Human NKG2A/CD159a Antibody | R&D Systems MAB1059-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human NKG2A/CD159a Antibody

catalog :

MAB1059-100

quantity :

100 ug (also 500 ug, 25 ug)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

131411

reactivity :

human, mouse

application :

ELISA, neutralization, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
flow cytometry; human; loading ...; fig 4d	Altvater B, Kailayangiri S, Pérez Lanuza L, Urban K, Greune L, Flügge M, et al. HLA-G and HLA-E Immune Checkpoints Are Widely Expressed in Ewing Sarcoma but Have Limited Functional Impact on the Effector Functions of Antigen-Specific CAR T Cells. Cancers (Basel). 2021;13: pubmed publisher
	Wang J, Chai Q, Lei Z, Wang Y, He J, Ge P, et al. LILRB1-HLA-G axis defines a checkpoint driving natural killer cell exhaustion in tuberculosis. EMBO Mol Med. 2024;16:1755-1790 pubmed publisher
	Scopelliti F, Dimartino V, Cattani C, Cavani A. Functional TRPA1 Channels Regulate CD56dimCD16+ NK Cell Cytotoxicity against Tumor Cells. Int J Mol Sci. 2023;24: pubmed publisher
	Jiang L, Fei H, Jin X, Liu X, Yang C, Li C, et al. Extracellular Vesicle-Mediated Secretion of HLA-E by Trophoblasts Maintains Pregnancy by Regulating the Metabolism of Decidual NK Cells. Int J Biol Sci. 2021;17:4377-4395 pubmed publisher
	H xf2 G, Celik A, Huyton T, Hiemisch W, Blasczyk R, Simper G, et al. NKG2A/CD94 Is a New Immune Receptor for HLA-G and Distinguishes Amino Acid Differences in the HLA-G Heavy Chain. Int J Mol Sci. 2020;21: pubmed publisher
	Pump W, Kraemer T, Huyton T, Hò G, Blasczyk R, Bade Doeding C. Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8⁺ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia. Int J Mol Sci. 2019;20: pubmed publisher
	Muller Durovic B, Grählert J, Devine O, Akbar A, Hess C. CD56-negative NK cells with impaired effector function expand in CMV and EBV co-infected healthy donors with age. Aging (Albany NY). 2019;11:724-740 pubmed publisher
	Sun H, Xu J, Huang Q, Huang M, Li K, Qu K, et al. Reduced CD160 Expression Contributes to Impaired NK-cell Function and Poor Clinical Outcomes in Patients with HCC. Cancer Res. 2018;78:6581-6593 pubmed publisher
	Xia Y, Zhang Q, Zhen Q, Zhao Y, Liu N, Li T, et al. Negative regulation of tumor-infiltrating NK cell in clear cell renal cell carcinoma patients through the exosomal pathway. Oncotarget. 2017;8:37783-37795 pubmed publisher
	Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, et al. WNT5A transforms intestinal CD8Î±Î±âº IELs into an unconventional phenotype with pro-inflammatory features. BMC Gastroenterol. 2015;15:173 pubmed publisher
	Wang F, Zhou Y, Fu B, Wu Y, Zhang R, Sun R, et al. Molecular signatures and transcriptional regulatory networks of human immature decidual NK and mature peripheral NK cells. Eur J Immunol. 2014;44:2771-84 pubmed publisher
	Serrano Pertierra E, Cernuda Morollón E, Brdicka T, Hoøejši V, Lopez Larrea C. L-plastin is involved in NKG2D recruitment into lipid rafts and NKG2D-mediated NK cell migration. J Leukoc Biol. 2014;96:437-45 pubmed publisher
	Nachmani D, Zimmermann A, Oiknine Djian E, Weisblum Y, Livneh Y, Khanh Le V, et al. MicroRNA editing facilitates immune elimination of HCMV infected cells. PLoS Pathog. 2014;10:e1003963 pubmed publisher
	Riederer I, Sievert W, Eissner G, Molls M, Multhoff G. Irradiation-induced up-regulation of HLA-E on macrovascular endothelial cells confers protection against killing by activated natural killer cells. PLoS ONE. 2010;5:e15339 pubmed publisher
	Angelini D, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, et al. NKG2A inhibits NKG2C effector functions of ?? T cells: implications in health and disease. J Leukoc Biol. 2011;89:75-84 pubmed publisher
	Dulphy N, Haas P, Busson M, Belhadj S, Peffault De Latour R, Robin M, et al. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J Immunol. 2008;181:2227-37 pubmed
	Coupel S, Moreau A, Hamidou M, Horejsi V, Soulillou J, Charreau B. Expression and release of soluble HLA-E is an immunoregulatory feature of endothelial cell activation. Blood. 2007;109:2806-14 pubmed
	Brando C, Mukhopadhyay S, Kovacs E, Medina R, Patel P, Catina T, et al. Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. J Leukoc Biol. 2005;78:359-71 pubmed

product information

brand :

R&D Systems

master code :

MAB1059

SKU :

MAB1059-100

product name :

Human NKG2A/CD159a Antibody

unit size :

100 ug (also 500 ug, 25 ug)

seo description :

The Human NKG2A/CD159a Antibody from R&D Systems is a mouse monoclonal antibody to NKG2A/CD159a/KLRC1. This antibody reacts with human,mouse. The Human NKG2A/CD159a Antibody has been validated for the following applications: CyTOF-reported,Flow Cytometry,Affinity Chromatography,Immunoprecipitation,Neutralization,Functional Assay,ELISA Capture,CyTOF-ready.

target :

NKG2A/CD159a

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

131411

concentration :

LYOPH

conjugate :

Unconjugated

dilution :

Flow Cytometry 0.25 ug/10^6 cells, CyTOF-ready

host :

Mouse

immunogen :

BaF3 mouse pro-B cell line transfected with human NKG2A and CD94

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse

specificity :

Recognizes the human NKG2A/CD94 heterodimer. It does not recognize the NKG2C/CD94 heterodimer or the CD94 homodimer.

gene symbol :

KLRC1

top caption :

Detection of NKG2A/CD159a antibody in Human PBMCs antibody by Flow Cytometry.

applications :

CyTOF-ready,Affinity Chromatography,Flow Cytometry,Immunoprecipitation,Neutralization,CyTOF-reported,Functional Assay,ELISA Capture

USD :

489 USD

alt names :

CD159 antigen-like family member A, CD159a, CD159a antigen, C-lectin type II protein, killer cell lectin-like receptor subfamily C, member 1, Klrc1, MGC13374, natural killer cell lectin, natural killer group protein 2, NK cell receptor A, NKG2, NKG2-1/B activating NK receptor, NKG2-A, NKG2-A/B type II integral membrane protein, NKG2-A/B-activating NK receptor, NKG2-A/NKG2-B type II integral membrane protein, NKG2AMGC59791, NKG2-B

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage