product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human TIGIT APC-conjugated Antibody
catalog :
FAB7898A
quantity :
100 Tests
price :
509 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
741182
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 5
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2
Hutten T, Norde W, Woestenenk R, Wang R, Maas F, Kester M, et al. Increased Coexpression of PD-1, TIGIT, and KLRG-1 on Tumor-Reactive CD8+ T Cells During Relapse after Allogeneic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2018;24:666-677 pubmed publisher
Myers J, Schirm D, Bendzick L, Hopps R, Selleck C, Hinderlie P, et al. Balanced engagement of activating and inhibitory receptors mitigates human NK cell exhaustion. JCI Insight. 2022;7: pubmed publisher
Maas R, Hoogstad van Evert J, Van der Meer J, Mekers V, Rezaeifard S, Korman A, et al. TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer. Oncoimmunology. 2020;9:1843247 pubmed publisher
Downs Canner S, Berkey S, Delgoffe G, Edwards R, Curiel T, Odunsi K, et al. Suppressive IL-17A+Foxp3+ and ex-Th17 IL-17AnegFoxp3+ Treg cells are a source of tumour-associated Treg cells. Nat Commun. 2017;8:14649 pubmed publisher
Yasuma K, Yasunaga J, Takemoto K, Sugata K, Mitobe Y, Takenouchi N, et al. HTLV-1 bZIP Factor Impairs Anti-viral Immunity by Inducing Co-inhibitory Molecule, T Cell Immunoglobulin and ITIM Domain (TIGIT). PLoS Pathog. 2016;12:e1005372 pubmed publisher
product information
master code :
FAB7898A
SKU :
FAB7898A
product name :
Human TIGIT APC-conjugated Antibody
unit size :
100 Tests
description :
The Human TIGIT APC-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to TIGIT. This antibody reacts with human. The Human TIGIT APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
TIGIT
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
741182
conjugate :
Allophycocyanin
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human TIGIT, Met1-Pro141, Accession # Q495A1
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human TIGIT in ELISAs. In direct ELISAs, no cross-reactivity with recombinant mouse TIGIT or recombinant human DNAM-1/CD226 is observed.
gene symbol :
TIGIT
top caption :
Detection of TIGIT antibody in Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
Q495A1
applications :
Flow Cytometry
USD :
509 USD
alt names :
T cell immunoreceptor with Ig and ITIM domains, TIGIT, VSIG9, VSTM3, WUCAM
storage :
Store the unopened product at 2 - 8░ C. Do not use past expiration date. Protect from light.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.