product summary
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company name :
R&D Systems
product type :
antibody
product name :
Mouse gp130 APC-conjugated Antibody
catalog :
FAB4681A-100UG
quantity :
100 ug (also 25 ug)
price :
449 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
125623
reactivity :
human, mouse
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 6
Reference
Gupta D, Orehek S, Turunen J, O Donovan L, Gait M, El Andaloussi S, et al. Modulation of Pro-Inflammatory IL-6 Trans-Signaling Axis by Splice Switching Oligonucleotides as a Therapeutic Modality in Inflammation. Cells. 2023;12: pubmed publisher
Nagashima H, Okuyama Y, Hayashi T, Ishii N, So T. TNFR-Associated Factors 2 and 5 Differentially Regulate the Instructive IL-6 Receptor Signaling Required for Th17 Development. J Immunol. 2016;196:4082-9 pubmed publisher
Pratama A, Srivastava M, Williams N, Papa I, Lee S, Dinh X, et al. MicroRNA-146a regulates ICOS-ICOSL signalling to limit accumulation of T follicular helper cells and germinal centres. Nat Commun. 2015;6:6436 pubmed publisher
Nagashima H, Okuyama Y, Asao A, Kawabe T, Yamaki S, Nakano H, et al. The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol. 2014;15:449-56 pubmed publisher
Silver J, Stumhofer J, Passos S, Ernst M, Hunter C. IL-6 mediates the susceptibility of glycoprotein 130 hypermorphs to Toxoplasma gondii. J Immunol. 2011;187:350-60 pubmed publisher
Liao W, Lin J, Wang L, Li P, Leonard W. Modulation of cytokine receptors by IL-2 broadly regulates differentiation into helper T cell lineages. Nat Immunol. 2011;12:551-9 pubmed publisher
product information
master code :
FAB4681A
SKU :
FAB4681A-100UG
product name :
Mouse gp130 APC-conjugated Antibody
unit size :
100 ug (also 25 ug)
description :
The Mouse gp130 APC-conjugated Antibody from R&D Systems is a rat monoclonal antibody to gp130/CD130. This antibody reacts with mouse. The Mouse gp130 APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
gp130
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
125623
conjugate :
Allophycocyanin
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse gp130, Gln23-Glu617 (predicted), Accession # Q6PDI9
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Mouse
specificity :
Detects mouse gp130 in direct ELISAs and Western blots. In Western blots, no cross-reactivity with recombinant human gp130 is observed.
gene symbol :
IL6ST
top caption :
Detection of gp130 antibody in Mouse Splenocytes antibody by Flow Cytometry.
accessionNumbers :
Q6PDI9
applications :
Flow Cytometry
USD :
449 USD
alt names :
CD130, CD130 antigen, CDw130, DKFZp564F053, gp130, gp130 of the rheumatoid arthritis antigenic peptide-bearing soluble form, IL-6 receptor subunit beta, IL-6R subunit beta, IL-6RB, IL-6R-beta, IL6ST, interleukin 6 signal transducer (gp130, oncostatin M receptor), interleukin receptor beta chain, interleukin-6 receptor subunit beta, Interleukin-6 signal transducer, Membrane glycoprotein 130, membrane glycoprotein gp130, Oncostatin-M receptor subunit alpha
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.