product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human Mesothelin PE-conjugated Antibody
catalog :
FAB32652P
quantity :
100 Tests
price :
469 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
420411
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
R&D Systems product webpage
citations: 13
Reference
Quach H, Skovgard M, Villena Vargas J, Bellis R, Chintala N, Amador Molina A, et al. Tumor-Targeted Nonablative Radiation Promotes Solid Tumor CAR T-cell Therapy Efficacy. Cancer Immunol Res. 2023;11:1314-1331 pubmed publisher
Das S, Valton J, Duchateau P, Poirot L. Stromal depletion by TALEN-edited universal hypoimmunogenic FAP-CAR T cells enables infiltration and anti-tumor cytotoxicity of tumor antigen-targeted CAR-T immunotherapy. Front Immunol. 2023;14:1172681 pubmed publisher
Li Y, Brown J, Yu Y, Lee D, Zhou K, Dunn Z, et al. Targeting Immunosuppressive Tumor-Associated Macrophages Using Innate T Cells for Enhanced Antitumor Reactivity. Cancers (Basel). 2022;14: pubmed publisher
Li Y, Yu Y, Kramer A, Hon R, Wilson M, Brown J, et al. An Ex Vivo 3D Tumor Microenvironment-Mimicry Culture to Study TAM Modulation of Cancer Immunotherapy. Cells. 2022;11: pubmed publisher
Good C, Aznar M, Kuramitsu S, Samareh P, Agarwal S, Donahue G, et al. An NK-like CAR T cell transition in CAR T cell dysfunction. Cell. 2021;184:6081-6100.e26 pubmed publisher
Alishah K, Birtel M, Masoumi E, Jafarzadeh L, Mirzaee H, Hadjati J, et al. CRISPR/Cas9-mediated TGFβRII disruption enhances anti-tumor efficacy of human chimeric antigen receptor T cells in vitro. J Transl Med. 2021;19:482 pubmed publisher
Zhang M, Luo J, Sun Q, Harber J, Dawson A, Nakas A, et al. Clonal architecture in mesothelioma is prognostic and shapes the tumour microenvironment. Nat Commun. 2021;12:1751 pubmed publisher
Masoumi E, Jafarzadeh L, Mirzaei H, Alishah K, Fallah Mehrjardi K, Rostamian H, et al. Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells. J Exp Clin Cancer Res. 2020;39:49 pubmed publisher
Zhang E, Yang P, Gu J, Wu H, Chi X, Liu C, et al. Recombination of a dual-CAR-modified T lymphocyte to accurately eliminate pancreatic malignancy. J Hematol Oncol. 2018;11:102 pubmed publisher
Tang Y, Wang Z, Li Z, Kim J, Deng Y, Li Y, et al. High-throughput screening of rare metabolically active tumor cells in pleural effusion and peripheral blood of lung cancer patients. Proc Natl Acad Sci U S A. 2017;114:2544-2549 pubmed publisher
Cherkassky L, Morello A, Villena Vargas J, Feng Y, Dimitrov D, Jones D, et al. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest. 2016;126:3130-44 pubmed publisher
Ter Weele E, Terwisscha van Scheltinga A, Kosterink J, Pot L, Vedelaar S, Lamberts L, et al. Imaging the distribution of an antibody-drug conjugate constituent targeting mesothelin with ⁸⁹Zr and IRDye 800CW in mice bearing human pancreatic tumor xenografts. Oncotarget. 2015;6:42081-90 pubmed publisher
Servais E, Suzuki K, Colovos C, Rodriguez L, Sima C, Fleisher M, et al. An in vivo platform for tumor biomarker assessment. PLoS ONE. 2011;6:e26722 pubmed publisher
product information
brand :
R&D Systems
master code :
FAB32652P
SKU :
FAB32652P
product name :
Human Mesothelin PE-conjugated Antibody
unit size :
100 Tests
seo description :
The Human Mesothelin PE-conjugated Antibody from R&D Systems is a rat monoclonal antibody to Mesothelin. This antibody reacts with human,mouse. The Human Mesothelin PE-conjugated Antibody has been validated for the following applications: CAR-T (Flow Cytometry),Flow Cytometry,Immunocytochemistry,Knockout Validated.
target :
Mesothelin
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
420411
conjugate :
Phycoerythrin
dilution :
Flow Cytometry 10 uL/10^6 cells, Knockout Validated 10 uL/10^6 cells
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human Mesothelin, Glu296-Gly580, Accession # AAH09272
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human Mesothelin in direct ELISAs.
gene symbol :
MSLN
Antibody validation :
Knockout/Knockdown
top caption :
Detection of Mesothelin antibody in HeLa Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
AAH09272
applications :
Knockout Validated,CAR-T (Flow Cytometry),Flow Cytometry,Immunocytochemistry
USD :
469 USD
alt names :
CAK1, CAK1 antigen, megakaryocyte potentiating factor, mesothelin, MPF, MPFSMRP, MSLN, Pre-pro-megakaryocyte-potentiating factor, SMR, soluble MPF mesothelin related protein
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.