product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Caspase-4 Inhibitor Z-YVAD-FMK
catalog :
FMK005
quantity :
1 mg
price :
290 USD
more info or order :
citations: 27
Reference
Johnson A, Sands J, Trivedi K, Russell R, LaRock D, LaRock C. Constitutive secretion of pro-IL-18 allows keratinocytes to initiate inflammation during bacterial infection. PLoS Pathog. 2023;19:e1011321 pubmed publisher
Kobayashi T, Mitsuhashi A, Hongying P, Shioya M, Kojima K, Nishikimi K, et al. Bexarotene-induced cell death in ovarian cancer cells through Caspase-4-gasdermin E mediated pyroptosis. Sci Rep. 2022;12:11123 pubmed publisher
Zhong Q, Roumeliotis T, Kozik Z, Cepeda Molero M, Fernández L, Shenoy A, et al. Clustering of Tir during enteropathogenic E. coli infection triggers calcium influx-dependent pyroptosis in intestinal epithelial cells. PLoS Biol. 2020;18:e3000986 pubmed publisher
Sun J, LaRock D, Skowronski E, Kimmey J, Olson J, Jiang Z, et al. The Pseudomonas aeruginosa protease LasB directly activates IL-1β. EBioMedicine. 2020;60:102984 pubmed publisher
Park G, Nhan H, Tyan S, Kawakatsu Y, Zhang C, Navarro M, et al. Caspase Activation and Caspase-Mediated Cleavage of APP Is Associated with Amyloid β-Protein-Induced Synapse Loss in Alzheimer's Disease. Cell Rep. 2020;31:107839 pubmed publisher
Baek J, Yun H, Kwon G, Lee J, Kim J, Jo Y, et al. PLOD3 suppression exerts an anti-tumor effect on human lung cancer cells by modulating the PKC-delta signaling pathway. Cell Death Dis. 2019;10:156 pubmed publisher
Tang A, Rahavi S, Fung S, Lu H, Yang H, Lim C, et al. Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production. Cell Death Dis. 2018;9:162 pubmed publisher
Liu J, Mustafa S, Barratt D, Hutchinson M. Corticosterone Preexposure Increases NF-κB Translocation and Sensitizes IL-1β Responses in BV2 Microglia-Like Cells. Front Immunol. 2018;9:3 pubmed publisher
Scott L, Bryant A, Rees A, Down B, Jones R, Thornton C. Production and regulation of interleukin-1 family cytokines at the materno-fetal interface. Cytokine. 2017;99:194-202 pubmed publisher
Nishijima N, Hirai T, Misato K, Aoyama M, Kuroda E, Ishii K, et al. Human Scavenger Receptor A1-Mediated Inflammatory Response to Silica Particle Exposure Is Size Specific. Front Immunol. 2017;8:379 pubmed publisher
Freeman L, Guo H, David C, Brickey W, JHA S, Ting J. NLR members NLRC4 and NLRP3 mediate sterile inflammasome activation in microglia and astrocytes. J Exp Med. 2017;214:1351-1370 pubmed publisher
LaRock C, Todd J, LaRock D, Olson J, O Donoghue A, Robertson A, et al. IL-1β is an innate immune sensor of microbial proteolysis. Sci Immunol. 2016;1: pubmed publisher
Naschberger E, Geißdörfer W, Bogdan C, Tripal P, Kremmer E, Sturzl M, et al. Processing and secretion of guanylate binding protein-1 depend on inflammatory caspase activity. J Cell Mol Med. 2017;21:1954-1966 pubmed publisher
Thurston T, Matthews S, Jennings E, Alix E, Shao F, Shenoy A, et al. Growth inhibition of cytosolic Salmonella by caspase-1 and caspase-11 precedes host cell death. Nat Commun. 2016;7:13292 pubmed publisher
González Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11:e1005337 pubmed publisher
Callaway J, Smith S, Widman D, McKinnon K, Scholle F, Sempowski G, et al. Source and Purity of Dengue-Viral Preparations Impact Requirement for Enhancing Antibody to Induce Elevated IL-1β Secretion: A Primary Human Monocyte Model. PLoS ONE. 2015;10:e0136708 pubmed publisher
Callaway J, Smith S, McKinnon K, de Silva A, Crowe J, Ting J. Spleen Tyrosine Kinase (Syk) Mediates IL-1β Induction by Primary Human Monocytes during Antibody-enhanced Dengue Virus Infection. J Biol Chem. 2015;290:17306-20 pubmed publisher
Whidbey C, Vornhagen J, Gendrin C, Boldenow E, Samson J, Doering K, et al. A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury. EMBO Mol Med. 2015;7:488-505 pubmed publisher
Zwack E, Snyder A, Wynosky Dolfi M, Ruthel G, Philip N, Marketon M, et al. Inflammasome activation in response to the Yersinia type III secretion system requires hyperinjection of translocon proteins YopB and YopD. MBio. 2015;6:e02095-14 pubmed publisher
Yakut E, Jakobs C, Peric A, Michel G, Baal N, Bein G, et al. Extracorporeal photopheresis promotes IL-1β production. J Immunol. 2015;194:2569-77 pubmed publisher
Li Q, Yokoshi M, Okada H, Kawahara Y. The cleavage pattern of TDP-43 determines its rate of clearance and cytotoxicity. Nat Commun. 2015;6:6183 pubmed publisher
Roulstone V, Pedersen M, Kyula J, Mansfield D, Khan A, McEntee G, et al. BRAF- and MEK-Targeted Small Molecule Inhibitors Exert Enhanced Antimelanoma Effects in Combination With Oncolytic Reovirus Through ER Stress. Mol Ther. 2015;23:931-942 pubmed publisher
Teigler J, Kagan J, Barouch D. Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity. J Virol. 2014;88:10354-63 pubmed publisher
McCloy R, Shelley E, Roberts C, Boslem E, Biden T, Nicholson R, et al. Role of endoplasmic reticulum stress induction by the plant toxin, persin, in overcoming resistance to the apoptotic effects of tamoxifen in human breast cancer cells. Br J Cancer. 2013;109:3034-41 pubmed publisher
Wu M, Chen S, Yang A, Lin W, Lin Y, Chen N, et al. CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages. Blood. 2013;121:95-106 pubmed publisher
Attali G, Gancz D, Fishelson Z. Increased sensitivity of early apoptotic cells to complement-mediated lysis. Eur J Immunol. 2004;34:3236-45 pubmed
Edgeworth J, Spencer J, Phalipon A, Griffin G, Sansonetti P. Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells. Eur J Immunol. 2002;32:1464-71 pubmed
product information
master code :
FMK005
SKU :
FMK005
product name :
Caspase-4 Inhibitor Z-YVAD-FMK
unit size :
1 mg
target :
Caspase-4
category :
Peptides
species :
Multi-Species
USD :
290 USD
alt names :
apoptotic cysteine protease Mih1/TX, CASP4, CASP-4, caspase 4, apoptosis-related cysteine peptidase, caspase 4, apoptosis-related cysteine protease, caspase-4, Caspase4, EC 3.4.22, EC 3.4.22.57, ICE(rel)II, ICE(rel)-II, ICEREL-II, ICH2, ICH-2, Mih1/TX, Protease ICH-2, Protease TX, TX
storage :
Store the unopened product at -20 to -70 ░C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.