Human Dkk-1 Antibody | R&D Systems MAB10962-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human Dkk-1 Antibody

catalog :

MAB10962-100

quantity :

100 ug (also 25 ug, 500 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

141135

reactivity :

human, mouse

application :

ELISA, immunohistochemistry, neutralization

more info or order :

R&D Systems product webpage

citations: 6

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; human; 1:200; loading ...; fig 6a, 7a	Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, et al. The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene. 2021;40:4486-4502 pubmed publisher
	Folestad A, Ã…lund M, Asteberg S, Fowelin J, Aurell Y, GÃ¶thlin J, et al. Role of Wnt/Î²-catenin and RANKL/OPG in bone healing of diabetic Charcot arthropathy patients. Acta Orthop. 2015;86:415-25 pubmed publisher
	Rachner T, Göbel A, Thiele S, Rauner M, Benad Mehner P, Hadji P, et al. Dickkopf-1 is regulated by the mevalonate pathway in breast cancer. Breast Cancer Res. 2014;16:R20 pubmed publisher
	Bajada S, Marshall M, Wright K, Richardson J, Johnson W. Decreased osteogenesis, increased cell senescence and elevated Dickkopf-1 secretion in human fracture non union stromal cells. Bone. 2009;45:726-35 pubmed publisher
	Heider U, Kaiser M, Mieth M, Lamottke B, Rademacher J, Jakob C, et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur J Haematol. 2009;82:31-8 pubmed publisher
	Qiang Y, Chen Y, Stephens O, Brown N, Chen B, Epstein J, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008;112:196-207 pubmed publisher

product information

brand :

R&D Systems

master code :

MAB10962

SKU :

MAB10962-100

product name :

Human Dkk-1 Antibody

unit size :

100 ug (also 25 ug, 500 ug)

seo description :

The Human Dkk-1 Antibody from R&D Systems is a mouse monoclonal antibody to Dkk-1. This antibody reacts with human,mouse. The Human Dkk-1 Antibody has been validated for the following applications: ELISA Development,Neutralization,Immunohistochemistry,ELISA Capture (Matched Antibody Pair).

target :

Dkk-1

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

141135

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Immunohistochemistry 8-25 ug/mL, ELISA Capture (Matched Antibody Pair) 2-8 ug/mL

host :

Mouse

immunogen :

S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Dkk-1, Thr32-His266, Accession # O94907

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Detects human Dkk-1 in ELISAs. In sandwich immunoassays, no cross-reactivity or interference with recombinant human (rh) Dkk-4, rhKremen-1, rhKremen-2 or rhLRP-6 is observed.

gene symbol :

DKK1

top caption :

Dkk-1 antibody in Human Colon by Immunohistochemistry (IHC-P).

accessionNumbers :

O94907

applications :

Immunohistochemistry,ELISA Capture (Matched Antibody Pair),ELISA Development,Neutralization

USD :

489 USD

alt names :

dickkopf (Xenopus laevis) homolog 1, dickkopf homolog 1 (Xenopus laevis), dickkopf related protein-1, Dickkopf-1, dickkopf-related protein 1, Dkk1, DKK-1, hDkk-1, SKdickkopf-1 like

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage