product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse CCR2 PE-conjugated Antibody
catalog :
FAB5538P-025
quantity :
25 Tests (also 100 Tests)
price :
179 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
475301
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, mass cytometry
more info or order :
citations: 68
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:50; loading ...; fig s6f
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Lima L, Ham S, Shin H, Chai E, Lek E, Lobb R, et al. Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nat Commun. 2021;12:3543 pubmed publisher
La Rose A, Bazioti V, Hoogerland J, Svendsen A, Groenen A, van Faassen M, et al. Hepatocyte-specific glucose-6-phosphatase deficiency disturbs platelet aggregation and decreases blood monocytes upon fasting-induced hypoglycemia. Mol Metab. 2021;53:101265 pubmed publisher
Hoeffel G, Debroas G, Roger A, Rossignol R, Gouilly J, Laprie C, et al. Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions. Nature. 2021;594:94-99 pubmed publisher
Lind L, Svensson A, Thörn K, Krzyzowska M, Eriksson K. CD8+ T cells in the central nervous system of mice with herpes simplex infection are highly activated and express high levels of CCR5 and CXCR3. J Neurovirol. 2021;27:145-153 pubmed publisher
Felsenstein M, Blank A, Bungert A, Mueller A, Ghori A, Kremenetskaia I, et al. CCR2 of Tumor Microenvironmental Cells Is a Relevant Modulator of Glioma Biology. Cancers (Basel). 2020;12: pubmed publisher
Zhang J, Muri J, Fitzgerald G, Gorski T, Gianni Barrera R, Masschelein E, et al. Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization. Cell Metab. 2020;31:1136-1153.e7 pubmed publisher
Lian J, Ozga A, Sokol C, Luster A. Targeting Lymph Node Niches Enhances Type 1 Immune Responses to Immunization. Cell Rep. 2020;31:107679 pubmed publisher
Dourcy M, Maquet C, Dams L, Gilliaux G, Javaux J, Desmecht D, et al. A gammaherpesvirus licenses CD8 T cells to protect the host from pneumovirus-induced immunopathologies. Mucosal Immunol. 2020;13:799-813 pubmed publisher
Bosteels C, Neyt K, Vanheerswynghels M, Van Helden M, Sichien D, Debeuf N, et al. Inflammatory Type 2 cDCs Acquire Features of cDC1s and Macrophages to Orchestrate Immunity to Respiratory Virus Infection. Immunity. 2020;52:1039-1056.e9 pubmed publisher
Meilandt W, Ngu H, Gogineni A, Lalehzadeh G, Lee S, Srinivasan K, et al. Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model. J Neurosci. 2020;40:1956-1974 pubmed publisher
Brummer G, Fang W, Smart C, Zinda B, Alissa N, Berkland C, et al. CCR2 signaling in breast carcinoma cells promotes tumor growth and invasion by promoting CCL2 and suppressing CD154 effects on the angiogenic and immune microenvironments. Oncogene. 2020;39:2275-2289 pubmed publisher
Shi L, Wang J, Ding N, Zhang Y, Zhu Y, Dong S, et al. Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nat Commun. 2019;10:5421 pubmed publisher
Liu X, Clemens D, Grunkemeyer J, Price J, O Connell K, Chapman N, et al. Mucin-1 is required for Coxsackie Virus B3-induced inflammation in pancreatitis. Sci Rep. 2019;9:10656 pubmed publisher
Sasaki T, Moro K, Kubota T, Kubota N, Kato T, Ohno H, et al. Innate Lymphoid Cells in the Induction of Obesity. Cell Rep. 2019;28:202-217.e7 pubmed publisher
Miyabe C, Miyabe Y, Bricio Moreno L, Lian J, Rahimi R, Miura N, et al. Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. J Clin Invest. 2019;130:3610-3624 pubmed publisher
Cai G, Pan S, Feng N, Zou H, Gu J, Yuan Y, et al. Zearalenone inhibits T cell chemotaxis by inhibiting cell adhesion and migration related proteins. Ecotoxicol Environ Saf. 2019;175:263-271 pubmed publisher
Li J, Wada S, Weaver L, Biswas C, Behrens E, Arany Z. Myeloid Folliculin balances mTOR activation to maintain innate immunity homeostasis. JCI Insight. 2019;5: pubmed publisher
Widmann C, Gandin C, Petit Paitel A, Lazdunski M, Heurteaux C. The Traditional Chinese Medicine MLC901 inhibits inflammation processes after focal cerebral ischemia. Sci Rep. 2018;8:18062 pubmed publisher
Normand S, Waldschmitt N, Neerincx A, Martinez Torres R, Chauvin C, Couturier Maillard A, et al. Proteasomal degradation of NOD2 by NLRP12 in monocytes promotes bacterial tolerance and colonization by enteropathogens. Nat Commun. 2018;9:5338 pubmed publisher
Breznik J, Naidoo A, Foley K, Schulz C, Lau T, Loukov D, et al. TNF, but not hyperinsulinemia or hyperglycemia, is a key driver of obesity-induced monocytosis revealing that inflammatory monocytes correlate with insulin in obese male mice. Physiol Rep. 2018;6:e13937 pubmed publisher
Dunlap M, HOWARD N, Das S, Scott N, Ahmed M, Prince O, et al. A novel role for C-C motif chemokine receptor 2 during infection with hypervirulent Mycobacterium tuberculosis. Mucosal Immunol. 2018;11:1727-1742 pubmed publisher
