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company name :
R&D Systems
product type :
protein
product name :
Caspase-9 Inhibitor Z-LEHD-FMK
catalog :
FMK008
quantity :
1 mg
price :
290 USD
more info or order :
citations: 75
Reference
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Qadir A, Stults A, Murmann A, Peter M. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer. Sci Rep. 2020;10:1310 pubmed publisher
An H, Chung K, Park H, Hong J, Gim J, Choi H, et al. CASP9 (caspase 9) is essential for autophagosome maturation through regulation of mitochondrial homeostasis. Autophagy. 2019;:1-20 pubmed publisher
Islam M, Takano R, Yokochi T, Akter J, Nakamura Y, Nakagawara A, et al. Programmed expression of pro-apoptotic BMCC1 during apoptosis, triggered by DNA damage in neuroblastoma cells. BMC Cancer. 2019;19:542 pubmed publisher
Del Gaudio N, Di Costanzo A, Liu N, Conte L, Migliaccio A, Vermeulen M, et al. BRD9 binds cell type-specific chromatin regions regulating leukemic cell survival via STAT5 inhibition. Cell Death Dis. 2019;10:338 pubmed publisher
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Fujiki K, Inamura H, Sugaya T, Matsuoka M. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms. Cell Death Differ. 2019;: pubmed publisher
Ross J, Dungen K, Bressler K, Fredriksen M, Khandige Sharma D, Balasingam N, et al. Eukaryotic initiation factor 5B (eIF5B) provides a critical cell survival switch to glioblastoma cells via regulation of apoptosis. Cell Death Dis. 2019;10:57 pubmed publisher
Kaminski A, Gupta K, Goldufsky J, Lee H, Gupta V, Shafikhani S. Pseudomonas aeruginosa ExoS Induces Intrinsic Apoptosis in Target Host Cells in a Manner That is Dependent on its GAP Domain Activity. Sci Rep. 2018;8:14047 pubmed publisher
Danish L, Imig D, Allgöwer F, Scheurich P, Pollak N. Bcl-2-mediated control of TRAIL-induced apoptotic response in the non-small lung cancer cell line NCI-H460 is effective at late caspase processing steps. PLoS ONE. 2018;13:e0198203 pubmed publisher
Rijal D, Ariana A, Wight A, Kim K, Alturki N, Aamir Z, et al. Differentiated macrophages acquire a pro-inflammatory and cell death-resistant phenotype due to increasing XIAP and p38-mediated inhibition of RipK1. J Biol Chem. 2018;293:11913-11927 pubmed publisher
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Vaisman C, del Moral Hernández O, Moreno Campuzano S, Arechaga Ocampo E, Bonilla Moreno R, Garcia Aguiar I, et al. C33-A cells transfected with E6*I or E6*II the short forms of HPV-16 E6, displayed opposite effects on cisplatin-induced apoptosis. Virus Res. 2018;247:94-101 pubmed publisher
Kim J, Kim J, Roh J, Park C, Seoh J, Hwang E. Reactive oxygen species-induced parthanatos of immunocytes by human cytomegalovirus-associated substance. Microbiol Immunol. 2018;62:229-242 pubmed publisher
Stammer R, Kleinsimon S, Rolff J, Jäger S, Eggert A, Seifert G, et al. Synergistic Antitumour Properties of viscumTT in Alveolar Rhabdomyosarcoma. J Immunol Res. 2017;2017:4874280 pubmed publisher
Kim H, Hwang K, Park D, Oh S, Jun H, Yoon K, et al. Shikonin-induced necroptosis is enhanced by the inhibition of autophagy in non-small cell lung cancer cells. J Transl Med. 2017;15:123 pubmed publisher
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You B, Han B, Park W. Suberoylanilide hydroxamic acid increases anti-cancer effect of tumor necrosis factor-α through up-regulation of TNF receptor 1 in lung cancer cells. Oncotarget. 2017;8:17726-17737 pubmed publisher
Xuan W, Zhao H, Hankin J, Chen L, Yao S, Ma D. Local anesthetic bupivacaine induced ovarian and prostate cancer apoptotic cell death and underlying mechanisms in vitro. Sci Rep. 2016;6:26277 pubmed publisher
Arizmendi O, Picking W, Picking W. Macrophage Apoptosis Triggered by IpaD from Shigella flexneri. Infect Immun. 2016;84:1857-1865 pubmed publisher
Cheung S, Chuang P, Huang H, Hwang Verslues W, Cho C, Yang W, et al. Stage-specific embryonic antigen-3 (SSEA-3) and β3GalT5 are cancer specific and significant markers for breast cancer stem cells. Proc Natl Acad Sci U S A. 2016;113:960-5 pubmed publisher
Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, et al. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model. PLoS ONE. 2015;10:e0136708 pubmed publisher
Oskarsson M, Singh K, Wang J, Vlodavsky I, Li J, Westermark G. Heparan Sulfate Proteoglycans Are Important for Islet Amyloid Formation and Islet Amyloid Polypeptide-induced Apoptosis. J Biol Chem. 2015;290:15121-32 pubmed publisher
Yang Z, Balic A, Michon F, Juuri E, Thesleff I. Mesenchymal Wnt/β-Catenin Signaling Controls Epithelial Stem Cell Homeostasis in Teeth by Inhibiting the Antiapoptotic Effect of Fgf10. Stem Cells. 2015;33:1670-81 pubmed publisher
