product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse/Rat Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody
catalog :
MAB1018
quantity :
100 ug (also 25 ug)
price :
499 USD
clonality :
monoclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
269434
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry, flow cytometry, immunohistochemistry - frozen section
more info or order :
R&D Systems product webpage
citations: 21
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1500; loading ...; fig 6d
Abu El Asrar A, Nawaz M, Ahmad A, Siddiquei M, Allegaert E, Gikandi P, et al. CD146/Soluble CD146 Pathway Is a Novel Biomarker of Angiogenesis and Inflammation in Proliferative Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2021;62:32 pubmed publisher
Ohya S, Kito H, Kajikuri J, Yamaguchi Y, Matsui M. Transcriptional Up-Regulation of FBXW7 by KCa1.1 K+ Channel Inhibition through the Nrf2 Signaling Pathway in Human Prostate Cancer LNCaP Cell Spheroid Model. Int J Mol Sci. 2024;25: pubmed publisher
Abu El Asrar A, Nawaz M, Ahmad A, Dillemans L, Siddiquei M, Allegaert E, et al. CD40 Ligand-CD40 Interaction Is an Intermediary between Inflammation and Angiogenesis in Proliferative Diabetic Retinopathy. Int J Mol Sci. 2023;24: pubmed publisher
Liang Z, Zhang Z, Zhang Q, Dong X, Yang X, Zhang J, et al. The proprotein convertase furin regulates the development of thymic epithelial cells to ensure central immune tolerance. iScience. 2022;25:105233 pubmed publisher
x15a witalska M, Filip Psurska B, Milczarek M, Psurski M, Moszy x144 ska A, D x105 browska A, et al. Combined anticancer therapy with imidazoacridinone analogue C-1305 and paclitaxel in human lung and colon cancer xenografts-Modulation of tumour angiogenesis. J Cell Mol Med. 2022;26:3950-3964 pubmed publisher
Abu El Asrar A, Ahmad A, Nawaz M, Siddiquei M, De Zutter A, Vanbrabant L, et al. Tissue Inhibitor of Metalloproteinase-3 Ameliorates Diabetes-Induced Retinal Inflammation. Front Physiol. 2021;12:807747 pubmed publisher
Shang Y, Zhang X, Lu L, Jiang K, Krohn M, Matschos S, et al. Pharmaceutical immunoglobulin G impairs anti-carcinoma activity of oxaliplatin in colon cancer cells. Br J Cancer. 2021;124:1411-1420 pubmed publisher
Abu El Asrar A, Nawaz M, Ahmad A, De Zutter A, Siddiquei M, Blanter M, et al. Evaluation of Proteoforms of the Transmembrane Chemokines CXCL16 and CX3CL1, Their Receptors, and Their Processing Metalloproteinases ADAM10 and ADAM17 in Proliferative Diabetic Retinopathy. Front Immunol. 2020;11:601639 pubmed publisher
Beck O, Paret C, Russo A, Burhenne J, Fresnais M, Steimel K, et al. Safety and Activity of the Combination of Ceritinib and Dasatinib in Osteosarcoma. Cancers (Basel). 2020;12: pubmed publisher
Abu El Asrar A, Ahmad A, Siddiquei M, De Zutter A, Allegaert E, Gikandi P, et al. The Proinflammatory and Proangiogenic Macrophage Migration Inhibitory Factor Is a Potential Regulator in Proliferative Diabetic Retinopathy. Front Immunol. 2019;10:2752 pubmed publisher
Vewinger N, Huprich S, Seidmann L, Russo A, Alt F, Bender H, et al. IGF1R Is a Potential New Therapeutic Target for HGNET-BCOR Brain Tumor Patients. Int J Mol Sci. 2019;20: pubmed publisher
Chang X, Li S, Xue X, Chang F. Propranolol regulates ERK1/2 signaling pathway and promotes chronic wound healing in diabetic rats. Eur Rev Med Pharmacol Sci. 2019;23:4498-4506 pubmed publisher
Shinsuke K, Junya K, Tomonobu U, Yoshiko K, Izumo N, Takahiko S. Chronic irradiation with low-dose-rate 137Cs-? rays inhibits NGF-induced neurite extension of PC12 cells via Ca2+/calmodulin-dependent kinase II activation. J Radiat Res. 2017;:1-7 pubmed publisher
Barrow McGee R, Kishi N, Joffre C, Ménard L, Hervieu A, Bakhouche B, et al. Beta 1-integrin-c-Met cooperation reveals an inside-in survival signalling on autophagy-related endomembranes. Nat Commun. 2016;7:11942 pubmed publisher
Abu El Asrar A, Siddiquei M, Nawaz M, Geboes K, Mohammad G. The proinflammatory cytokine high-mobility group box-1 mediates retinal neuropathy induced by diabetes. Mediators Inflamm. 2014;2014:746415 pubmed publisher
Clayton K, Haaland M, Douglas Vail M, Mujib S, Chew G, Ndhlovu L, et al. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014;192:782-91 pubmed publisher
Shimizu T, Kasamatsu A, Yamamoto A, Koike K, Ishige S, Takatori H, et al. Annexin A10 in human oral cancer: biomarker for tumoral growth via G1/S transition by targeting MAPK signaling pathways. PLoS ONE. 2012;7:e45510 pubmed publisher
Tonge P, Olariu V, Coca D, Kadirkamanathan V, Burrell K, Billings S, et al. Prepatterning in the stem cell compartment. PLoS ONE. 2010;5:e10901 pubmed publisher
Lane A, Tan J, Hawkins C, Heather A, Davies M. The myeloperoxidase-derived oxidant HOSCN inhibits protein tyrosine phosphatases and modulates cell signalling via the mitogen-activated protein kinase (MAPK) pathway in macrophages. Biochem J. 2010;430:161-9 pubmed publisher
Han Y, Wu G, Deng J, Tao J, Guo L, Tian X, et al. Cellular repressor of E1A-stimulated genes inhibits human vascular smooth muscle cell apoptosis via blocking P38/JNK MAP kinase activation. J Mol Cell Cardiol. 2010;48:1225-35 pubmed publisher
Nevo I, Sagi Assif O, Meshel T, Ben Baruch A, Johrer K, Greil R, et al. The involvement of the fractalkine receptor in the transmigration of neuroblastoma cells through bone-marrow endothelial cells. Cancer Lett. 2009;273:127-39 pubmed publisher
product information
brand :
R&D Systems
master code :
MAB1018
SKU :
MAB1018
product name :
Human/Mouse/Rat Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody
unit size :
100 ug (also 25 ug)
seo description :
The Human/Mouse/Rat Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody from R&D Systems is a rabbit monoclonal antibody to ERK1/ERK2. This antibody reacts with human,mouse,rat,xenograft. The Human/Mouse/Rat Phospho-ERK1 (T202/Y204)/ERK2 (T185/Y187) Antibody has been validated for the following applications: Western Blot,Flow Cytometry,Simple Western,Functional Assay,Immunohistochemistry-Frozen,Immunocytochemistry,Intracellular Staining by Flow Cytometry,CyTOF-ready.
target :
ERK1/ERK2
category :
Primary Antibodies
buffer :
Lyophilized from a 0.2 ╡m filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
269434
concentration :
LYOPH
conjugate :
Unconjugated
dilution :
Western Blot 0.5 ug/mL, Simple Western 5 ug/mL, Intracellular Staining by Flow Cytometry 2.5 ug/10^6 cells, Immunocytochemistry 8-25 ug/mL, CyTOF-ready
host :
Rabbit
immunogen :
Phosphopeptide containing ERK1 T202/Y204 site
isotype :
IgG
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Rat,Xenograft
specificity :
Detects human, mouse, and rat ERK1 and ERK2 dually phosphorylated at T202/Y204 or T185/Y187, respectively.
top caption :
Detection of Mouse, Rat, and Human Phospho-ERK1 (T202/Y204) and ERK2 (T185/Y187) antibody by Western Blot.
applications :
Intracellular Staining by Flow Cytometry,CyTOF-ready,Flow Cytometry,Western Blot,Immunohistochemistry-Frozen,Simple Western,Immunocytochemistry,Functional Assay
USD :
499 USD
alt names :
ERK1, ERK-1, ERT1, ERT2, Extracellular signal-regulated kinase 1, extracellular signal-related kinase 1, HS44KDAP, HUMKER1A, Insulin-stimulated MAP2 kinase, MAPK 1, MAPK1, MAPK2, MAPK3, Microtubule-associated protein 2 kinase, mitogen-activated protein kinase 3, p41mapk, p42mapk, p44erk1, p44-ERK1, p44mapk, p44-MAPK, PRKM1, PRKM2, PRKM3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 ░C as supplied. 1 month, 2 to 8 ░C under sterile conditions after reconstitution. 6 months, -20 to -70 ░C under sterile conditions after reconstitution.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.