product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human Mer PE-conjugated Antibody
catalog :
FAB8912P
quantity :
100 Tests
price :
489 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
125518
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 11
Reference
Mytych J, Pan Z, Lopez Davis C, Redinger N, Lawrence C, Ziegler J, et al. Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3. bioRxiv. 2023;: pubmed publisher
Chua B, Ngo J, Situ K, Ramirez C, Nakano H, Morizono K. Protein S and Gas6 induce efferocytosis of HIV-1-infected cells. Virology. 2018;515:176-190 pubmed publisher
Yumoto K, Eber M, Wang J, Cackowski F, Decker A, Lee E, et al. Axl is required for TGF-β2-induced dormancy of prostate cancer cells in the bone marrow. Sci Rep. 2016;6:36520 pubmed publisher
Malawista A, Wang X, Trentalange M, Allore H, Montgomery R. Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny. Macrophage (Houst). 2016;3: pubmed
Dutertre C, Clement M, Morvan M, Schakel K, Castier Y, Alsac J, et al. Deciphering the stromal and hematopoietic cell network of the adventitia from non-aneurysmal and aneurysmal human aorta. PLoS ONE. 2014;9:e89983 pubmed publisher
Zizzo G, Guerrieri J, Dittman L, Merrill J, Cohen P. Circulating levels of soluble MER in lupus reflect M2c activation of monocytes/macrophages, autoantibody specificities and disease activity. Arthritis Res Ther. 2013;15:R212 pubmed
Linger R, Lee Sherick A, DeRyckere D, Cohen R, Jacobsen K, McGranahan A, et al. Mer receptor tyrosine kinase is a therapeutic target in pre-B-cell acute lymphoblastic leukemia. Blood. 2013;122:1599-609 pubmed publisher
Zizzo G, Cohen P. IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids. J Immunol. 2013;190:5237-46 pubmed publisher
Zizzo G, Hilliard B, Monestier M, Cohen P. Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction. J Immunol. 2012;189:3508-20 pubmed
Westenskow P, Moreno S, Krohne T, Kurihara T, Zhu S, Zhang Z, et al. Using flow cytometry to compare the dynamics of photoreceptor outer segment phagocytosis in iPS-derived RPE cells. Invest Ophthalmol Vis Sci. 2012;53:6282-90 pubmed publisher
Graham D, Salzberg D, Kurtzberg J, Sather S, Matsushima G, Keating A, et al. Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. Clin Cancer Res. 2006;12:2662-9 pubmed
product information
master code :
FAB8912P
SKU :
FAB8912P
product name :
Human Mer PE-conjugated Antibody
unit size :
100 Tests
description :
The Human Mer PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to Mer. This antibody reacts with human,porcine. The Human Mer PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,Knockout Validated.
target :
Mer
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
125518
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human Mer, Met1-Ala499, Accession # AAB60430
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Porcine
specificity :
Detects human Mer in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) Axl, rhDtk, or recombinant mouse Mer is observed.
gene symbol :
MERTK
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Mer antibody in HepG2 Human hepatocellular Cell Line antibody by Flow Cytometry.
accessionNumbers :
AAB60430
applications :
Flow Cytometry,Knockout Validated
USD :
489 USD
alt names :
c-Eyk, C-mer, c-mer proto-oncogene tyrosine kinase, EC 2.7.10, EC 2.7.10.1, MER, MER receptor tyrosine kinase, MerTK, MGC133349, Receptor tyrosine kinase MerTK, RP38Proto-oncogene c-Mer, STK kinase, tyrosine-protein kinase Mer
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.