Mouse IL-2 Quantikine ELISA Kit | R&D Systems M2000-1 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

R&D Systems

product type :

ELISA/assay

product name :

Mouse IL-2 Quantikine ELISA Kit

catalog :

M2000-1

quantity :

1 Kit (1 Plate) (also 1 Pack (50 Plates), 1 Pack (6 Plates))

price :

655 USD

citations: 58

Reference
Maurice D, Costello P, Diring J, Gualdrini F, Frederico B, Treisman R. IL-2 delivery to CD8+ T cells during infection requires MRTF/SRF-dependent gene expression and cytoskeletal dynamics. Nat Commun. 2024;15:7956 pubmed publisher
Mehta N, Rakhra K, Meetze K, Li B, Momin N, Chang J, et al. CLN-617 Retains IL2 and IL12 in Injected Tumors to Drive Robust and Systemic Immune-Mediated Antitumor Activity. Cancer Immunol Res. 2024;12:1022-1038 pubmed publisher
Cheng H, Ji Z, Wang Y, Li S, Tang T, Wang F, et al. Mycobacterium tuberculosis produces D-serine under hypoxia to limit CD8+ T cell-dependent immunity in mice. Nat Microbiol. 2024;9:1856-1872 pubmed publisher
Qiu Z, Khalife J, Lin A, Ethiraj P, Jaafar C, Chiou L, et al. IRF8-mutant B cell lymphoma evades immunity through a CD74-dependent deregulation of antigen processing and presentation in MHC CII complexes. bioRxiv. 2023;: pubmed publisher
You Y, Kim S, Kim C, Kim I, Shin Y, Kim T, et al. Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide. Microorganisms. 2023;11: pubmed publisher
Ni J, Guo T, Zhou Y, Jiang S, Zhang L, Zhu Z. STING signaling activation modulates macrophage polarization via CCL2 in radiation-induced lung injury. J Transl Med. 2023;21:590 pubmed publisher
Drouin M, Saenz J, Gauttier V, Evrard B, Teppaz G, Pengam S, et al. CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy. Sci Adv. 2022;8:eabo7621 pubmed publisher
Dayani L, Dinani M, Aliomrani M, Hashempour H, Varshosaz J, Taheri A. Immunomodulatory effects of cyclotides isolated from Viola odorata in an experimental autoimmune encephalomyelitis animal model of multiple sclerosis. Mult Scler Relat Disord. 2022;64:103958 pubmed publisher
Hathaway Schrader J, Aartun J, Poulides N, Kuhn M, McCormick B, Chew M, et al. Commensal oral microbiota induces osteoimmunomodulatory effects separate from systemic microbiome in mice. JCI Insight. 2022;7: pubmed publisher
Zhang H, Ge S, Ni B, He K, Zhu P, Wu X, et al. Augmenting ATG14 alleviates atherosclerosis and inhibits inflammation via promotion of autophagosome-lysosome fusion in macrophages. Autophagy. 2021;:1-13 pubmed publisher
Wang F, Chau B, West S, Kimberlin C, Cao F, Schwarz F, et al. Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun. 2021;12:1378 pubmed publisher
Charan Raja M, Kar A, Srinivasan S, Chellappan D, Debnath J, Kar Mahapatra S. Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance. Cytokine. 2021;145:155301 pubmed publisher
Focaccetti C, Benvenuto M, Ciuffa S, Fazi S, Scimeca M, Nardi A, et al. Curcumin Enhances the Antitumoral Effect Induced by the Recombinant Vaccinia Neu Vaccine (rV-neuT) in Mice with Transplanted Salivary Gland Carcinoma Cells. Nutrients. 2020;12: pubmed publisher
Wang R, Huang K. CCL11 increases the proportion of CD4+CD25+Foxp3+ Treg cells and the production of IL‑2 and TGF‑β by CD4+ T cells via the STAT5 signaling pathway. Mol Med Rep. 2020;21:2522-2532 pubmed publisher
Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, et al. Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Cancer Gene Ther. 2019;: pubmed publisher
Guo H, Feng C, Zhang W, Luo Z, Zhang H, Zhang T, et al. Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases. Nat Commun. 2019;10:1981 pubmed publisher
Lania B, Morari J, Almeida A, Silva M, Vieira Damiani G, Lins K, et al. Topical essential fatty acid oil on wounds: Local and systemic effects. PLoS ONE. 2019;14:e0210059 pubmed publisher
Song H, Li X, Liu Y, Lu W, Cui Z, Zhou L, et al. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. Int J Mol Med. 2018;42:193-207 pubmed publisher
Jiang Q, He X, Zou Y, Ding Y, Li H, Chen H. Altered gut microbiome promotes proteinuria in mice induced by Adriamycin. AMB Express. 2018;8:31 pubmed publisher
Vetvicka V, Vetvickova J. Glucans and Cancer: Comparison of Commercially Available Î²-glucans - Part IV. Anticancer Res. 2018;38:1327-1333 pubmed
Iseka F, Goetz B, Mushtaq I, An W, Cypher L, Bielecki T, et al. Role of the EHD Family of Endocytic Recycling Regulators for TCR Recycling and T Cell Function. J Immunol. 2018;200:483-499 pubmed publisher
Yang H, Guo H, Li X, Lin J, Zhang W, Zhao J, et al. Viral RNA-Unprimed Rig-I Restrains Stat3 Activation in the Modulation of Regulatory T Cell/Th17 Cell Balance. J Immunol. 2017;199:119-128 pubmed publisher
Whitfield S, Taylor C, Risdall J, Griffiths G, Jones J, Williamson E, et al. Interference of the T Cell and Antigen-Presenting Cell Costimulatory Pathway Using CTLA4-Ig (Abatacept) Prevents Staphylococcal Enterotoxin B Pathology. J Immunol. 2017;198:3989-3998 pubmed publisher
Fujikura D, Ikesue M, Endo T, Chiba S, Higashi H, Uede T. Death receptor 6 contributes to autoimmunity in lupus-prone mice. Nat Commun. 2017;8:13957 pubmed publisher
Mo L, Chen Y, Li W, Guo S, Wang X, An H, et al. Anti-tumor effects of (1?3)-?-d-glucan from Saccharomyces cerevisiae in S180 tumor-bearing mice. Int J Biol Macromol. 2017;95:385-392 pubmed publisher
Sun J, Jiao K, Niu L, Jiao Y, Song Q, Shen L, et al. Intrafibrillar silicified collagen scaffold modulates monocyte to promote cell homing, angiogenesis and bone regeneration. Biomaterials. 2017;113:203-216 pubmed publisher
Bolz M, Kerber S, Zimmer G, Pluschke G. Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease. PLoS Negl Trop Dis. 2015;9:e0004011 pubmed publisher
Shvedova A, Kisin E, Yanamala N, Tkach A, Gutkin D, Star A, et al. MDSC and TGFÎ² Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes. Cancer Res. 2015;75:1615-23 pubmed publisher
Basu R, Whitley S, Bhaumik S, Zindl C, Schoeb T, Benveniste E, et al. IL-1 signaling modulates activation of STAT transcription factors to antagonize retinoic acid signaling and control the TH17 cell-iTreg cell balance. Nat Immunol. 2015;16:286-95 pubmed publisher
Annamanedi M, Kalle A. Celecoxib sensitizes Staphylococcus aureus to antibiotics in macrophages by modulating SIRT1. PLoS ONE. 2014;9:e99285 pubmed publisher
Yamane K, Indalao I, Chida J, Yamamoto Y, Hanawa M, Kido H. Diisopropylamine dichloroacetate, a novel pyruvate dehydrogenase kinase 4 inhibitor, as a potential therapeutic agent for metabolic disorders and multiorgan failure in severe influenza. PLoS ONE. 2014;9:e98032 pubmed publisher
D Souza A, Desai S, Rudner X, Kelly M, Ruan S, Shellito J. Suppression of the macrophage proteasome by ethanol impairs MHC class I antigen processing and presentation. PLoS ONE. 2013;8:e56890 pubmed publisher
Pandiyan P, Yang X, Saravanamuthu S, Zheng L, Ishihara S, O Shea J, et al. The role of IL-15 in activating STAT5 and fine-tuning IL-17A production in CD4 T lymphocytes. J Immunol. 2012;189:4237-46 pubmed publisher
Xue M, Dervish S, Harrison L, Fulcher G, Jackson C. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice. J Biol Chem. 2012;287:16356-64 pubmed publisher
Sun J, Fu F, Gu W, Yan R, Zhang G, Shen Z, et al. Origination of new immunological functions in the costimulatory molecule B7-H3: the role of exon duplication in evolution of the immune system. PLoS ONE. 2011;6:e24751 pubmed publisher
Sang W, Zhou C, Cheng N, Li Z, Zeng L, Xu K. Control of mouse graft-versus-host disease following allogeneic bone marrow transplantation by blocking the CD28/B7 signaling pathway with lentiviral vector-mediated RNA interference. Immunol Lett. 2011;136:194-202 pubmed publisher
Liu J, Ngai N, Stone G, Yue F, Ostrowski M. The adjuvancy of OX40 ligand (CD252) on an HIV-1 canarypox vaccine. Vaccine. 2009;27:5077-84 pubmed publisher
Kim W, Fan Y, Smith R, Patil B, Jayaprakasha G, McMurray D, et al. Dietary curcumin and limonin suppress CD4+ T-cell proliferation and interleukin-2 production in mice. J Nutr. 2009;139:1042-8 pubmed publisher
