club Cells but Mobilize to Promote Alveolar Regeneration. Cell Stem Cell. 2020;26:346-358.e4 pubmed publisher
Sun T, Huang Z, Zhang H, Posner C, Jia G, Ramalingam T, et al. TAZ is required for lung alveolar epithelial cell differentiation after injury. JCI Insight. 2019;5: pubmed publisher
Katsura H, Kobayashi Y, Tata P, Hogan B. IL-1 and TNFα Contribute to the Inflammatory Niche to Enhance Alveolar Regeneration. Stem Cell Reports. 2019;12:657-666 pubmed publisher
Dwir D, Giangreco B, Xin L, Tenenbaum L, Cabungcal J, Steullet P, et al. MMP9/RAGE pathway overactivation mediates redox dysregulation and neuroinflammation, leading to inhibitory/excitatory imbalance: a reverse translation study in schizophrenia patients. Mol Psychiatry. 2019;: pubmed publisher
Yin W, Kim H, Wang S, Gunawan F, Li R, Buettner C, et al. Fibrillin-2 is a key mediator of smooth muscle extracellular matrix homeostasis during mouse tracheal tubulogenesis. Eur Respir J. 2019;53: pubmed publisher
Chung M, Hogan B. Ager-CreERT2: A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
Kato K, Diéguez Hurtado R, Park D, Hong S, Kato Azuma S, Adams S, et al. Pulmonary pericytes regulate lung morphogenesis. Nat Commun. 2018;9:2448 pubmed publisher
Kim H, Wang X, Kang R, Tang D, Boone B, Zeh H, et al. RAGE-specific single chain Fv for PET imaging of pancreatic cancer. PLoS ONE. 2018;13:e0192821 pubmed publisher
Nagendran M, Riordan D, Harbury P, Desai T. Automated cell-type classification in intact tissues by single-cell molecular profiling. elife. 2018;7: pubmed publisher
Li X, Gao Z, Gao H, Li B, Peng T, Jiang B, et al. Nephrin loss is reduced by grape seed proanthocyanidins in the experimental diabetic nephropathy rat model. Mol Med Rep. 2017;16:9393-9400 pubmed publisher
Matsumoto H, Matsumoto N, Shimazaki J, Nakagawa J, Imamura Y, Yamakawa K, et al. Therapeutic Effectiveness of Anti-RAGE Antibody Administration in a Rat Model of Crush Injury. Sci Rep. 2017;7:12255 pubmed publisher
Lechner A, Driver I, Lee J, Conroy C, Nagle A, Locksley R, et al. Recruited Monocytes and Type 2 Immunity Promote Lung Regeneration following Pneumonectomy. Cell Stem Cell. 2017;21:120-134.e7 pubmed publisher
Kanegai C, Xi Y, Donne M, Gotts J, Driver I, Amidzic G, et al. Persistent Pathology in Influenza-Infected Mouse Lungs. Am J Respir Cell Mol Biol. 2016;55:613-615 pubmed
Yang J, Hernandez B, Martinez Alanis D, Narvaez Del Pilar O, Vila Ellis L, Akiyama H, et al. The development and plasticity of alveolar type 1 cells. Development. 2016;143:54-65 pubmed publisher
Alanis D, Chang D, Akiyama H, Krasnow M, Chen J. Two nested developmental waves demarcate a compartment boundary in the mouse lung. Nat Commun. 2014;5:3923 pubmed publisher
Desai T, Brownfield D, Krasnow M. Alveolar progenitor and stem cells in lung development, renewal and cancer. Nature. 2014;507:190-4 pubmed publisher
Chang D, Martinez Alanis D, Miller R, Ji H, Akiyama H, McCrea P, et al. Lung epithelial branching program antagonizes alveolar differentiation. Proc Natl Acad Sci U S A. 2013;110:18042-51 pubmed publisher
Metz V, Kojro E, Rat D, Postina R. Induction of RAGE shedding by activation of G protein-coupled receptors. PLoS ONE. 2012;7:e41823 pubmed publisher
Mizumoto S, Takahashi J, Sugahara K. Receptor for advanced glycation end products (RAGE) functions as receptor for specific sulfated glycosaminoglycans, and anti-RAGE antibody or sulfated glycosaminoglycans delivered in vivo inhibit pulmonary metastasis of tumor cells. J Biol Chem. 2012;287:18985-94 pubmed publisher
Hallam K, Li Q, Ananthakrishnan R, Kalea A, Zou Y, Vedantham S, et al. Aldose reductase and AGE-RAGE pathways: central roles in the pathogenesis of vascular dysfunction in aging rats. Aging Cell. 2010;9:776-84 pubmed publisher
Zhang H, Tasaka S, Shiraishi Y, Fukunaga K, Yamada W, Seki H, et al. Role of soluble receptor for advanced glycation end products on endotoxin-induced lung injury. Am J Respir Crit Care Med. 2008;178:356-62 pubmed publisher
Parmley L, Elkins N, Fini M, Liu Y, Repine J, Wright R. Alpha-4/beta-1 and alpha-L/beta-2 integrins mediate cytokine induced lung leukocyte-epithelial adhesion and injury. Br J Pharmacol. 2007;152:915-29 pubmed
product information
master code :
MAB1179
SKU :
MAB1179-100
product name :
Mouse/Rat RAGE Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Mouse/Rat RAGE Antibody from R&D Systems is a rat monoclonal antibody to AGER. This antibody reacts with hamster,human,mouse,rat,transgenic mouse. The Mouse/Rat RAGE Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunocytochemistry,Bioassay,Flow Cytometry,Immunoprecipitation,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen.
target :
RAGE/AGER
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
175410
concentration :
LYOPH
conjugate :
Unconjugated
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse RAGE, Gly23-Ala342, Accession # NP_031451
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Hamster,Human,Mouse,Rat,Transgenic Mouse
specificity :
Detects mouse and rat RAGE in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant human RAGE is observed.
gene symbol :
Ager
top caption :
Detection of Mouse RAGE antibody by Western Blot.
accessionNumbers :
NP_031451
applications :
Bioassay,Immunohistochemistry,Immunocytochemistry,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen
USD :
499 USD
alt names :
advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.