Mouse Cathepsin D Antibody | R&D Systems MAB1029 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Mouse Cathepsin D Antibody

catalog :

MAB1029

quantity :

500 ug (also 25 ug)

price :

569 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

204712

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

more info or order :

R&D Systems product webpage

citations: 15

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:500; loading ...; fig 5d western blot; mouse; 1:1000; loading ...; fig 5f	Glajch K, Moors T, Chen Y, Bechade P, Nam A, Rajsombath M, et al. Wild-type GBA1 increases the α-synuclein tetramer-monomer ratio, reduces lipid-rich aggregates, and attenuates motor and cognitive deficits in mice. Proc Natl Acad Sci U S A. 2021;118: pubmed publisher
	Griffin E, Jucius T, Sim S, Harris B, Heinz S, Ackerman S. RREB1 regulates neuronal proteostasis and the microtubule network. Sci Adv. 2024;10:eadh3929 pubmed publisher
	Skop xe1 l A, K xe9 ki T, T xf3 th P, Cs xf3 ka B, Koscs xf3 B, N xe9 meth Z, et al. Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling. J Biol Chem. 2022;298:101888 pubmed publisher
	Roney J, Li S, Farfel Becker T, Huang N, Sun T, Xie Y, et al. Lipid-mediated motor-adaptor sequestration impairs axonal lysosome delivery leading to autophagic stress and dystrophy in Niemann-Pick type C. Dev Cell. 2021;56:1452-1468.e8 pubmed publisher
	Courtland J, Bradshaw T, Waitt G, Soderblom E, Ho T, Rajab A, et al. Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. elife. 2021;10: pubmed publisher
	Laopanupong T, Prombutara P, Kanjanasirirat P, Benjaskulluecha S, Boonmee A, Palaga T, et al. Lysosome repositioning as an autophagy escape mechanism by Mycobacterium tuberculosis Beijing strain. Sci Rep. 2021;11:4342 pubmed publisher
	Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, et al. Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. Nat Commun. 2020;11:3848 pubmed publisher
	Farfel Becker T, Roney J, Cheng X, Li S, Cuddy S, Sheng Z. Neuronal Soma-Derived Degradative Lysosomes Are Continuously Delivered to Distal Axons to Maintain Local Degradation Capacity. Cell Rep. 2019;28:51-64.e4 pubmed publisher
	Suzuki C, Tanida I, Ohmuraya M, Oliva Trejo J, Kakuta S, Sunabori T, et al. Lack of Cathepsin D in the Renal Proximal Tubular Cells Resulted in Increased Sensitivity against Renal Ischemia/Reperfusion Injury. Int J Mol Sci. 2019;20: pubmed publisher
	Yan J, Porch M, Court Vazquez B, Bennett M, Zukin R. Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice. Proc Natl Acad Sci U S A. 2018;115:E9707-E9716 pubmed publisher
	Cheng X, Xie Y, Zhou B, Huang N, Farfel Becker T, Sheng Z. Characterization of LAMP1-labeled nondegradative lysosomal and endocytic compartments in neurons. J Cell Biol. 2018;217:3127-3139 pubmed publisher
	Cave C, Park S, Rodriguez M, Nakamura M, Hoke A, Pletnikov M, et al. GDE2 is essential for neuronal survival in the postnatal mammalian spinal cord. Mol Neurodegener. 2017;12:8 pubmed publisher
	Khalkhali Ellis Z, Goossens W, Margaryan N, Hendrix M. Cleavage of Histone 3 by Cathepsin D in the involuting mammary gland. PLoS ONE. 2014;9:e103230 pubmed publisher
	Van Zandt K, Sow F, Florence W, Zwilling B, Satoskar A, Schlesinger L, et al. The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome. J Leukoc Biol. 2008;84:689-700 pubmed publisher
	Lubick K, Radke M, Jutila M. Securinine, a GABAA receptor antagonist, enhances macrophage clearance of phase II C. burnetii: comparison with TLR agonists. J Leukoc Biol. 2007;82:1062-9 pubmed

product information

master code :

MAB1029

SKU :

MAB1029

product name :

Mouse Cathepsin D Antibody

unit size :

500 ug (also 25 ug)

description :

The Mouse Cathepsin D Antibody from R&D Systems is a rat monoclonal antibody to Cathepsin D. This antibody reacts with human,mouse,rat. The Mouse Cathepsin D Antibody has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry.

target :

Cathepsin D

category :

Primary Antibodies

buffer :

Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.

clonality :

Monoclonal

clone :

204712

concentration :

LYOPH

conjugate :

Unconjugated

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant mouse Cathepsin D, Ile21-Leu410, Accession # P18242

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human,Mouse,Rat

specificity :

Detects both the pro and active forms of mouse Cathepsin D in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human Cathepsin D or recombinant mouse Cathepsin E is observed.

gene symbol :

CTSD

accessionNumbers :

P18242

applications :

Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry

USD :

569 USD

alt names :

cathepsin D, cathepsin D (lysosomal aspartyl protease), CPSD, CTSD, EC 3.4.23, EC 3.4.23.5, lysosomal aspartyl peptidase, lysosomal aspartyl protease, MGC2311, neuronal 10

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.

more info or order :

R&D Systems product webpage