This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Mouse IL-12 p70 Quantikine ELISA Kit
catalog :
M1270-1
quantity :
1 Kit (1 Plate) (also 1 Pack (50 Plates), 1 Pack (6 Plates))
price :
655 USD
citations: 122
Reference
Gil de G xf3 mez L, Mattei J, Lee J, Grupp S, Reid G, Seif A. CD4+ T Cells Mediate Dendritic Cell Licensing to Promote Multi-Antigen Anti-Leukemic Immune Response. Cancer Med. 2025;14:e70508 pubmed publisher
Albarracin L, Dentice Maidana S, Fukuyama K, Elean M, Arga xf1 araz Aybar J, Suda Y, et al. Orally Administered Lactobacilli Strains Modulate Alveolar Macrophages and Improve Protection Against Respiratory Superinfection. Biomolecules. 2024;14: pubmed publisher
Blanco T, Nakagawa H, Musayeva A, Krauthammer M, Singh R, Narimatsu A, et al. Acquired immunostimulatory phenotype of migratory CD103+ DCs promotes alloimmunity following corneal transplantation. JCI Insight. 2024;9: pubmed publisher
Bova V, Basilotta R, Casili G, Lanza M, Filippone A, Campolo M, et al. The Protective Role of Troxerutin (Trox) in Counteracting Anaplastic Thyroid Carcinoma (ATC) Progression. Biomedicines. 2024;12: pubmed publisher
Roy S, Roy S, Halder S, Jana K, Ukil A. Leishmania exploits host cAMP/EPAC/calcineurin signaling to induce an IL-33-mediated anti-inflammatory environment for the establishment of infection. J Biol Chem. 2024;300:107366 pubmed publisher
Wang Z, Chen Y, Wu H, Wang M, Mao L, Guo X, et al. Intravenous administration of IL-12 encoding self-replicating RNA-lipid nanoparticle complex leads to safe and effective antitumor responses. Sci Rep. 2024;14:7366 pubmed publisher
Vannini A, Parenti F, Forghieri C, Vannini G, Barboni C, Zaghini A, et al. Decrease in Heparan Sulphate Binding in Tropism-Retargeted Oncolytic Herpes Simplex Virus (ReHV) Delays Blood Clearance and Improves Systemic Anticancer Efficacy. Cancers (Basel). 2024;16: pubmed publisher
Zhang Y, Song Y, Wang X, Shi M, Lin Y, Tao D, et al. An NFAT1-C3a-C3aR Positive Feedback Loop in Tumor-Associated Macrophages Promotes a Glioma Stem Cell Malignant Phenotype. Cancer Immunol Res. 2024;12:363-376 pubmed publisher
Wang J, Ling D, Shi L, Li H, Peng M, Wen H, et al. METTL3-mediated m6A methylation regulates ovarian cancer progression by recruiting myeloid-derived suppressor cells. Cell Biosci. 2023;13:202 pubmed publisher
You Y, Kim S, Kim C, Kim I, Shin Y, Kim T, et al. Immune-Stimulating Potential of Lacticaseibacillus rhamnosus LM1019 in RAW 264.7 Cells and Immunosuppressed Mice Induced by Cyclophosphamide. Microorganisms. 2023;11: pubmed publisher
Jin J, Fan Y, Nguyen T, Yu Z, Song C, Lee S, et al. Fallopia japonica Root Extract Ameliorates Ovalbumin-Induced Airway Inflammation in a CARAS Mouse Model by Modulating the IL-33/TSLP/NF-κB Signaling Pathway. Int J Mol Sci. 2023;24: pubmed publisher
Martin N, Crupi M, Taha Z, Poutou J, Whelan J, Vallati S, et al. Engineering Rapalog-Inducible Genetic Switches Based on Split-T7 Polymerase to Regulate Oncolytic Virus-Driven Production of Tumour-Localized IL-12 for Anti-Cancer Immunotherapy. Pharmaceuticals (Basel). 2023;16: pubmed publisher
Smith K, Minns D, McHugh B, Holloway R, O CONNOR R, Williams A, et al. The antimicrobial peptide cathelicidin drives development of experimental autoimmune encephalomyelitis in mice by affecting Th17 differentiation. PLoS Biol. 2022;20:e3001554 pubmed publisher
Pradhan S, Snehlata -, Manna D, Karmakar S, Singh M, Bhattacharya A, et al. Activation of TLR-pathway to induce host Th1 immune response against visceral leishmaniasis: Involvement of galactosylated-flavonoids. Heliyon. 2022;8:e09868 pubmed publisher
Shen C, Lee C, Chou W, Hwang J, Tyan Y, Chuang H. Liposomal β-Sitosterol Suppresses Metastasis of CT26/luc Colon Carcinoma via Inhibition of MMP-9 and Evoke of Immune System. Pharmaceutics. 2022;14: pubmed publisher
Shi C, Wang S, Han J, Xi L, Li M, Li Z, et al. Functional insights into Brucella transcriptional regulator ArsR. Microb Pathog. 2022;168:105557 pubmed publisher
Sugisawa E, Kondo T, Kumagai Y, Kato H, Takayama Y, Isohashi K, et al. Nociceptor-derived Reg3γ prevents endotoxic death by targeting kynurenine pathway in microglia. Cell Rep. 2022;38:110462 pubmed publisher
Li Q, Tan S, Yang L, He W, Chen L, Shen F, et al. Mechanism of chlorogenic acid in alveolar macrophage polarization in Klebsiella pneumoniae-induced pneumonia. J Leukoc Biol. 2022;112:9-21 pubmed publisher
Abusarah J, Khodayarian F, El Hachem N, Salame N, Olivier M, Balood M, et al. Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice. Cell Rep Med. 2021;2:100455 pubmed publisher
Kos Š, Bosnjak M, Jesenko T, Markelc B, Kamensek U, Znidar K, et al. Non-Clinical In Vitro Evaluation of Antibiotic Resistance Gene-Free Plasmids Encoding Human or Murine IL-12 Intended for First-in-Human Clinical Study. Pharmaceutics. 2021;13: pubmed publisher
Zou J, Jing H, Yuan Y, Lei L, Chen Z, Gou Q, et al. Pore-forming alpha-hemolysin efficiently improves the immunogenicity and protective efficacy of protein antigens. PLoS Pathog. 2021;17:e1009752 pubmed publisher
Ahn H, Carrington C, Hu Y, Liu H, Ng C, Nam H, et al. Nanoparticle-mediated tumor cell expression of mIL-12 via systemic gene delivery treats syngeneic models of murine lung cancers. Sci Rep. 2021;11:9733 pubmed publisher
Yuan Y, Ren Y, Dijk M, Geertsema Doornbusch G, Atema Smit J, Busscher H, et al. Phagocytosis and macrophage polarization on bacterially contaminated dental implant materials and effects on tissue integration. Eur Cell Mater. 2021;41:421-430 pubmed publisher
Charan Raja M, Kar A, Srinivasan S, Chellappan D, Debnath J, Kar Mahapatra S. Oral administration of eugenol oleate cures experimental visceral leishmaniasis through cytokines abundance. Cytokine. 2021;145:155301 pubmed publisher
Xiao J, Zhang G, Gao S, Shen J, Feng H, He Z, et al. Combined administration of SHP2 inhibitor SHP099 and the α7nAChR agonist PNU282987 protect mice against DSS‑induced colitis. Mol Med Rep. 2020;22:2235-2244 pubmed publisher
Maruyama K, Kidoya H, Takemura N, Sugisawa E, Takeuchi O, Kondo T, et al. Zinc Finger Protein St18 Protects against Septic Death by Inhibiting VEGF-A from Macrophages. Cell Rep. 2020;32:107906 pubmed publisher
Kawabe T, Yi J, Kawajiri A, Hilligan K, Fang D, Ishii N, et al. Requirements for the differentiation of innate T-bethigh memory-phenotype CD4+ T lymphocytes under steady state. Nat Commun. 2020;11:3366 pubmed publisher
Leylek R, Alcántara Hernández M, Lanzar Z, Lüdtke A, Perez O, Reizis B, et al. Integrated Cross-Species Analysis Identifies a Conserved Transitional Dendritic Cell Population. Cell Rep. 2019;29:3736-3750.e8 pubmed publisher
Balaji Ragunathrao V, Anwar M, Akhter M, Chavez A, Mao D, Natarajan V, et al. Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling. Cell Rep. 2019;29:3472-3487.e4 pubmed publisher
Iida T, Hirayama D, Minami N, Matsuura M, Wagatsuma K, Kawakami K, et al. Down-regulation of RalGTPase-Activating Protein Promotes Colitis-Associated Cancer via NLRP3 Inflammasome Activation. Cell Mol Gastroenterol Hepatol. 2020;9:277-293 pubmed publisher
Esaki S, Goshima F, Ozaki H, Takano G, Hatano Y, Kawakita D, et al. Oncolytic activity of HF10 in head and neck squamous cell carcinomas. Cancer Gene Ther. 2019;: pubmed publisher
Li Z, Lin Y, Zhang S, Zhou L, Yan G, Wang Y, et al. Emodin regulates neutrophil phenotypes to prevent hypercoagulation and lung carcinogenesis. J Transl Med. 2019;17:90 pubmed publisher
Zhang J, Li H, Wu Q, Chen Y, Deng Y, Yang Z, et al. Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol. 2019;22:101116 pubmed publisher
Simonetti S, Seijas A, Natalini A, Vitale S, Runci D, Soriani A, et al. Dendritic cells modulate c-kit expression on the edge between activation and death. Eur J Immunol. 2019;49:534-545 pubmed publisher
Garaulet G, Perez Chacon G, Alarcón H, Alfranca A, Mulero F, Martinez Torrecuadrada J, et al. Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Cancer Gene Ther. 2019;: pubmed publisher
Mohebbi A, Ebrahimzadeh M, Baghban Rahimi S, Saeidi M, Tabarraei A, Mohebbi S, et al. Non-replicating Newcastle Disease Virus as an adjuvant for DNA vaccine enhances antitumor efficacy through the induction of TRAIL and granzyme B expression. Virus Res. 2019;261:72-80 pubmed publisher
Abdi K, Laky K, Padhan K, Petrovas C, Skinner J, Kabat J, et al. Cutting Edge: Quantitative Determination of CD40L Threshold for IL-12 and IL-23 Production from Dendritic Cells. J Immunol. 2018;201:2879-2884 pubmed publisher
Du R, Zhou Y, Xia M, Lu M, Ding J, Hu G. α-Synuclein disrupts the anti-inflammatory role of Drd2 via interfering β-arrestin2-TAB1 interaction in astrocytes. J Neuroinflammation. 2018;15:258 pubmed publisher
Barrett J, Cai H, Miao J, Khare P, Gonzalez P, Dalsing Hernandez J, et al. Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma. Cancer Gene Ther. 2018;25:106-116 pubmed publisher
Song H, Li X, Liu Y, Lu W, Cui Z, Zhou L, et al. Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS. Int J Mol Med. 2018;42:193-207 pubmed publisher
Lania B, Morari J, Souza A, Silva M, de Almeida A, Veira Damiani G, et al. Topical use and systemic action of green and roasted coffee oils and ground oils in a cutaneous incision model in rats (Rattus norvegicus albinus). PLoS ONE. 2017;12:e0188779 pubmed publisher
Lee Y, Wu C, Sun H, Ko J, Lue K. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine. J Microbiol Immunol Infect. 2018;51:598-607 pubmed publisher
Lampreht Tratar U, Loiacono L, Cemazar M, Kamensek U, Fazio V, Sersa G, et al. Gene Electrotransfer of Plasmid-Encoding IL-12 Recruits the M1 Macrophages and Antigen-Presenting Cells Inducing the Eradication of Aggressive B16F10 Murine Melanoma. Mediators Inflamm. 2017;2017:5285890 pubmed publisher
Stier M, Goleniewska K, Cephus J, Newcomb D, Sherrill T, Boyd K, et al. STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. J Immunol. 2017;199:510-519 pubmed publisher
Ishikawa S, Ishikawa T, Tezuka C, Asano K, Sunagawa M, Hisamitsu T. Efficacy of Juzentaihoto for Tumor Immunotherapy in B16 Melanoma Metastasis Model. Evid Based Complement Alternat Med. 2017;2017:6054706 pubmed publisher
Li L, Wang W, Pan H, Ma G, Shi X, Xie H, et al. Microwave ablation combined with OK-432 induces Th1-type response and specific antitumor immunity in a murine model of breast cancer. J Transl Med. 2017;15:23 pubmed publisher
