Human Siglec-9 Antibody | R&D Systems MAB1139-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Siglec-9 Antibody

catalog :

MAB1139-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

479 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

191240

reactivity :

human

application :

western blot, ELISA, neutralization, flow cytometry

more info or order :

R&D Systems product webpage

citations: 7

Reference
Bai F, Chen Z, Xu S, Han L, Zeng X, Huang S, et al. Wogonin attenuates neutrophilic inflammation and airway smooth muscle proliferation through inducing caspase-dependent apoptosis and inhibiting MAPK/Akt signaling in allergic airways. Int Immunopharmacol. 2022;113:109410 pubmed publisher
Vijayan M, Lee C, Wong V, Wang X, Bai K, Wu J, et al. Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. J Cell Sci. 2020;133: pubmed publisher
Haas Q, Boligan K, Jandus C, Schneider C, Simillion C, Stanczak M, et al. Siglec-9 Regulates an Effector Memory CD8+ T-cell Subset That Congregates in the Melanoma Tumor Microenvironment. Cancer Immunol Res. 2019;7:707-718 pubmed publisher
Stanczak M, Siddiqui S, Trefny M, Thommen D, Boligan K, von Gunten S, et al. Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells. J Clin Invest. 2018;128:4912-4923 pubmed publisher
Patras K, Coady A, Olson J, Ali S, RamachandraRao S, Kumar S, et al. Tamm-Horsfall glycoprotein engages human Siglec-9 to modulate neutrophil activation in the urinary tract. Immunol Cell Biol. 2017;95:960-965 pubmed publisher
Beziat V, Descours B, Parizot C, Debre P, Vieillard V. NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE. 2010;5:e11966 pubmed publisher
Carlin A, Uchiyama S, Chang Y, Lewis A, Nizet V, Varki A. Molecular mimicry of host sialylated glycans allows a bacterial pathogen to engage neutrophil Siglec-9 and dampen the innate immune response. Blood. 2009;113:3333-6 pubmed publisher

product information

master code :

MAB1139

SKU :

MAB1139-100

product name :

Human Siglec-9 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

description :

The Human Siglec-9 Antibody from R&D Systems is a mouse monoclonal antibody to Siglec-9. This antibody reacts with human. The Human Siglec-9 Antibody has been validated for the following applications: Flow Cytometry,Neutralization,Western Blot,ELISA Capture (Matched Antibody Pair),CyTOF-ready.

target :

Siglec-9

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

191240

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human Siglec-9, Gln18-Gly348 (predicted), Accession # Q9Y336

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human Siglec-9 in direct ELISAs and Western blots. In direct ELISAs, less than 10% cross-reactivity with recombinant mouse Siglec-E is observed and less than 1% cross-reactivity with recombinant human (rh) Siglec-3, rhSiglec-5, rhSiglec-6, rhSiglec-7, rhSiglec-8 or rhSiglec-10 is observed. In Western blots, approximately 100% cross-reactivity with recombinant mouse Siglec-E is observed under non-reduced conditions.

gene symbol :

SIGLEC9

endotoxin note :

<1.0 EU per 1 ╡g of the antibody by the LAL method.

top caption :

Detection of Siglec-9 antibody in Human Blood Granulocytes antibody by Flow Cytometry.

accessionNumbers :

Q9Y336

applications :

Flow Cytometry,Neutralization,Western Blot,ELISA Capture (Matched Antibody Pair),CyTOF-ready

extended description :

Clone 191240 was used by HLDA to establish CD designation

USD :

479 USD

product details :

Clone 191240 was used by HLDA to establish CD designation

alt names :

CD329, CDw329, FOAP-9, OBBP-Like, Protein FOAP-9, sialic acid binding Ig-like lectin 9, sialic acid-binding Ig-like lectin 9, siglec-9, Siglec9

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage