This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
other
product name :
proTAME
catalog :
I-440-01M
quantity :
1 mg
price :
290 USD
citations: 18
Reference
Schneider M, Gibson B, Otsuka S, Spicer M, Petrovic M, Blaukopf C, et al. A mitotic chromatin phase transition prevents perforation by microtubules. Nature. 2022;609:183-190 pubmed publisher
Das A, Iwata Otsubo A, Destouni A, Dawicki McKenna J, Boese K, Black B, et al. Epigenetic, genetic and maternal effects enable stable centromere inheritance. Nat Cell Biol. 2022;24:748-756 pubmed publisher
Carvalhal S, Bader I, Rooimans M, Oostra A, Balk J, Feichtinger R, et al. Biallelic BUB1 mutations cause microcephaly, developmental delay, and variable effects on cohesion and chromosome segregation. Sci Adv. 2022;8:eabk0114 pubmed publisher
Tischer T, Yang J, Barford D. The APC/C targets the Cep152-Cep63 complex at the centrosome to regulate mitotic spindle assembly. J Cell Sci. 2022;135: pubmed publisher
Thomas C, Wetherall B, Levasseur M, Harris R, Kerridge S, Higgins J, et al. A prometaphase mechanism of securin destruction is essential for meiotic progression in mouse oocytes. Nat Commun. 2021;12:4322 pubmed publisher
Zhang S, Shen Y, Li H, Bi C, Sun Y, Xiong X, et al. The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance. Cell Rep. 2020;32:108102 pubmed publisher
Guillen R, Beckley J, Chen J, Gould K. CRISPR-mediated gene targeting of CK1δ/ε leads to enhanced understanding of their role in endocytosis via phosphoregulation of GAPVD1. Sci Rep. 2020;10:6797 pubmed publisher
Radonova L, Svobodova T, Skultety M, Mrkva O, Libichova L, Stein P, et al. ProTAME Arrest in Mammalian Oocytes and Embryos Does Not Require Spindle Assembly Checkpoint Activity. Int J Mol Sci. 2019;20: pubmed publisher
Raab M, Sanhaji M, Zhou S, Rodel F, El Balat A, Becker S, et al. Blocking Mitotic Exit of Ovarian Cancer Cells by Pharmaceutical Inhibition of the Anaphase-Promoting Complex Reduces Chromosomal Instability. Neoplasia. 2019;21:363-375 pubmed publisher
Bainor A, Saini S, Calderon A, Casado Polanco R, Giner Ramirez B, Moncada C, et al. The HDAC-Associated Sin3B Protein Represses DREAM Complex Targets and Cooperates with APC/C to Promote Quiescence. Cell Rep. 2018;25:2797-2807.e8 pubmed publisher
Cappell S, Mark K, Garbett D, Pack L, Rape M, Meyer T. EMI1 switches from being a substrate to an inhibitor of APC/CCDH1 to start the cell cycle. Nature. 2018;558:313-317 pubmed publisher
Park Y, Ahn J, Cho M, Lee J. ATP depletion during mitotic arrest induces mitotic slippage and APC/CCdh1-dependent cyclin B1 degradation. Exp Mol Med. 2018;50:46 pubmed publisher
Kucharski T, Minshall P, Moustafa Kamal M, Turnell A, Teodoro J. Reciprocal Regulation between 53BP1 and the Anaphase-Promoting Complex/Cyclosome Is Required for Genomic Stability during Mitotic Stress. Cell Rep. 2017;18:1982-1995 pubmed publisher
Choudhury R, Bonacci T, Arceci A, Lahiri D, Mills C, Kernan J, et al. APC/C and SCF(cyclin F) Constitute a Reciprocal Feedback Circuit Controlling S-Phase Entry. Cell Rep. 2016;16:3359-3372 pubmed publisher
Doménech E, Maestre C, Esteban Martínez L, Partida D, Pascual R, Fernández Miranda G, et al. AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest. Nat Cell Biol. 2015;17:1304-16 pubmed publisher
Boekhout M, Wolthuis R. Nek2A destruction marks APC/C activation at the prophase-to-prometaphase transition by spindle-checkpoint-restricted Cdc20. J Cell Sci. 2015;128:1639-53 pubmed publisher
Drosopoulos K, Tang C, Chao W, Linardopoulos S. APC/C is an essential regulator of centrosome clustering. Nat Commun. 2014;5:3686 pubmed publisher
Song L, Craney A, Rape M. Microtubule-dependent regulation of mitotic protein degradation. Mol Cell. 2014;53:179-92 pubmed publisher
product information
brand :
R&D Systems
master code :
I-440
SKU :
I-440-01M
product name :
proTAME
target :
Ubiquitin Ligase (E3) Inhibitors
category :
Supplemental Reagents
sizes available :
1 mg
species :
Multi-Species
extended description :
Cell-permeable APC/C inhibitor. This is in the process of being discontinued. The new catalog number will be 7734.
USD :
276
USD 2023 :
290 USD
product details :
Cell-permeable APC/C inhibitor. This is in the process of being discontinued. The new catalog number will be 7734.
storage :
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.