Human ADAM8 aa 498-653 Antibody | R&D Systems MAB10311 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human ADAM8 aa 498-653 Antibody

catalog :

MAB10311

quantity :

500 ug (also 25 ug)

price :

579 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

143338

reactivity :

human

application :

western blot, immunocytochemistry, immunoprecipitation, flow cytometry

more info or order :

R&D Systems product webpage

citations: 6

Reference
Mineva N, Pianetti S, Das S, Srinivasan S, Billiald N, Sonenshein G. A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer. Pharmaceutics. 2024;16: pubmed publisher
Verel Yilmaz Y, Fern xe1 ndez J, Sch xe4 fer A, Nevermann S, Cook L, Gercke N, et al. Extracellular Vesicle-Based Detection of Pancreatic Cancer. Front Cell Dev Biol. 2021;9:697939 pubmed publisher
Das S, Romagnoli M, Mineva N, Barillé Nion S, Jezequel P, Campone M, et al. miR-720 is a downstream target of an ADAM8-induced ERK signaling cascade that promotes the migratory and invasive phenotype of triple-negative breast cancer cells. Breast Cancer Res. 2016;18:40 pubmed publisher
Romagnoli M, Mineva N, Polmear M, Conrad C, Srinivasan S, Loussouarn D, et al. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Mol Med. 2014;6:278-94 pubmed publisher
Gómez Gaviro M, Domínguez Luis M, Canchado J, Calafat J, Janssen H, Lara Pezzi E, et al. Expression and regulation of the metalloproteinase ADAM-8 during human neutrophil pathophysiological activation and its catalytic activity on L-selectin shedding. J Immunol. 2007;178:8053-63 pubmed
Johansson M, Lye M, Barthel S, Duffy A, Annis D, Mosher D. Eosinophils adhere to vascular cell adhesion molecule-1 via podosomes. Am J Respir Cell Mol Biol. 2004;31:413-22 pubmed

product information

master code :

MAB10311

SKU :

MAB10311

product name :

Human ADAM8 aa 498-653 Antibody

unit size :

500 ug (also 25 ug)

description :

The Human ADAM8 aa 498-653 Antibody from R&D Systems is a mouse monoclonal antibody to ADAM8. This antibody reacts with human. The Human ADAM8 aa 498-653 Antibody has been validated for the following applications: Flow Cytometry,Western Blot,Functional Assay,Immunocytochemistry,Immunoprecipitation,Intracellular Staining by Flow Cytometry,CyTOF-ready.

target :

ADAM8

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

143338

concentration :

LYOPH

conjugate :

Unconjugated

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human ADAM8 ectodomain, Asp158-Ser653, Accession # P78325

isotype :

IgG1

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human ADAM8 in direct ELISAs and Western blots. Detects aa 498-653 of rhADAM8, which corresponds to the cysteine-rich and EGF-like domains. In direct ELISAs, no cross-reactivity with recombinant human (rh) ADAM9, rhADAM10, rhADAM15, rhBACE, or rhTACE is observed.

gene symbol :

ADAM8

top caption :

Detection of Human ADAM8 antibody by Western Blot.

accessionNumbers :

P78325

applications :

Flow Cytometry,Western Blot,Functional Assay,Immunocytochemistry,Immunoprecipitation,Intracellular Staining by Flow Cytometry,CyTOF-ready

USD :

579 USD

alt names :

a disintegrin and metalloproteinase domain 8, ADAM 8, ADAM metallopeptidase domain 8, CD156a, CD156a antigen, CD156human leukocyte differentiation antigen, Cell surface antigen MS2, EC 3.4.24, EC 3.4.24.-, MGC134985, MS2, MS2disintegrin and metalloproteinase domain-containing protein 8

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage