Human RAGE/AGER Antibody | R&D Systems MAB11451-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human RAGE/AGER Antibody

catalog :

MAB11451-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

499 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

176902

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 30

Reference
Schwertner K, Gelles K, Leitner J, Steinberger P, Gundacker C, Vrticka R, et al. Human intestine and placenta exhibit tissue-specific expression of RAGE isoforms. Heliyon. 2023;9:e18247 pubmed publisher
Han Z, Andr x161 M, Madhavan B, Kaymak S, Sulaj A, Kender Z, et al. The importance of nuclear RAGE-Mcm2 axis in diabetes or cancer-associated replication stress. Nucleic Acids Res. 2023;51:2298-2318 pubmed publisher
Wiersma V, Hoonhorst S, ten Hacken N, van den Berge M, Slebos D, Pouwels S. The Decrease in Serum sRAGE Levels Upon Smoking is Associated with Activated Neutrophils. Lung. 2022;200:687-690 pubmed publisher
Kadonosono T, Miyamoto K, Sakai S, Matsuo Y, Kitajima S, Wang Q, et al. AGE/RAGE axis regulates reversible transition to quiescent states of ALK-rearranged NSCLC and pancreatic cancer cells in monolayer cultures. Sci Rep. 2022;12:9886 pubmed publisher
Klont F, Horvatovich P, Bowler R, van Rikxoort E, Charbonnier J, Kwiatkowski M, et al. Plasma sRAGE levels strongly associate with centrilobular emphysema assessed by HRCT scans. Respir Res. 2022;23:15 pubmed publisher
Bui H, Keshawarz A, Hwang S, Yao C, Lee G, Recto K, et al. A genomic approach identifies sRAGE as a putatively causal protein for asthma. J Allergy Clin Immunol. 2022;149:1992-1997.e12 pubmed publisher
Zenker H, Teodorowicz M, Wichers H, Hettinga K. No Glycation Required: Interference of Casein in AGE Receptor Binding Tests. Foods. 2021;10: pubmed publisher
Zhong X, Xie F, Chen L, Liu Z, Wang Q. S100A8 and S100A9 promote endothelial cell activation through the RAGE‑mediated mammalian target of rapamycin complex 2 pathway. Mol Med Rep. 2020;22:5293-5303 pubmed publisher
Deng Y, Govers C, Teodorowicz M, Liobyte I, De Simone I, Hettinga K, et al. Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses. PLoS ONE. 2020;15:e0236212 pubmed publisher
Rolfes V, Ribeiro L, Hawwari I, Böttcher L, Rosero N, Maasewerd S, et al. Platelets Fuel the Inflammasome Activation of Innate Immune Cells. Cell Rep. 2020;31:107615 pubmed publisher
Robert J, Button E, Martin E, McAlary L, Gidden Z, Gilmour M, et al. Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E. Mol Neurodegener. 2020;15:23 pubmed publisher
Healey G, Pan Castillo B, Garcia Parra J, Davies J, Roberts S, Jones E, et al. Antibody drug conjugates against the receptor for advanced glycation end products (RAGE), a novel therapeutic target in endometrial cancer. J Immunother Cancer. 2019;7:280 pubmed publisher
Wu J, Deng Z, Sun M, Zhang W, Yang Y, Zeng Z, et al. Polydatin protects against lipopolysaccharide-induced endothelial barrier disruption via SIRT3 activation. Lab Invest. 2019;: pubmed publisher
Zenker H, Ewaz A, Deng Y, Savelkoul H, van Neerven R, de Jong N, et al. Differential Effects of Dry vs. Wet Heating of β-Lactoglobulin on Formation of sRAGE Binding Ligands and sIgE Epitope Recognition. Nutrients. 2019;11: pubmed publisher
Pickering R, Tikellis C, Rosado C, Tsorotes D, Dimitropoulos A, SMITH M, et al. Transactivation of RAGE mediates angiotensin-induced inflammation and atherogenesis. J Clin Invest. 2019;129:406-421 pubmed publisher
Zhou B, Flodby P, Luo J, Castillo D, Liu Y, Yu F, et al. Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest. 2018;128:970-984 pubmed publisher
Robert J, Button E, Stukas S, Boyce G, Gibbs E, Cowan C, et al. High-density lipoproteins suppress A?-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture. Mol Neurodegener. 2017;12:60 pubmed publisher
Chakraborty P, Björk P, K xe4 llberg E, Olsson A, Riva M, M xf6 rgelin M, et al. Vesicular Location and Transport of S100A8 and S100A9 Proteins in Monocytoid Cells. PLoS ONE. 2015;10:e0145217 pubmed publisher
Liu F, Teodorowicz M, van Boekel M, Wichers H, Hettinga K. The decrease in the IgG-binding capacity of intensively dry heated whey proteins is associated with intense Maillard reaction, structural changes of the proteins and formation of RAGE-ligands. Food Funct. 2016;7:239-49 pubmed publisher
Guan S, Sheu M, Wu C, Chiang C, Liu S. ATP synthase subunit-Î² down-regulation aggravates diabetic nephropathy. Sci Rep. 2015;5:14561 pubmed publisher
Park S, Kim J, Park S, Moon M, Lee K, Park K, et al. RAGE mediated intracellular AÎ² uptake contributes to the breakdown of tight junction in retinal pigment epithelium. Oncotarget. 2015;6:35263-73 pubmed publisher
Liu W, Shen T, Chen R, Wu H, Wang Y, Deng J, et al. Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy. J Biol Chem. 2015;290:20499-510 pubmed publisher
Wang Y, Fang C, Gao H, Bilodeau M, Zhang Z, Croce K, et al. Platelet-derived S100 family member myeloid-related protein-14 regulates thrombosis. J Clin Invest. 2014;124:2160-71 pubmed
Wang L, Luo H, Chen X, Jiang Y, Huang Q. Functional characterization of S100A8 and S100A9 in altering monolayer permeability of human umbilical endothelial cells. PLoS ONE. 2014;9:e90472 pubmed publisher
Tuinman P, Cornet A, Kuipers M, Vlaar A, Schultz M, Beishuizen A, et al. Soluble receptor for advanced glycation end products as an indicator of pulmonary vascular injury after cardiac surgery. BMC Pulm Med. 2013;13:76 pubmed publisher
Yamakawa N, Uchida T, Matthay M, Makita K. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2011;300:L516-25 pubmed publisher
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product information

brand :

R&D Systems

master code :

MAB11451

SKU :

MAB11451-100

product name :

Human RAGE/AGER Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human RAGE/AGER Antibody from R&D Systems is a mouse monoclonal antibody to AGER. This antibody reacts with human,mouse,rat. The Human RAGE/AGER Antibody has been validated for the following applications: Bioassay,ELISA Development,Inhibition,Flow Cytometry,Immunoprecipitation,Western Blot,Neutralization,ELISA Detection,Immunohistochemistry-Frozen,Immunocytochemistry,Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair).

target :

RAGE/AGER

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

176902

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Western Blot 2 ug/mL, Blockade of Receptor-ligand Interaction, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human RAGE, Gln24-Ala344, Accession # Q15109

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Rat

specificity :

Detects human RAGE in ELISAs and Western blots. In Western blots, approximately 25% cross-reactivity with recombinant mouse RAGE and recombinant rat RAGE is observed.

gene symbol :

AGER

endotoxin note :

<0.10 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Human RAGE antibody by Western Blot.

accessionNumbers :

Q15109

applications :

Blockade of Receptor-ligand Interaction,ELISA Capture (Matched Antibody Pair),Bioassay,ELISA Development,Inhibition,Flow Cytometry,Immunoprecipitation,Western Blot,Immunohistochemistry-Frozen,Neutralization,Immunocytochemistry,ELISA Detection

USD :

499 USD

alt names :

advanced glycosylation end product-specific receptor, AGER, RAGE isoform delta, RAGE isoform sRAGE-delta, Receptor for advanced glycosylation end products, receptor for advanced glycosylation end-products, SCARJ1

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage