This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
antibody
product name :
Human TRAILR1/TNFRSF10A PE-conjugated Antibody
catalog :
FAB347P
quantity :
25 Tests
price :
149 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
69036
reactivity :
human
application :
flow cytometry
citations: 20
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 5h
Dimberg L, Towers C, Behbakht K, Hotz T, Kim J, Fosmire S, et al. A Genome-Wide Loss-of-Function Screen Identifies SLC26A2 as a Novel Mediator of TRAIL Resistance. Mol Cancer Res. 2017;15:382-394 pubmed publisher
Jo E, Lee Y, Lee H, Park J, Park H, Choi Y, et al. Combination therapy with c-met inhibitor and TRAIL enhances apoptosis in dedifferentiated liposarcoma patient-derived cells. BMC Cancer. 2019;19:496 pubmed publisher
Xu S, Li D, Li T, Qiao L, Li K, Guo L, et al. miR-494 Sensitizes Gastric Cancer Cells to TRAIL Treatment Through Downregulation of Survivin. Cell Physiol Biochem. 2018;51:2212-2223 pubmed publisher
Zhao Y, Tian B, Wang Y, Ding H. Kaempferol Sensitizes Human Ovarian Cancer Cells-OVCAR-3 and SKOV-3 to Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL)-Induced Apoptosis via JNK/ERK-CHOP Pathway and Up-Regulation of Death Receptors 4 and 5. Med Sci Monit. 2017;23:5096-5105 pubmed
Singh H, Otano I, Rombouts K, Singh K, Peppa D, Gill U, et al. TRAIL regulatory receptors constrain human hepatic stellate cell apoptosis. Sci Rep. 2017;7:5514 pubmed publisher
Warat M, Sadowski T, Szliszka E, Krol W, Czuba Z. The role of selected flavonols in tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) expression on activated RAW 264.7 macrophages. Molecules. 2015;20:900-12 pubmed publisher
Warat M, Szliszka E, Korzonek Szlacheta I, Krol W, Czuba Z. Chrysin, apigenin and acacetin inhibit tumor necrosis factor-related apoptosis-inducing ligand receptor-1 (TRAIL-R1) on activated RAW264.7 macrophages. Int J Mol Sci. 2014;15:11510-22 pubmed publisher
Tang X, Lu J, Tu H, Huang K, Fu R, Cao G, et al. TRAIL-engineered bone marrow-derived mesenchymal stem cells: TRAIL expression and cytotoxic effects on C6 glioma cells. Anticancer Res. 2014;34:729-34 pubmed
Kim S, Woo J, Jeong C, Ryu C, Jang J, Jeun S. Potential application of temozolomide in mesenchymal stem cell-based TRAIL gene therapy against malignant glioma. Stem Cells Transl Med. 2014;3:172-82 pubmed publisher
Gupta S, Francis S, Nair M, Mo Y, Aggarwal B. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-C. J Biol Chem. 2013;288:32343-56 pubmed publisher
Gojo I, Tan M, Fang H, Sadowska M, Lapidus R, Baer M, et al. Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, or high-risk acute myeloid leukemia. Clin Cancer Res. 2013;19:1838-51 pubmed publisher
Hong S, Kim H, Kim J, Ha H, Kim Y, Bae E, et al. Smad7 protein induces interferon regulatory factor 1-dependent transcriptional activation of caspase 8 to restore tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. J Biol Chem. 2013;288:3560-70 pubmed publisher
Kalb M, Glaser A, Stary G, Koszik F, Stingl G. TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-?-mediated antitumor reactivity. J Immunol. 2012;188:1583-91 pubmed publisher
Szliszka E, Helewski K, Mizgala E, Krol W. The dietary flavonol fisetin enhances the apoptosis-inducing potential of TRAIL in prostate cancer cells. Int J Oncol. 2011;39:771-9 pubmed publisher
Kang Z, Chen J, Yu Y, Li B, Sun S, Zhang B, et al. Drozitumab, a human antibody to death receptor 5, has potent antitumor activity against rhabdomyosarcoma with the expression of caspase-8 predictive of response. Clin Cancer Res. 2011;17:3181-92 pubmed publisher
Elias A, Siegelin M, Steinmüller A, von Deimling A, Lass U, Korn B, et al. Epigenetic silencing of death receptor 4 mediates tumor necrosis factor-related apoptosis-inducing ligand resistance in gliomas. Clin Cancer Res. 2009;15:5457-65 pubmed publisher
Kim S, Lim J, Park S, Jeong C, Oh J, Jeong M, et al. Gene therapy using TRAIL-secreting human umbilical cord blood-derived mesenchymal stem cells against intracranial glioma. Cancer Res. 2008;68:9614-23 pubmed publisher
Secchiero P, Melloni E, Corallini F, Beltrami A, Alviano F, Milani D, et al. Tumor necrosis factor-related apoptosis-inducing ligand promotes migration of human bone marrow multipotent stromal cells. Stem Cells. 2008;26:2955-63 pubmed publisher
Wu C, Kao C, Safa A. TRAIL recombinant adenovirus triggers robust apoptosis in multidrug-resistant HL-60/Vinc cells preferentially through death receptor DR5. Hum Gene Ther. 2008;19:731-43 pubmed publisher
Dunn C, Brunetto M, Reynolds G, Christophides T, Kennedy P, Lampertico P, et al. Cytokines induced during chronic hepatitis B virus infection promote a pathway for NK cell-mediated liver damage. J Exp Med. 2007;204:667-80 pubmed
product information
brand :
R&D Systems
master code :
FAB347P
SKU :
FAB347P-025
product name :
Human TRAILR1/TNFRSF10A PE-conjugated Antibody
description :
The Human TRAILR1/TNFRSF10A PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to TRAILR1/TNFRSF10A. This antibody reacts with human. The Human TRAILR1/TNFRSF10A PE-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
TRAILR1/TNFRSF10A
category :
Primary Antibodies
unit size :
25 Tests
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
69036
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
S. frugiperda insect ovarian cell line Sf 21-derived recombinant human TRAIL R1/TNFRSF10A, Ala24-Asn239, Accession # AAC51226
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects recombinant human TRAIL R1/TNFRSF10A in direct ELISAs. In direct ELISAs, no cross-reactivity with recombinant human (rh) TRAIL R2, rhTRAIL R3, rhTRAIL R4, or rhDcR3 is observed.
gene symbol :
TNFRSF10A
catalog number base :
FAB347P
accessionNumbers :
AAC51226
applications :
Flow Cytometry
2020 USD :
149
2021 USD :
149 USD
alt names :
APO2, CD261, CD261 antigen, cytotoxic TRAIL receptor, Death receptor 4, DR4, DR4 TRAIL receptor 1, TNF-related apoptosis inducing ligand receptor 1, TNF-related apoptosis-inducing ligand receptor 1, TNFRSF10A, TRAIL R1, TRAIL-R1, TRAILR-1, TRAILR1MGC9365, tumor necrosis factor receptor superfamily member 10A, tumor necrosis factor receptor superfamily, member 10a
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.