Kamensek U, Tesic N, Sersa G, Kos Š, Cemazar M. Tailor-made fibroblast-specific and antibiotic-free interleukin 12 plasmid for gene electrotransfer-mediated cancer immunotherapy. Plasmid. 2017;89:9-15 pubmed publisher
Yin S, Li M, Rao X, Yao X, Zhong Q, Wang M, et al. Subtilisin-like protease-1 secreted through type IV secretion system contributes to high virulence of Streptococcus suis 2. Sci Rep. 2016;6:27369 pubmed publisher
Gallagher K, Joshi A, Carson W, Schaller M, ALLEN R, Mukerjee S, et al. Epigenetic changes in bone marrow progenitor cells influence the inflammatory phenotype and alter wound healing in type 2 diabetes. Diabetes. 2015;64:1420-30 pubmed publisher
Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A. Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis. J Immunol. 2014;193:2330-9 pubmed publisher
de Oliveira D, Hastreiter A, Mello A, de Oliveira Beltran J, Oliveira Santos E, Borelli P, et al. The effects of protein malnutrition on the TNF-RI and NF-?B expression via the TNF-? signaling pathway. Cytokine. 2014;69:218-25 pubmed publisher
Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, et al. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response. FASEB J. 2014;28:1756-68 pubmed publisher
Kamensek U, Sersa G, Cemazar M. Evaluation of p21 promoter for interleukin 12 radiation induced transcriptional targeting in a mouse tumor model. Mol Cancer. 2013;12:136 pubmed publisher
Maina V, Marrella V, Mantero S, Cassani B, Fontana E, Anselmo A, et al. Hypomorphic mutation in the RAG2 gene affects dendritic cell distribution and migration. J Leukoc Biol. 2013;94:1221-30 pubmed publisher
Toki S, Goleniewska K, Huckabee M, Zhou W, Newcomb D, Fitzgerald G, et al. PGI? signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol. 2013;94:77-88 pubmed publisher
Guo Z, Wen Z, Qin A, Zhou Y, Liao Z, Liu Z, et al. Antisense oligonucleotide treatment enhances the recovery of acute lung injury through IL-10-secreting M2-like macrophage-induced expansion of CD4+ regulatory T cells. J Immunol. 2013;190:4337-48 pubmed publisher
Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N. Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating β-glucan. J Immunol. 2013;190:4116-28 pubmed publisher
Owens B, Beattie L, Moore J, Brown N, Mann J, Dalton J, et al. IL-10-producing Th1 cells and disease progression are regulated by distinct CD11c? cell populations during visceral leishmaniasis. PLoS Pathog. 2012;8:e1002827 pubmed publisher
Calderón J, Maganto Garcia E, Punzon C, Carrión J, Terhorst C, Fresno M. The receptor Slamf1 on the surface of myeloid lineage cells controls susceptibility to infection by Trypanosoma cruzi. PLoS Pathog. 2012;8:e1002799 pubmed publisher
Paul J, Karmakar S, De T. TLR-mediated distinct IFN-?/IL-10 pattern induces protective immunity against murine visceral leishmaniasis. Eur J Immunol. 2012;42:2087-99 pubmed publisher
Noh K, Son K, Jung I, Kang H, Hwang S, Lee W, et al. Protein kinase C ? (PKC?)-extracellular signal-regulated kinase 1/2 (ERK1/2) signaling cascade regulates glycogen synthase kinase-3 (GSK-3) inhibition-mediated interleukin-10 (IL-10) expression in lipopolysaccharide (LPS)-induced endotoxemia. J Biol Chem. 2012;287:14226-33 pubmed publisher
Ghose P, Ali A, Fang R, Forbes D, Ballard B, Ismail N. The interaction between IL-18 and IL-18 receptor limits the magnitude of protective immunity and enhances pathogenic responses following infection with intracellular bacteria. J Immunol. 2011;187:1333-46 pubmed publisher
Yamamoto Y, Otani S, Hirai H, Nagata K, Aritake K, Urade Y, et al. Dual functions of prostaglandin D2 in murine contact hypersensitivity via DP and CRTH2. Am J Pathol. 2011;179:302-14 pubmed publisher
Reim D, Rossmann Bloeck T, Jusek G, Prazeres da Costa O, Holzmann B. Improved host defense against septic peritonitis in mice lacking MyD88 and TRIF is linked to a normal interferon response. J Leukoc Biol. 2011;90:613-20 pubmed publisher
Diao J, Zhao J, Winter E, Cattral M. Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1(+) conventional dendritic cells through IL-6. J Immunol. 2011;186:5058-67 pubmed publisher
Rau C, Hein K, Sättler M, Kretzschmar B, Hillgruber C, McRae B, et al. Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis. Am J Pathol. 2011;178:1770-81 pubmed publisher
Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, et al. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines. J Immunol. 2011;186:4707-15 pubmed publisher
Wang H, Cheng F, Woan K, Sahakian E, Merino O, Rock Klotz J, et al. Histone deacetylase inhibitor LAQ824 augments inflammatory responses in macrophages through transcriptional regulation of IL-10. J Immunol. 2011;186:3986-96 pubmed publisher
Veltman J, Lambers M, van Nimwegen M, Hendriks R, Hoogsteden H, Hegmans J, et al. Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma. Br J Cancer. 2010;103:629-41 pubmed publisher
Filardy A, Pires D, Nunes M, Takiya C, Freire de Lima C, Ribeiro Gomes F, et al. Proinflammatory clearance of apoptotic neutrophils induces an IL-12(low)IL-10(high) regulatory phenotype in macrophages. J Immunol. 2010;185:2044-50 pubmed publisher
Chalaris A, Adam N, Sina C, Rosenstiel P, Lehmann Koch J, Schirmacher P, et al. Critical role of the disintegrin metalloprotease ADAM17 for intestinal inflammation and regeneration in mice. J Exp Med. 2010;207:1617-24 pubmed publisher
Jung I, Noh K, Lee C, Chun S, Jeong S, Park J, et al. Oncostatin M induces dendritic cell maturation and Th1 polarization. Biochem Biophys Res Commun. 2010;394:272-8 pubmed publisher
Alm A, Li K, Yang D, Andersson R, Lu Y, Wang X. Varying susceptibility of pulmonary cytokine production to lipopolysaccharide in mice. Cytokine. 2010;49:256-63 pubmed publisher
Szymczak W, Deepe G. The CCL7-CCL2-CCR2 axis regulates IL-4 production in lungs and fungal immunity. J Immunol. 2009;183:1964-74 pubmed publisher
Thaxton J, Romero R, Sharma S. TLR9 activation coupled to IL-10 deficiency induces adverse pregnancy outcomes. J Immunol. 2009;183:1144-54 pubmed publisher
Zhang X, Gao L, Lei L, Zhong Y, Dube P, Berton M, et al. A MyD88-dependent early IL-17 production protects mice against airway infection with the obligate intracellular pathogen Chlamydia muridarum. J Immunol. 2009;183:1291-300 pubmed publisher
Johnson T, Rao S, Seder R, Chen M, Graham B. TLR9 agonist, but not TLR7/8, functions as an adjuvant to diminish FI-RSV vaccine-enhanced disease, while either agonist used as therapy during primary RSV infection increases disease severity. Vaccine. 2009;27:3045-52 pubmed publisher
Li H, Ciric B, Yang J, Xu H, Fitzgerald D, Elbehi M, et al. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis. J Neuroimmunol. 2009;208:54-60 pubmed publisher
Caruso R, Stolfi C, Sarra M, Rizzo A, Fantini M, Pallone F, et al. Inhibition of monocyte-derived inflammatory cytokines by IL-25 occurs via p38 Map kinase-dependent induction of Socs-3. Blood. 2009;113:3512-9 pubmed publisher
Li Q, Guo Z, Xu X, Xia S, Cao X. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation. Eur J Immunol. 2008;38:2751-61 pubmed publisher
Da Silva C, Hartl D, Liu W, Lee C, Elias J. TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation. J Immunol. 2008;181:4279-86 pubmed
Ishida Y, Hayashi T, Goto T, Kimura A, Akimoto S, Mukaida N, et al. Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis. J Immunol. 2008;181:4208-18 pubmed
Wells J, Cowled C, Farzaneh F, Noble A. Combined triggering of dendritic cell receptors results in synergistic activation and potent cytotoxic immunity. J Immunol. 2008;181:3422-31 pubmed
Moon D, Kim M, Lee H, Choi Y, Park Y, Heo M, et al. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem Biophys Res Commun. 2008;375:275-9 pubmed publisher
Pobezinskaya Y, Kim Y, Choksi S, Morgan M, Li T, Liu C, et al. The function of TRADD in signaling through tumor necrosis factor receptor 1 and TRIF-dependent Toll-like receptors. Nat Immunol. 2008;9:1047-54 pubmed publisher
Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, et al. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis. Eur J Pharmacol. 2008;590:400-8 pubmed publisher
Mabley J, Pacher P, Murthy K, Williams W, Southan G, Salzman A, et al. The novel inosine analogue, INO-2002, protects against diabetes development in multiple low-dose streptozotocin and non-obese diabetic mouse models of type I diabetes. J Endocrinol. 2008;198:581-9 pubmed publisher
Su X, Johansen M, Looney M, Brown E, Matthay M. CD47 deficiency protects mice from lipopolysaccharide-induced acute lung injury and Escherichia coli pneumonia. J Immunol. 2008;180:6947-53 pubmed
Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, et al. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses. Eur J Immunol. 2008;38:1358-67 pubmed publisher
Chen X, Lin X, Zhao J, Shi W, Zhang H, Wang Y, et al. A tumor-selective biotherapy with prolonged impact on established metastases based on cytokine gene-engineered MSCs. Mol Ther. 2008;16:749-56 pubmed publisher
Kelschenbach J, Ninkovic J, Wang J, Krishnan A, Charboneau R, Barke R, et al. Morphine withdrawal inhibits IL-12 induction in a macrophage cell line through a mechanism that involves cAMP. J Immunol. 2008;180:3670-9 pubmed
Nolan A, Weiden M, Kelly A, Hoshino Y, Hoshino S, Mehta N, et al. CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis. Am J Respir Crit Care Med. 2008;177:301-8 pubmed
Pan P, Wang G, Yin B, Ozao J, Ku T, Divino C, et al. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function. Blood. 2008;111:219-28 pubmed
Gaudreau S, Guindi C, Ménard M, Besin G, Dupuis G, Amrani A. Granulocyte-macrophage colony-stimulating factor prevents diabetes development in NOD mice by inducing tolerogenic dendritic cells that sustain the suppressive function of CD4+CD25+ regulatory T cells. J Immunol. 2007;179:3638-47 pubmed
Rothfuchs A, Bafica A, Feng C, Egen J, Williams D, Brown G, et al. Dectin-1 interaction with Mycobacterium tuberculosis leads to enhanced IL-12p40 production by splenic dendritic cells. J Immunol. 2007;179:3463-71 pubmed
Vogl T, Tenbrock K, Ludwig S, Leukert N, Ehrhardt C, van Zoelen M, et al. Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock. Nat Med. 2007;13:1042-9 pubmed
Lin Y, Liang Y, Chiang B. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. J Leukoc Biol. 2007;82:1473-80 pubmed
Molle C, Nguyen M, Flamand V, Renneson J, Trottein F, De Wit D, et al. IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. J Immunol. 2007;178:7607-15 pubmed
Fujita H, Asahina A, Komine M, Tamaki K. The direct action of 1alpha,25(OH)2-vitamin D3 on purified mouse Langerhans cells. Cell Immunol. 2007;245:70-9 pubmed
Yeh C, Kao S, Lin C, Wang S, Liu C, Kao S. The immunomodulation of endotoxin-induced acute lung injury by hesperidin in vivo and in vitro. Life Sci. 2007;80:1821-31 pubmed
Pierce E, Carpenter K, Jakubzick C, Kunkel S, Flaherty K, Martinez F, et al. Therapeutic targeting of CC ligand 21 or CC chemokine receptor 7 abrogates pulmonary fibrosis induced by the adoptive transfer of human pulmonary fibroblasts to immunodeficient mice. Am J Pathol. 2007;170:1152-64 pubmed
Levy B, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, et al. Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol. 2007;178:496-502 pubmed
Wieland C, Kerver M, Florquin S, Nolte M, Borst J, van Lier R, et al. CD27 contributes to the early systemic immune response to Mycobacterium tuberculosis infection but does not affect outcome. Int Immunol. 2006;18:1531-9 pubmed
Andre E, Stoeger T, Takenaka S, Bahnweg M, Ritter B, Karg E, et al. Inhalation of ultrafine carbon particles triggers biphasic pro-inflammatory response in the mouse lung. Eur Respir J. 2006;28:275-85 pubmed
Németh Z, Csóka B, Wilmanski J, Xu D, Lu Q, Ledent C, et al. Adenosine A2A receptor inactivation increases survival in polymicrobial sepsis. J Immunol. 2006;176:5616-26 pubmed
Delale T, Paquin A, Asselin Paturel C, Dalod M, Brizard G, Bates E, et al. MyD88-dependent and -independent murine cytomegalovirus sensing for IFN-alpha release and initiation of immune responses in vivo. J Immunol. 2005;175:6723-32 pubmed
Trabattoni D, Clivio A, Bray D, Bhagat L, Beltrami S, Maffeis G, et al. Immunization with gp120-depleted whole killed HIV immunogen and a second-generation CpG DNA elicits strong HIV-specific responses in mice. Vaccine. 2006;24:1470-7 pubmed
Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, et al. Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines. Anticancer Res. 2005;25:299-303 pubmed
Harry R, Gegg M, Hankey D, Zambarakji H, Pryce G, Baker D, et al. Suppression of autoimmune retinal disease by lovastatin does not require Th2 cytokine induction. J Immunol. 2005;174:2327-2335 pubmed
Weijer S, Florquin S, van der Poll T. Endogenous interleukin-12 improves the early antimicrobial host response to murine Escherichia coli peritonitis. Shock. 2005;23:54-8 pubmed
Murphey E, Herndon D, Sherwood E. Gamma interferon does not enhance clearance of Pseudomonas aeruginosa but does amplify a proinflammatory response in a murine model of postseptic immunosuppression. Infect Immun. 2004;72:6892-901 pubmed
Megid J, Kaneno R, Nozaki C, Brito C, Almeida M. Increased interleukin-10 associated with low IL-6 concentration correlated with greater survival rates in mice infected by rabies virus vaccinated against it and immunomodulated with P. acnes. Comp Immunol Microbiol Infect Dis. 2004;27:393-411 pubmed
Bleier J, Pillarisetty V, Shah A, Dematteo R. Increased and long-term generation of dendritic cells with reduced function from IL-6-deficient bone marrow. J Immunol. 2004;172:7408-16 pubmed
Virag L, Bai P, Bak I, Pacher P, Mabley J, Liaudet L, et al. Effects of poly(ADP-ribose) polymerase inhibition on inflammatory cell migration in a murine model of asthma. Med Sci Monit. 2004;10:BR77-83 pubmed
Gould M, Greene J, Bhoj V, DeVecchio J, Heinzel F. Distinct modulatory effects of LPS and CpG on IL-18-dependent IFN-gamma synthesis. J Immunol. 2004;172:1754-62 pubmed
Harandi A, Eriksson K, Holmgren J. A protective role of locally administered immunostimulatory CpG oligodeoxynucleotide in a mouse model of genital herpes infection. J Virol. 2003;77:953-62 pubmed
Miller G, Pillarisetty V, Shah A, Lahrs S, Xing Z, Dematteo R. Endogenous granulocyte-macrophage colony-stimulating factor overexpression in vivo results in the long-term recruitment of a distinct dendritic cell population with enhanced immunostimulatory function. J Immunol. 2002;169:2875-85 pubmed
Weighardt H, Kaiser Moore S, Vabulas R, Kirschning C, Wagner H, Holzmann B. Cutting edge: myeloid differentiation factor 88 deficiency improves resistance against sepsis caused by polymicrobial infection. J Immunol. 2002;169:2823-7 pubmed
Huaux F, Arras M, Tomasi D, Barbarin V, Delos M, Coutelier J, et al. A profibrotic function of IL-12p40 in experimental pulmonary fibrosis. J Immunol. 2002;169:2653-61 pubmed
Hanisch U, Prinz M, Angstwurm K, Häusler K, Kann O, Kettenmann H, et al. The protein tyrosine kinase inhibitor AG126 prevents the massive microglial cytokine induction by pneumococcal cell walls. Eur J Immunol. 2001;31:2104-15 pubmed
De Bernardis F, Santoni G, Boccanera M, Spreghini E, Adriani D, Morelli L, et al. Local anticandidal immune responses in a rat model of vaginal infection by and protection against Candida albicans. Infect Immun. 2000;68:3297-304 pubmed
Tkaczyk C, Villa I, Peronet R, David B, Chouaib S, Mecheri S. In vitro and in vivo immunostimulatory potential of bone marrow-derived mast cells on B- and T-lymphocyte activation. J Allergy Clin Immunol. 2000;105:134-42 pubmed
product information
master code :
M1270
SKU :
M1270-1
product name :
Mouse IL-12 p70 Quantikine ELISA Kit
unit size :
1 Kit (1 Plate) (also 1 Pack (50 Plates), 1 Pack (6 Plates))
description :
The Mouse IL-12 p70 Quantikine ELISA Kit from R&D Systems is a Solid Phase Sandwich ELISA that quantifies mouse IL-12 p70/IL-12A in cell culture supernates (50 ul), serum (50 ul).
target :
IL-12 p70
category :
ELISAs
species :
Mouse
specificity :
Natural and recombinant mouse IL-12 p70
gene symbol :
Il12a
kit type :
Solid Phase Sandwich ELISA
assay length :
4.5 hours
elisaSampleTypes :
Cell Culture Supernates (50 uL), Serum (50 uL)
elisaSensitivity :
2.5 pg/mL
elisaRange :
7.80 - 500 pg/mL
top caption :
Mouse IL-12 p70 ELISA Linearity
applications :
ELISA
USD :
655 USD
product details :
The Quantikine Mouse IL-12 p70 Immunoassay is a 4.5 hour solid phase ELISA designed to measure mouse IL-12 p70 in cell culture supernates and mouse serum. It contains recombinant mouse IL-12 expressed in Sf 21 insect cells using a baculovirus expression vector and antibodies raised against recombinant mouse IL-12. This immunoassay has been shown to accurately quantitate the recombinant factor. Results obtained using natural mouse IL-12 showed linear curves that were parallel to the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for natural mouse IL-12 p70.
alt names :
CLMF p35, CLMF1, Cytotoxic lymphocyte maturation factor 35 kDa subunit, IL12, IL12 p70, IL-12 subunit p35, IL-12, subunit p35, IL12A, interleukin 12, p35, interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocytematuration factor 1, p35), interleukin-12 alpha chain, interleukin-12 subunit alpha, natural killer cell stimulatory factor 1, 35 kD subunit, NF cell stimulatory factor chain 1, NK cell stimulatory factor chain 1, NKSF1, p35
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.