product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human IL-22 PE-conjugated Antibody
catalog :
IC7821P-100
quantity :
100 Tests (also 25 Tests)
price :
429 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
142928
reactivity :
human, mouse
application :
neutralization, flow cytometry
more info or order :
citations: 37
Reference
Lo Conte M, Cosorich I, Ferrarese R, Antonini Cencicchio M, Nobili A, Palmieri V, et al. Alterations of the intestinal mucus layer correlate with dysbiosis and immune dysregulation in human Type 1 Diabetes. EBioMedicine. 2023;91:104567 pubmed publisher
Dhariwala M, Karthikeyan D, Vasquez K, Farhat S, Weckel A, Taravati K, et al. Developing Human Skin Contains Lymphocytes Demonstrating a Memory Signature. Cell Rep Med. 2020;1:100132 pubmed publisher
Liu J, Shang B, Bai J. IL-22/IL-22R1 promotes proliferation and collagen synthesis of MRC-5 cells via the JAK/STAT3 signaling pathway and regulates airway subepithelial fibrosis. Exp Ther Med. 2020;20:2148-2156 pubmed publisher
de Jonge K, Ebering A, Nassiri S, Maby El Hajjami H, Ouertatani Sakouhi H, Baumgaertner P, et al. Circulating CD56bright NK cells inversely correlate with survival of melanoma patients. Sci Rep. 2019;9:4487 pubmed publisher
Ahn R, Yan D, Chang H, Lee K, Bhattarai S, Huang Z, et al. RNA-seq and flow-cytometry of conventional, scalp, and palmoplantar psoriasis reveal shared and distinct molecular pathways. Sci Rep. 2018;8:11368 pubmed publisher
Gresnigt M, Cunha C, Jaeger M, Gonçalves S, Malireddi R, Ammerdorffer A, et al. Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun. 2018;9:2636 pubmed publisher
Li N, van Unen V, Höllt T, Thompson A, van Bergen J, Pezzotti N, et al. Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine. J Exp Med. 2018;215:1383-1396 pubmed publisher
Chitre A, Kattah M, Rosli Y, Pao M, Deswal M, Deeks S, et al. A20 upregulation during treated HIV disease is associated with intestinal epithelial cell recovery and function. PLoS Pathog. 2018;14:e1006806 pubmed publisher
Scriba T, Penn Nicholson A, Shankar S, Hraha T, Thompson E, Sterling D, et al. Sequential inflammatory processes define human progression from M. tuberculosis infection to tuberculosis disease. PLoS Pathog. 2017;13:e1006687 pubmed publisher
Cosorich I, Dalla Costa G, Sorini C, Ferrarese R, Messina M, Dolpady J, et al. High frequency of intestinal TH17 cells correlates with microbiota alterations and disease activity in multiple sclerosis. Sci Adv. 2017;3:e1700492 pubmed publisher
Cordoro K, Hitraya Low M, Taravati K, Sandoval P, Kim E, Sugarman J, et al. Skin-infiltrating, interleukin-22-producing T cells differentiate pediatric psoriasis from adult psoriasis. J Am Acad Dermatol. 2017;77:417-424 pubmed publisher
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaelsson J, et al. Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers. Eur J Immunol. 2017;47:1280-1294 pubmed publisher
Nada M, Wang H, Workalemahu G, Tanaka Y, Morita C. Enhancing adoptive cancer immunotherapy with Vγ2Vδ2 T cells through pulse zoledronate stimulation. J Immunother Cancer. 2017;5:9 pubmed publisher
Zhong W, Zhao L, Liu T, Jiang Z. IL-22-producing CD4+T cells in the treatment response of rheumatoid arthritis to combination therapy with methotrexate and leflunomide. Sci Rep. 2017;7:41143 pubmed publisher
Suurmond J, Habets K, Dorjée A, Huizinga T, Toes R. Expansion of Th17 Cells by Human Mast Cells Is Driven by Inflammasome-Independent IL-1?. J Immunol. 2016;197:4473-4481 pubmed
Ling Y, Cypowyj S, Aytekin C, Galicchio M, Camcioglu Y, Nepesov S, et al. Inherited IL-17RC deficiency in patients with chronic mucocutaneous candidiasis. J Exp Med. 2015;212:619-31 pubmed publisher
Zhou M, Zou R, Gan H, Liang Z, Li F, Lin T, et al. The effect of aging on the frequency, phenotype and cytokine production of human blood CD4?+?CXCR5?+?T follicular helper cells: comparison of aged and young subjects. Immun Ageing. 2014;11:12 pubmed publisher
Shen H, Wang Y, Chen C, Frencher J, Huang D, Yang E, et al. Th17-related cytokines contribute to recall-like expansion/effector function of HMBPP-specific Vγ2Vδ2 T cells after Mycobacterium tuberculosis infection or vaccination. Eur J Immunol. 2015;45:442-51 pubmed publisher
Longman R, Diehl G, Victorio D, Huh J, Galan C, Miraldi E, et al. CX?CR1? mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22. J Exp Med. 2014;211:1571-83 pubmed publisher
Teunissen M, Munneke J, Bernink J, Spuls P, Res P, te Velde A, et al. Composition of innate lymphoid cell subsets in the human skin: enrichment of NCR(+) ILC3 in lesional skin and blood of psoriasis patients. J Invest Dermatol. 2014;134:2351-2360 pubmed publisher
Guo H, Peng D, Yang X, Wang Y, Xu B, Ni J, et al. A higher frequency of circulating IL-22(+)CD4(+) T cells in Chinese patients with newly diagnosed Hashimoto's thyroiditis. PLoS ONE. 2014;9:e84545 pubmed publisher
Gironi M, Saresella M, Rovaris M, Vaghi M, Nemni R, Clerici M, et al. A novel data mining system points out hidden relationships between immunological markers in multiple sclerosis. Immun Ageing. 2013;10:1 pubmed publisher
Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E, et al. IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol. 2012;10:e1001395 pubmed publisher
Duhen T, Duhen R, Lanzavecchia A, Sallusto F, Campbell D. Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells. Blood. 2012;119:4430-40 pubmed publisher
Miyagaki T, Sugaya M, Suga H, Kamata M, Ohmatsu H, Fujita H, et al. IL-22, but not IL-17, dominant environment in cutaneous T-cell lymphoma. Clin Cancer Res. 2011;17:7529-38 pubmed publisher
Liu L, Okada S, Kong X, Kreins A, Cypowyj S, Abhyankar A, et al. Gain-of-function human STAT1 mutations impair IL-17 immunity and underlie chronic mucocutaneous candidiasis. J Exp Med. 2011;208:1635-48 pubmed publisher
Qiao D, Yang B, Li L, Ma J, Zhang X, Lao S, et al. ESAT-6- and CFP-10-specific Th1, Th22 and Th17 cells in tuberculous pleurisy may contribute to the local immune response against Mycobacterium tuberculosis infection. Scand J Immunol. 2011;73:330-7 pubmed publisher
Liu Y, Yang B, Ma J, Wang H, Huang F, Zhang J, et al. Interleukin-21 induces the differentiation of human Tc22 cells via phosphorylation of signal transducers and activators of transcription. Immunology. 2011;132:540-8 pubmed publisher
Res P, Piskin G, de Boer O, van der Loos C, Teeling P, Bos J, et al. Overrepresentation of IL-17A and IL-22 producing CD8 T cells in lesional skin suggests their involvement in the pathogenesis of psoriasis. PLoS ONE. 2010;5:e14108 pubmed publisher
Ramirez J, Brembilla N, Sorg O, Chicheportiche R, Matthes T, Dayer J, et al. Activation of the aryl hydrocarbon receptor reveals distinct requirements for IL-22 and IL-17 production by human T helper cells. Eur J Immunol. 2010;40:2450-9 pubmed publisher
Kisand K, Bøe Wolff A, Podkrajsek K, Tserel L, Link M, Kisand K, et al. Chronic mucocutaneous candidiasis in APECED or thymoma patients correlates with autoimmunity to Th17-associated cytokines. J Exp Med. 2010;207:299-308 pubmed publisher
Carbone T, Nasorri F, Pennino D, Eyerich K, Foerster S, Cifaldi L, et al. CD56highCD16-CD62L- NK cells accumulate in allergic contact dermatitis and contribute to the expression of allergic responses. J Immunol. 2010;184:1102-10 pubmed publisher
Duhen T, Geiger R, Jarrossay D, Lanzavecchia A, Sallusto F. Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells. Nat Immunol. 2009;10:857-63 pubmed publisher
Hughes T, Becknell B, McClory S, Briercheck E, Freud A, Zhang X, et al. Stage 3 immature human natural killer cells found in secondary lymphoid tissue constitutively and selectively express the TH 17 cytokine interleukin-22. Blood. 2009;113:4008-10 pubmed publisher
Eyerich K, Pennino D, Scarponi C, Foerster S, Nasorri F, Behrendt H, et al. IL-17 in atopic eczema: linking allergen-specific adaptive and microbial-triggered innate immune response. J Allergy Clin Immunol. 2009;123:59-66.e4 pubmed publisher
Nistala K, Moncrieffe H, Newton K, Varsani H, Hunter P, Wedderburn L. Interleukin-17-producing T cells are enriched in the joints of children with arthritis, but have a reciprocal relationship to regulatory T cell numbers. Arthritis Rheum. 2008;58:875-87 pubmed publisher
Acosta Rodriguez E, Napolitani G, Lanzavecchia A, Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol. 2007;8:942-9 pubmed
product information
brand :
R&D Systems
master code :
IC7821P
SKU :
IC7821P-100
product name :
Human IL-22 PE-conjugated Antibody
unit size :
100 Tests (also 25 Tests)
seo description :
The Human IL-22 PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to IL-22. This antibody reacts with human,mouse,primate - macaca fascicularis (crab-eating monkey or cynomolgus macaque). The Human IL-22 PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,Bioassay,Neutralization,Intracellular Staining by Flow Cytometry.
target :
IL-22
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
142928
conjugate :
Phycoerythrin
dilution :
Intracellular Staining by Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
E. coli -derived recombinant human IL-22, Ala34-Ile179, Accession # Q9GZX6
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse,Primate - Macaca fascicularis (Crab-eating Monkey or Cynomolgus Macaque)
specificity :
Detects human IL-22 in direct ELISAs. In direct ELISAs, this antibody shows 100% cross-reactivity with recombinant mouse IL-22 and recombinant rat IL-22 and no cross-reactivity with recombinant human IL-10.
gene symbol :
IL22
top caption :
Detection of IL-22 antibody in Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
Q9GZX6
applications :
Intracellular Staining by Flow Cytometry,Bioassay,Flow Cytometry,Neutralization
USD :
429 USD
alt names :
Cytokine Zcyto18, IL-10-related T-cell-derived inducible factor, IL22, IL-D110, IL-TIF, ILTIFIL-10-related T-cell-derived-inducible factor, IL-TIFMGC79382, interleukin 22, interleukin-22, MGC79384, TIFa, TIFIL-23, zcyto18
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.