product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human TACE/ADAM17 Ectodomain PE-conjugated Antibody
catalog :
FAB9301P
quantity :
100 Tests
price :
399 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
111633
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 12
Reference
Hugendieck G, Lettau M, Andreas S, Neumann S, Reinhardt N, Arnold P, et al. Chemotherapy-induced release of ADAM17 bearing EV as a potential resistance mechanism in ovarian cancer. J Extracell Vesicles. 2023;12:e12338 pubmed publisher
Tyrinova T, Leplina O, Mishinov S, Tikhonova M, Dolgova E, Proskurina A, et al. Defective Regulation of Membrane TNFα Expression in Dendritic Cells of Glioblastoma Patients Leads to the Impairment of Cytotoxic Activity against Autologous Tumor Cells. Int J Mol Sci. 2020;21: pubmed publisher
Parackova Z, Vrabcová P, Zentsova I, Kayserova J, Richtrova I, Sojka L, et al. Enhanced STAT3 phosphorylation and PD-L1 expression in myeloid dendritic cells indicate impaired IL-27Ralpha signaling in type 1 diabetes. Sci Rep. 2020;10:493 pubmed publisher
Dreschers S, Platen C, Ludwig A, Gille C, Köstlin N, Orlikowsky T. Metalloproteinases TACE and MMP-9 Differentially Regulate Death Factors on Adult and Neonatal Monocytes After Infection with Escherichia coli. Int J Mol Sci. 2019;20: pubmed publisher
Hedemann N, Rogmans C, Sebens S, Wesch D, Reichert M, Schmidt Arras D, et al. ADAM17 inhibition enhances platinum efficiency in ovarian cancer. Oncotarget. 2018;9:16043-16058 pubmed publisher
Lecuyer H, Virion Z, Barnier J, Matczak S, Bourdoulous S, Bianchini E, et al. An ADAM-10 dependent EPCR shedding links meningococcal interaction with endothelial cells to purpura fulminans. PLoS Pathog. 2018;14:e1006981 pubmed publisher
Sharma N, Trinidad C, Trembath A, Markiewicz M. NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release. J Immunol. 2017;199:2865-2872 pubmed publisher
Chitadze G, Lettau M, Luecke S, Wang T, Janssen O, Furst D, et al. NKG2D- and T-cell receptor-dependent lysis of malignant glioma cell lines by human ?? T cells: Modulation by temozolomide and A disintegrin and metalloproteases 10 and 17 inhibitors. Oncoimmunology. 2016;5:e1093276 pubmed
Moreira Tabaka H, Peluso J, Vonesch J, Hentsch D, Kessler P, Reimund J, et al. Unlike for human monocytes after LPS activation, release of TNF-? by THP-1 cells is produced by a TACE catalytically different from constitutive TACE. PLoS ONE. 2012;7:e34184 pubmed publisher
Wang C, Huang C, Lin H, Huang T, Lee K, Lo Y, et al. Increased activation of fibrocytes in patients with chronic obstructive asthma through an epidermal growth factor receptor-dependent pathway. J Allergy Clin Immunol. 2012;129:1367-76 pubmed publisher
Canault M, Leroyer A, Peiretti F, Leseche G, Tedgui A, Bonardo B, et al. Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am J Pathol. 2007;171:1713-23 pubmed
Canault M, Tellier E, Bonardo B, Mas E, Aumailley M, Juhan Vague I, et al. FHL2 interacts with both ADAM-17 and the cytoskeleton and regulates ADAM-17 localization and activity. J Cell Physiol. 2006;208:363-72 pubmed
product information
master code :
FAB9301P
SKU :
FAB9301P
product name :
Human TACE/ADAM17 Ectodomain PE-conjugated Antibody
unit size :
100 Tests
description :
The Human TACE/ADAM17 Ectodomain PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to TACE/ADAM17. This antibody reacts with human. The Human TACE/ADAM17 Ectodomain PE-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
TACE/ADAM17
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
111633
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
Insect ovarian cell line T. ni -derived recombinant human TACE/ADAM17, Pro18-Asn671, Accession # P78536
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects the ectodomain of human TACE/ADAM17 in direct ELISAs. In direct ELISAs, less than 5% cross-reactivity with the ectodomain of recombinant human ADAM8, 9, 15 and recombinant mouse ADAM10 is observed.
gene symbol :
ADAM17
accessionNumbers :
P78536
applications :
Flow Cytometry
USD :
399 USD
alt names :
ADAM 17, ADAM metallopeptidase domain 17, ADAM metallopeptidase domain 18, ADAM17, ADAM18, CD156b, CD156b antigen, CSVP, disintegrin and metalloproteinase domain-containing protein 17, EC 3.4.24.86, MGC71942, Snake venom-like protease, TACEcSVP, TNF-alpha convertase, TNF-alpha converting enzyme, TNF-alpha-converting enzyme, tumor necrosis factor, alpha, converting enzyme
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.