Harashima N, Minami T, Uemura H, Harada M. Transfection of poly(I:C) can induce reactive oxygen species-triggered apoptosis and interferon-β-mediated growth arrest in human renal cell carcinoma cells via innate adjuvant receptors and the 2-5A system. Mol Cancer. 2014;13:217 pubmed publisher
Mhaidat N, Bouklihacene M, Thorne R. 5-Fluorouracil-induced apoptosis in colorectal cancer cells is caspase-9-dependent and mediated by activation of protein kinase C-δ. Oncol Lett. 2014;8:699-704 pubmed
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Lin J, Lin S, Chen W, Yen Y, Lai C, Tao M, et al. Dengue viral protease interaction with NF-?B inhibitor ?/? results in endothelial cell apoptosis and hemorrhage development. J Immunol. 2014;193:1258-67 pubmed publisher
Jang J, Kim S, Cho E, Jeong S, Park E, Lee W, et al. TRAIL enhances apoptosis of human hepatocellular carcinoma cells sensitized by hepatitis C virus infection: therapeutic implications. PLoS ONE. 2014;9:e98171 pubmed publisher
Liu B, Meng D, Wei T, Zhang S, Hu Y, Wang M. Apoptosis and pro-inflammatory cytokine response of mast cells induced by influenza A viruses. PLoS ONE. 2014;9:e100109 pubmed publisher
Seo H, Ku J, Choi H, Woo J, Jang B, Shin Y, et al. Induction of caspase-dependent apoptosis by apigenin by inhibiting STAT3 signaling in HER2-overexpressing MDA-MB-453 breast cancer cells. Anticancer Res. 2014;34:2869-82 pubmed
Ham S, Kim K, Kwon T, Bak Y, Lee D, Song Y, et al. Luteolin induces intrinsic apoptosis via inhibition of E6/E7 oncogenes and activation of extrinsic and intrinsic signaling pathways in HPV-18-associated cells. Oncol Rep. 2014;31:2683-91 pubmed publisher
Park W. Anti-apoptotic effect of caspase inhibitors on H?O?-treated HeLa cells through early suppression of its oxidative stress. Oncol Rep. 2014;31:2413-21 pubmed publisher
You B, Park W. Suberoylanilide hydroxamic acid-induced HeLa cell death is closely correlated with oxidative stress and thioredoxin 1 levels. Int J Oncol. 2014;44:1745-55 pubmed publisher
Stölting D, Borrmann M, Koch M, Wiese M, Royer H, Bendas G. How liposomal Cisplatin overcomes chemoresistance in ovarian tumour cells. Anticancer Res. 2014;34:525-30 pubmed
Shin H, You B, Park W. PX-12-induced HeLa cell death is associated with oxidative stress and GSH depletion. Oncol Lett. 2013;6:1804-1810 pubmed
Wang J, Zheng X, Zeng G, Zhou Y, Yuan H. Purified vitexin compound 1 induces apoptosis through activation of FOXO3a in hepatocellular carcinoma. Oncol Rep. 2014;31:488-96 pubmed publisher
You B, Shin H, Park W. PX-12 inhibits the growth of A549 lung cancer cells via G2/M phase arrest and ROS-dependent apoptosis. Int J Oncol. 2014;44:301-8 pubmed publisher
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Han B, You B, Park W. Valproic acid inhibits the growth of HeLa cervical cancer cells via caspase-dependent apoptosis. Oncol Rep. 2013;30:2999-3005 pubmed publisher
Bauer G. HOCl-dependent singlet oxygen and hydroxyl radical generation modulate and induce apoptosis of malignant cells. Anticancer Res. 2013;33:3589-602 pubmed
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Cao Y, Adhikari S, Ang A, Moore P, Bhatia M. Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. Am J Physiol Cell Physiol. 2006;291:C503-10 pubmed
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Attali G, Gancz D, Fishelson Z. Increased sensitivity of early apoptotic cells to complement-mediated lysis. Eur J Immunol. 2004;34:3236-45 pubmed
Chopin V, Slomianny C, Hondermarck H, Le Bourhis X. Synergistic induction of apoptosis in breast cancer cells by cotreatment with butyrate and TNF-alpha, TRAIL, or anti-Fas agonist antibody involves enhancement of death receptors' signaling and requires P21(waf1). Exp Cell Res. 2004;298:560-73 pubmed
Shah N, Asch R, Lysholm A, Lebien T. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Blood. 2004;104:2873-8 pubmed
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Sauerwald T, Oyler G, Betenbaugh M. Study of caspase inhibitors for limiting death in mammalian cell culture. Biotechnol Bioeng. 2003;81:329-40 pubmed
Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, et al. Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem. 2002;277:39760-8 pubmed
product information
master code :
FMK008
SKU :
FMK008
product name :
Caspase-9 Inhibitor Z-LEHD-FMK
unit size :
1 mg
target :
Caspase-9
category :
Peptides
species :
Multi-Species
USD :
290 USD
alt names :
APAF-3APAF3, apoptotic protease activating factor 3, Apoptotic protease Mch-6, Apoptotic protease-activating factor 3, CASP9, CASP-9, caspase 9, apoptosis-related cysteine peptidase, caspase-9, Caspase9, EC 3.4.22.62, ICE-LAP6CASPASE-9c, ICE-like apoptotic protease 6, MCH6apoptosis-related cysteine protease
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.