product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ErbB2/Her2 Antibody
catalog :
MAB1129-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
191924
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
more info or order :
R&D Systems product webpage
citations: 15
Reference
Olson D, Taylor J, Willis K, Hensley K, Allred S, Zaval M, et al. HER2-Selective and Reversible Tyrosine Kinase Inhibitor Tucatinib Potentiates the Activity of T-DM1 in Preclinical Models of HER2-positive Breast Cancer. Cancer Res Commun. 2023;3:1927-1939 pubmed publisher
Lyu N, Pedersen B, Shklovskaya E, Rizos H, Molloy M, Wang Y. SERS characterization of colorectal cancer cell surface markers upon anti-EGFR treatment. Exploration (Beijing). 2022;2:20210176 pubmed publisher
Yang Z, Li L, Turkoz A, Chen P, Harari Steinfeld R, Bobbin M, et al. Contextual reprogramming of CAR-T cells for treatment of HER2+ cancers. J Transl Med. 2021;19:459 pubmed publisher
Joh D, Heggestad J, Zhang S, Anderson G, Bhattacharyya J, Wardell S, et al. Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates. NPJ Breast Cancer. 2021;7:85 pubmed publisher
Kuroda M, Halfmann P, Kawaoka Y. HER2-mediated enhancement of Ebola virus entry. PLoS Pathog. 2020;16:e1008900 pubmed publisher
Kulukian A, Lee P, Taylor J, Rosler R, de Vries P, Watson D, et al. Preclinical Activity of HER2-Selective Tyrosine Kinase Inhibitor Tucatinib as a Single Agent or in Combination with Trastuzumab or Docetaxel in Solid Tumor Models. Mol Cancer Ther. 2020;19:976-987 pubmed publisher
Islam S, Uddin M, Noman A, Akter H, Dity N, Basiruzzman M, et al. Antibody-drug conjugate T-DM1 treatment for HER2+ breast cancer induces ROR1 and confers resistance through activation of Hippo transcriptional coactivator YAP1. EBioMedicine. 2019;43:211-224 pubmed publisher
Claas A, Atta L, Gordonov S, Meyer A, Lauffenburger D. Systems Modeling Identifies Divergent Receptor Tyrosine Kinase Reprogramming to MAPK Pathway Inhibition. Cell Mol Bioeng. 2018;11:451-469 pubmed publisher
Klann T, Black J, Chellappan M, Safi A, Song L, Hilton I, et al. CRISPR-Cas9 epigenome editing enables high-throughput screening for functional regulatory elements in the human genome. Nat Biotechnol. 2017;35:561-568 pubmed publisher
Fina E, Necchi A, Bottelli S, Reduzzi C, Pizzamiglio S, Iacona C, et al. Detection of Circulating Tumour Cells in Urothelial Cancers and Clinical Correlations: Comparison of Two Methods. Dis Markers. 2017;2017:3414910 pubmed publisher
Day K, Lorenzatti Hiles G, Kozminsky M, Dawsey S, Paul A, Broses L, et al. HER2 and EGFR Overexpression Support Metastatic Progression of Prostate Cancer to Bone. Cancer Res. 2017;77:74-85 pubmed publisher
Riedl T, van Boxtel E, Bosch M, Parren P, Gerritsen A. High-Throughput Screening for Internalizing Antibodies by Homogeneous Fluorescence Imaging of a pH-Activated Probe. J Biomol Screen. 2016;21:12-23 pubmed publisher
Han J, Sudheendra L, Kim H, Gee S, Hammock B, Kennedy I. Ultrasensitive on-chip immunoassays with a nanoparticle-assembled photonic crystal. ACS Nano. 2012;6:8570-82 pubmed publisher
Theilacker N, Roller E, Barbee K, Franzreb M, Huang X. Multiplexed protein analysis using encoded antibody-conjugated microbeads. J R Soc Interface. 2011;8:1104-13 pubmed publisher
Khan I, Zhao J, Ghosh P, Ziman M, Sweeney C, Kung H, et al. Microbead arrays for the analysis of ErbB receptor tyrosine kinase activation and dimerization in breast cancer cells. Assay Drug Dev Technol. 2010;8:27-36 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB1129
SKU :
MAB1129-100
product name :
Human ErbB2/Her2 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
seo description :
The Human ErbB2/Her2 Antibody from R&D Systems is a mouse monoclonal antibody to ErbB2/Her2. This antibody reacts with human,mouse. The Human ErbB2/Her2 Antibody has been validated for the following applications: Luminex Development,Flow Cytometry,Immunoprecipitation,Western Blot,Immunocytochemistry,Immunohistochemistry,ELISA Capture (Matched Antibody Pair),CyTOF-ready.
target :
ErbB2/Her2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
191924
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 1 ug/mL, Flow Cytometry 0.25 ug/10^6 cells, Immunohistochemistry 8-25 ug/mL, Immunocytochemistry 8-25 ug/mL, CyTOF-ready, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ErbB2/Her2, Thr23-Thr652, Accession # P04626
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
gene symbol :
ERBB2
top caption :
Detection of ErbB2/Her2 antibody in MCF-7 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
P04626
applications :
Immunohistochemistry,ELISA Capture (Matched Antibody Pair),CyTOF-ready,Luminex Development,Flow Cytometry,Immunoprecipitation,Western Blot,Immunocytochemistry
USD :
489 USD
alt names :
CD340, CD340 antigen, c-erb B2/neu protein, EC 2.7.10, EGFR2, HER2, HER-2, HER2EC 2.7.10.1, herstatin, Metastatic lymph node gene 19 protein, MLN 19, MLN19, Neu Oncogene, NEUHER-2/neu, neuroblastoma/glioblastoma derived oncogene homolog, NGL, NGLTKR1, p185erbB2, Proto-oncogene c-ErbB-2, Proto-oncogene Neu, receptor tyrosine-protein kinase erbB-2, TKR1, Tyrosine kinase-type cell surface receptor HER2, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2(neuro/glioblastoma derived oncogene homolog), v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastomaderived oncogene homolog (avian)
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.