Vidal P, Ulndreaj A, Badner A, Hong J, Fehlings M. Methylprednisolone treatment enhances early recovery following surgical decompression for degenerative cervical myelopathy without compromise to the systemic immune system. J Neuroinflammation. 2018;15:222 pubmed publisher
Evrard M, Kwok I, Chong S, Teng K, Becht E, Chen J, et al. Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions. Immunity. 2018;48:364-379.e8 pubmed publisher
Barnette D, Cahill T, Gunadasa Rohling M, Carr C, Freeman M, Riley P. iRhom2-mediated proinflammatory signalling regulates heart repair following myocardial infarction. JCI Insight. 2018;3: pubmed publisher
Han S, Glatman Zaretsky A, Andrade Oliveira V, Collins N, Dzutsev A, Shaik J, et al. White Adipose Tissue Is a Reservoir for Memory T Cells and Promotes Protective Memory Responses to Infection. Immunity. 2017;47:1154-1168.e6 pubmed publisher
Liang H, Deng L, Hou Y, Meng X, Huang X, Rao E, et al. Host STING-dependent MDSC mobilization drives extrinsic radiation resistance. Nat Commun. 2017;8:1736 pubmed publisher
Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, et al. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS ONE. 2017;12:e0185133 pubmed publisher
Khedoe P, de Kleijn S, van Oeveren Rietdijk A, Plomp J, de Boer H, van Pel M, et al. Acute and chronic effects of treatment with mesenchymal stromal cells on LPS-induced pulmonary inflammation, emphysema and atherosclerosis development. PLoS ONE. 2017;12:e0183741 pubmed publisher
Vidal P, Karadimas S, Ulndreaj A, Laliberte A, Tetreault L, Forner S, et al. Delayed decompression exacerbates ischemia-reperfusion injury in cervical compressive myelopathy. JCI Insight. 2017;2: pubmed publisher
Zheng L, Hu Y, Wang Y, Huang X, Xu Y, Shen Y, et al. Recruitment of Neutrophils Mediated by Vγ2 γδ T Cells Deteriorates Liver Fibrosis Induced by Schistosoma japonicum Infection in C57BL/6 Mice. Infect Immun. 2017;85: pubmed publisher
Liu B, Zhang H, Zhu Y, Jiang Y, Luo G, Tang F, et al. Cardiac resident macrophages are involved in hypoxia‑induced postnatal cardiomyocyte proliferation. Mol Med Rep. 2017;15:3541-3548 pubmed publisher
Nakano H, Lyons Cohen M, Whitehead G, Nakano K, Cook D. Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung. J Leukoc Biol. 2017;101:1143-1153 pubmed publisher
Lavender N, Yang J, Chen S, Sai J, Johnson C, Owens P, et al. The Yin/Yan of CCL2: a minor role in neutrophil anti-tumor activity in vitro but a major role on the outgrowth of metastatic breast cancer lesions in the lung in vivo. BMC Cancer. 2017;17:88 pubmed publisher
Zhou Q, Zhang Y, Zhao M, Wang X, Ma C, Jiang X, et al. Mature dendritic cell derived from cryopreserved immature dendritic cell shows impaired homing ability and reduced anti-viral therapeutic effects. Sci Rep. 2016;6:39071 pubmed publisher
Reyes J, Lopes F, Leung G, Mancini N, Matisz C, Wang A, et al. Treatment with Cestode Parasite Antigens Results in Recruitment of CCR2+ Myeloid Cells, the Adoptive Transfer of Which Ameliorates Colitis. Infect Immun. 2016;84:3471-3483 pubmed
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Fan Y, Xiong X, Zhang Y, Yan D, Jian Z, Xu B, et al. MKEY, a Peptide Inhibitor of CXCL4-CCL5 Heterodimer Formation, Protects Against Stroke in Mice. J Am Heart Assoc. 2016;5: pubmed publisher
Shiraishi M, Shintani Y, Shintani Y, Ishida H, Saba R, Yamaguchi A, et al. Alternatively activated macrophages determine repair of the infarcted adult murine heart. J Clin Invest. 2016;126:2151-66 pubmed publisher
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product information
brand :
R&D Systems
master code :
FAB5538P
SKU :
FAB5538P-025
product name :
Mouse CCR2 PE-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Mouse CCR2 PE-conjugated Antibody from R&D Systems is a rat monoclonal antibody to CCR2. This antibody reacts with mouse,transgenic mouse. The Mouse CCR2 PE-conjugated Antibody has been validated for the following applications: Mass Cytometry,Flow Cytometry,Immunohistochemistry,Immunocytochemistry.
target :
CCR2
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
475301
conjugate :
Phycoerythrin
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Rat
immunogen :
L1.2 mouse pro-B cell line transfected with mouse CCR2
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse,Transgenic Mouse
specificity :
Detects mouse CCR2 transfectants but not the parental cell line in flow cytometry. Does not detect HEK293 human embryonic kidney cell line transfected with mouse CCR5 in flow cytometry.
gene symbol :
CCR2
top caption :
Detection of CCR2 antibody in Mouse Splenocytes antibody by Flow Cytometry.
applications :
Mass Cytometry,Flow Cytometry,Immunohistochemistry,Immunocytochemistry
USD :
179 USD
alt names :
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2, CC-CKR-2CKR2B, CCR2, CCR-2, CCR2A, CCR2B, CD192, CD192 antigen, chemokine (C-C motif) receptor 2, CKR2, CKR2A, CMKBR2, CMKBR2MGC111760, FLJ78302, MCP-1 receptor, MCP-1-R, MCP-1-RMGC103828, MGC168006, Monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.