product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ADAM8 aa 158-497 Antibody
catalog :
MAB1031-100
quantity :
100 ug (also 25 ug, 500 ug)
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
143303
reactivity :
human
application :
western blot, immunoprecipitation
more info or order :
R&D Systems product webpage
citations: 3
Reference
Mineva N, Pianetti S, Das S, Srinivasan S, Billiald N, Sonenshein G. A Novel Class of Human ADAM8 Inhibitory Antibodies for Treatment of Triple-Negative Breast Cancer. Pharmaceutics. 2024;16: pubmed publisher
Conrad C, Yildiz D, Cleary S, Margraf A, Cook L, Schlomann U, et al. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022;7: pubmed publisher
Romagnoli M, Mineva N, Polmear M, Conrad C, Srinivasan S, Loussouarn D, et al. ADAM8 expression in invasive breast cancer promotes tumor dissemination and metastasis. EMBO Mol Med. 2014;6:278-94 pubmed publisher
product information
master code :
MAB1031
SKU :
MAB1031-100
product name :
Human ADAM8 aa 158-497 Antibody
unit size :
100 ug (also 25 ug, 500 ug)
description :
The Human ADAM8 aa 158-497 Antibody from R&D Systems is a mouse monoclonal antibody to ADAM8. This antibody reacts with human,n/a. The Human ADAM8 aa 158-497 Antibody has been validated for the following applications: Functional Assay Control,Immunoprecipitation,Western Blot.
target :
ADAM8
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
143303
concentration :
LYOPH
conjugate :
Unconjugated
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human ADAM8 ectodomain, Asp158-Ser653, Accession # P78325
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,N/A
specificity :
Detects human ADAM8 in direct ELISAs and Western blots. In Western blots, less than 5% cross-reactivity with the ectodomains of recombinant human ADAM9, 10, 15, 17, and 19 is observed. Detects an epitope within aa 201-497 of recombinant human ADAM8 which corresponds to the metalloprotease and disintegrin-like domains.
gene symbol :
ADAM8
top caption :
Detection of Human ADAM8 antibody by Western Blot.
accessionNumbers :
P78325
applications :
Functional Assay Control,Immunoprecipitation,Western Blot
USD :
489 USD
alt names :
a disintegrin and metalloproteinase domain 8, ADAM 8, ADAM metallopeptidase domain 8, CD156a, CD156a antigen, CD156human leukocyte differentiation antigen, Cell surface antigen MS2, EC 3.4.24, EC 3.4.24.-, MGC134985, MS2, MS2disintegrin and metalloproteinase domain-containing protein 8
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.