Caspase-6 Inhibitor Z-VEID-FMK | R&D Systems FMK006 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Caspase-6 Inhibitor Z-VEID-FMK

catalog :

FMK006

quantity :

1 mg

price :

290 USD

more info or order :

R&D Systems product webpage

citations: 19

Reference
Chu H, Hou Y, Yang D, Wen L, Shuai H, Yoon C, et al. Coronaviruses exploit a host cysteine-aspartic protease for replication. Nature. 2022;609:785-792 pubmed publisher
Valionyte E, Yang Y, Griffiths S, Bone A, Barrow E, Sharma V, et al. The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner. Cell Death Differ. 2021;: pubmed publisher
Park G, Nhan H, Tyan S, Kawakatsu Y, Zhang C, Navarro M, et al. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep. 2020;31:107839 pubmed publisher
Kratochvilova A, Veselá B, Ledvina V, Svandová E, Kleparnik K, Dadakova K, et al. Osteogenic impact of pro-apoptotic caspase inhibitors in MC3T3-E1 cells. Sci Rep. 2020;10:7489 pubmed publisher
Qadir A, Stults A, Murmann A, Peter M. The mechanism of how CD95/Fas activates the Type I IFN/STAT1 axis, driving cancer stemness in breast cancer. Sci Rep. 2020;10:1310 pubmed publisher
Gonzalez Juarbe N, Bradley K, Riegler A, Reyes L, Brissac T, Park S, et al. Bacterial Pore-Forming Toxins Promote the Activation of Caspases in Parallel to Necroptosis to Enhance Alarmin Release and Inflammation During Pneumonia. Sci Rep. 2018;8:5846 pubmed publisher
Berta T, Perrin F, Pertin M, Tonello R, Liu Y, Chamessian A, et al. Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. Sci Rep. 2017;7:9367 pubmed publisher
Harhouri K, Navarro C, Depetris D, Mattei M, Nissan X, Cau P, et al. MG132-induced progerin clearance is mediated by autophagy activation and splicing regulation. EMBO Mol Med. 2017;9:1294-1313 pubmed publisher
GonzÃ¡lez Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11:e1005337 pubmed publisher
Berta T, Park C, Xu Z, Xie R, Liu T, Lu N, et al. Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-? secretion. J Clin Invest. 2014;124:1173-86 pubmed publisher
El Khoury V, Pierson S, Szwarcbart E, Brons N, Roland O, Cherrier De Wilde S, et al. Disruption of autophagy by the histone deacetylase inhibitor MGCD0103 and its therapeutic implication in B-cell chronic lymphocytic leukemia. Leukemia. 2014;28:1636-46 pubmed publisher
Magnifico S, Saias L, Deléglise B, Duplus E, Kilinc D, Miquel M, et al. NAD+ acts on mitochondrial SirT3 to prevent axonal caspase activation and axonal degeneration. FASEB J. 2013;27:4712-22 pubmed publisher
Schoenmann Z, Assa Kunik E, Tiomny S, Minis A, Haklai Topper L, Arama E, et al. Axonal degeneration is regulated by the apoptotic machinery or a NAD+-sensitive pathway in insects and mammals. J Neurosci. 2010;30:6375-86 pubmed publisher
Lee S, Chan J, Clement M, Pervaiz S. Functional proteomics of resveratrol-induced colon cancer cell apoptosis: caspase-6-mediated cleavage of lamin A is a major signaling loop. Proteomics. 2006;6:2386-94 pubmed
Conde de la Rosa L, Schoemaker M, Vrenken T, Buist Homan M, Havinga R, Jansen P, et al. Superoxide anions and hydrogen peroxide induce hepatocyte death by different mechanisms: involvement of JNK and ERK MAP kinases. J Hepatol. 2006;44:918-29 pubmed
Attali G, Gancz D, Fishelson Z. Increased sensitivity of early apoptotic cells to complement-mediated lysis. Eur J Immunol. 2004;34:3236-45 pubmed
Shah N, Asch R, Lysholm A, Lebien T. Enhancement of stress-induced apoptosis in B-lineage cells by caspase-9 inhibitor. Blood. 2004;104:2873-8 pubmed
Taimen P, Kallajoki M. NuMA and nuclear lamins behave differently in Fas-mediated apoptosis. J Cell Sci. 2003;116:571-83 pubmed
Furukawa Y, Nishimura N, Furukawa Y, Satoh M, Endo H, Iwase S, et al. Apaf-1 is a mediator of E2F-1-induced apoptosis. J Biol Chem. 2002;277:39760-8 pubmed

product information

master code :

FMK006

SKU :

FMK006

product name :

Caspase-6 Inhibitor Z-VEID-FMK

unit size :

1 mg

target :

Caspase-6

category :

Peptides

species :

Multi-Species

USD :

290 USD

alt names :

Apoptotic protease Mch-2, CASP6, CASP-6, caspase 6, apoptosis-related cysteine peptidase, caspase 6, apoptosis-related cysteine protease, caspase-6, Caspase6, EC 3.4.22, Mch2, MCH2EC 3.4.22.59

storage :

Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.

more info or order :

R&D Systems product webpage