Sofra V, Mansour S, Liu M, Gao B, Primpidou E, Wang P, et al. Antigen-loaded ER microsomes from APC induce potent immune responses against viral infection. Eur J Immunol. 2009;39:85-95 pubmed publisher
Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, et al. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response. Vaccine. 2008;26:4237-43 pubmed publisher
Besin G, Gaudreau S, Ménard M, Guindi C, Dupuis G, Amrani A. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes. Diabetes. 2008;57:2107-17 pubmed publisher
Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, et al. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur J Immunol. 2008;38:1358-67 pubmed publisher
Lau A, Biester S, Cornall R, Forrester J. Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells. J Immunol. 2008;180:3889-99 pubmed
Tian F, Grimaldo S, Fujita M, Fugita M, Cutts J, Vujanovic N, et al. The endothelial cell-produced antiangiogenic cytokine vascular endothelial growth inhibitor induces dendritic cell maturation. J Immunol. 2007;179:3742-51 pubmed
Gaudreau S, Guindi C, Ménard M, Besin G, Dupuis G, Amrani A. Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J Immunol. 2007;179:3638-47 pubmed
Ke Y, Sun D, Zhang P, Jiang G, Kaplan H, Shao H. Suppression of established experimental autoimmune uveitis by anti-LFA-1alpha Ab. Invest Ophthalmol Vis Sci. 2007;48:2667-75 pubmed
Yamanouchi J, Rainbow D, Serra P, Howlett S, Hunter K, Garner V, et al. Interleukin-2 gene variation impairs regulatory T cell function and causes autoimmunity. Nat Genet. 2007;39:329-37 pubmed
Bullard D, Hu X, Schoeb T, Collins R, Beaudet A, Barnum S. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis. J Immunol. 2007;178:851-7 pubmed
McCubbin M, Hou G, Abrams G, Dick R, Zhang Z, Brewer G. Tetrathiomolybdate is effective in a mouse model of arthritis. J Rheumatol. 2006;33:2501-6 pubmed
Zhang Q, Yang X, Kundu S, Pins M, Javonovic B, Meyer R, et al. Blockade of transforming growth factor-{beta} signaling in tumor-reactive CD8(+) T cells activates the antitumor immune response cycle. Mol Cancer Ther. 2006;5:1733-43 pubmed
Liu Q, Chen T, Chen G, Li N, Wang J, Ma P, et al. Immunosuppressant triptolide inhibits dendritic cell-mediated chemoattraction of neutrophils and T cells through inhibiting Stat3 phosphorylation and NF-kappaB activation. Biochem Biophys Res Commun. 2006;345:1122-30 pubmed
Hermann Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, et al. PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes. Blood. 2006;107:4841-8 pubmed
Yu G, Luo H, Wu Y, Wu J. EphrinB1 is essential in T-cell-T-cell co-operation during T-cell activation. J Biol Chem. 2004;279:55531-9 pubmed
Megid J, Kaneno R, Nozaki C, Brito C, Almeida M. Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp Immunol Microbiol Infect Dis. 2004;27:393-411 pubmed
Muriglan S, Ramirez Montagut T, Alpdogan O, Van Huystee T, Eng J, Hubbard V, et al. GITR activation induces an opposite effect on alloreactive CD4(+) and CD8(+) T cells in graft-versus-host disease. J Exp Med. 2004;200:149-57 pubmed
Kipnis J, Cardon M, Avidan H, Lewitus G, Mordechay S, Rolls A, et al. Dopamine, through the extracellular signal-regulated kinase pathway, downregulates CD4+CD25+ regulatory T-cell activity: implications for neurodegeneration. J Neurosci. 2004;24:6133-43 pubmed
Oka H, Emori Y, Sasaki H, Shiraishi Y, Yoshinaga K, Kurimoto T. Anti-tumor mechanism of Z-100, an immunomodulatory Arabinomannan extracted from Mycobacterium tuberculosis strain Aoyama B, on pulmonary metastases of B16F10 melanoma: restoration of helper T cell responses via suppression of glucocorticoid-genesis. Microbiol Immunol. 2002;46:343-51 pubmed
Hanisch U, Prinz M, Angstwurm K, Häusler K, Kann O, Kettenmann H, et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur J Immunol. 2001;31:2104-15 pubmed

product information

master code :

M2000

SKU :

M2000-1

product name :

Mouse IL-2 Quantikine ELISA Kit

unit size :

1 Kit (1 Plate) (also 1 Pack (50 Plates), 1 Pack (6 Plates))

description :

The Mouse IL-2 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse IL-2 in cell culture supernates (50 ul), serum (50 ul).

target :

IL-2

category :

ELISAs

species :

Mouse

specificity :

Natural and recombinant mouse IL-2

gene symbol :

Il2

kit type :

Solid Phase Sandwich ELISA

assay length :

4.5 hours

elisaSampleTypes :

Cell Culture Supernates (50 uL), Serum (50 uL)

elisaSensitivity :

3 pg/mL

elisaRange :

15.60 - 1000 pg/mL

top caption :

Mouse IL-2 ELISA Standard Curve

applications :

ELISA

USD :

655 USD

product details :

The Quantikine Mouse IL-2 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-2 levels in cell culture supernates and serum. It contains E. coli -expressed recombinant mouse IL-2 and antibodies raised against the recombinant factor. This immunoassay has been shown to quantitate the recombinant mouse IL-2 accurately. Results obtained using natural mouse IL-2 showed dose curves that were parallel to the standard curves obtained using the recombinant Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-2.

alt names :

aldesleukin, IL2, IL-2, IL-2lymphokine, interleukin 2, interleukin-2, involved in regulation of T-cell clonal expansion, Proleukin, T cell growth factor, T-cell growth factor, TCGF

storage :

Store the unopened product at 2 - 8 ░C. Do not use past expiration date.