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company name :
R&D Systems
product type :
antibody
product name :
Human TIM-3 PE-conjugated Antibody
catalog :
FAB2365P
quantity :
100 Tests
price :
479 USD
clonality :
monoclonal
host :
rat
conjugate :
PE
clone name :
344823
reactivity :
human, dogs
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 37
Reference
Urak R, Gittins B, Soemardy C, Grepo N, Goldberg L, Maker M, et al. Evaluation of the Elements of Short Hairpin RNAs in Developing shRNA-Containing CAR T Cells. Cancers (Basel). 2023;15: pubmed publisher
Smith C, Li A, Krishnamurthy N, Lemmon M. Phosphatidylserine binding directly regulates TIM-3 function. Biochem J. 2021;478:3331-3349 pubmed publisher
Lee M, Yun S, Lee B, Jeong E, Yoon G, Kim K, et al. Association of TIM-3 expression with glucose metabolism in Jurkat T cells. BMC Immunol. 2020;21:48 pubmed publisher
Meggyes M, Szereday L, Bohonyi N, Koppan M, Szegedi S, Marics Kutas A, et al. Different Expression Pattern of TIM-3 and Galectin-9 Molecules by Peripheral and Peritoneal Lymphocytes in Women with and without Endometriosis. Int J Mol Sci. 2020;21: pubmed publisher
Chapuis A, Egan D, Bar M, Schmitt T, McAfee M, Paulson K, et al. T cell receptor gene therapy targeting WT1 prevents acute myeloid leukemia relapse post-transplant. Nat Med. 2019;: pubmed publisher
Duhen T, Duhen R, Montler R, Moses J, Moudgil T, de Miranda N, et al. Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors. Nat Commun. 2018;9:2724 pubmed publisher
Roboz G, Ritchie E, Dault Y, Lam L, Marshall D, Cruz N, et al. Phase I trial of plerixafor combined with decitabine in newly diagnosed older patients with acute myeloid leukemia. Haematologica. 2018;103:1308-1316 pubmed publisher
Lichtenegger F, Rothe M, Schnorfeil F, Deiser K, Krupka C, Augsberger C, et al. Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells. Front Immunol. 2018;9:385 pubmed publisher
Zhao D, Guo M, Liu B, Lin Q, Xie T, Zhang Q, et al. Frontline Science: Tim-3-mediated dysfunctional engulfment of apoptotic cells in SLE. J Leukoc Biol. 2017;102:1313-1322 pubmed publisher
Allard M, Couturaud B, Carretero Iglesia L, Duong M, Schmidt J, Monnot G, et al. TCR-ligand dissociation rate is a robust and stable biomarker of CD8+ T cell potency. JCI Insight. 2017;2: pubmed publisher
Schofield L, Ioannidis L, Karl S, Robinson L, Tan Q, Poole D, et al. Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of ?? T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea. BMC Med. 2017;15:114 pubmed publisher
Stecher C, Battin C, Leitner J, Zettl M, Grabmeier Pfistershammer K, Höller C, et al. PD-1 Blockade Promotes Emerging Checkpoint Inhibitors in Enhancing T Cell Responses to Allogeneic Dendritic Cells. Front Immunol. 2017;8:572 pubmed publisher
Gasper M, Hesseling A, Mohar I, Myer L, Azenkot T, Passmore J, et al. BCG vaccination induces HIV target cell activation in HIV-exposed infants in a randomized trial. JCI Insight. 2017;2:e91963 pubmed publisher
Schwartz J, Clayton K, Mujib S, Zhang H, Rahman A, Liu J, et al. Tim-3 is a Marker of Plasmacytoid Dendritic Cell Dysfunction during HIV Infection and Is Associated with the Recruitment of IRF7 and p85 into Lysosomes and with the Submembrane Displacement of TLR9. J Immunol. 2017;198:3181-3194 pubmed publisher
Kongsted P, Borch T, Ellebaek E, Iversen T, Andersen R, Met O, et al. Dendritic cell vaccination in combination with docetaxel for patients with metastatic castration-resistant prostate cancer: A randomized phase II study. Cytotherapy. 2017;19:500-513 pubmed publisher
Franzese O, Palermo B, Di Donna C, Sperduti I, Ferraresi V, Stabile H, et al. Polyfunctional Melan-A-specific tumor-reactive CD8(+) T cells elicited by dacarbazine treatment before peptide-vaccination depends on AKT activation sustained by ICOS. Oncoimmunology. 2016;5:e1114203 pubmed publisher
Cherkassky L, Morello A, Villena Vargas J, Feng Y, Dimitrov D, Jones D, et al. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J Clin Invest. 2016;126:3130-44 pubmed publisher
Tian G, Courtney A, Jena B, Heczey A, Liu D, Marinova E, et al. CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo. J Clin Invest. 2016;126:2341-55 pubmed publisher
Guo C, Shen X, Fu B, Liu Y, Chen Y, Ni F, et al. CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients. Sci Rep. 2016;6:25567 pubmed publisher
Liu Z, Han H, He X, Li S, Wu C, Yu C, et al. Expression of the galectin-9-Tim-3 pathway in glioma tissues is associated with the clinical manifestations of glioma. Oncol Lett. 2016;11:1829-1834 pubmed
Clark G, Kupresanin F, Fromm P, Ju X, Muusers L, Silveira P, et al. New insights into the phenotype of human dendritic cell populations. Clin Transl Immunology. 2016;5:e61 pubmed publisher
Pabst C, Bergeron A, Lavallée V, Yeh J, Gendron P, Norddahl G, et al. GPR56 identifies primary human acute myeloid leukemia cells with high repopulating potential in vivo. Blood. 2016;127:2018-27 pubmed publisher
Frederiksen J, Buggert M, Noyan K, Nowak P, Sönnerborg A, Lund O, et al. Multidimensional Clusters of CD4+ T Cell Dysfunction Are Primarily Associated with the CD4/CD8 Ratio in Chronic HIV Infection. PLoS ONE. 2015;10:e0137635 pubmed publisher
Kared H, Saeed S, Klein M, Shoukry N. CD127 expression, exhaustion status and antigen specific proliferation predict sustained virologic response to IFN in HCV/HIV co-infected individuals. PLoS ONE. 2014;9:e101441 pubmed publisher
Meggyes M, Miko E, Polgar B, Bogar B, Farkas B, Illes Z, et al. Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy. PLoS ONE. 2014;9:e92371 pubmed publisher
Lanteri M, Diamond M, Law J, Chew G, Wu S, Inglis H, et al. Increased frequency of Tim-3 expressing T cells is associated with symptomatic West Nile virus infection. PLoS ONE. 2014;9:e92134 pubmed publisher
Herath S, Benlahrech A, Papagatsias T, Athanasopoulos T, Bouzeboudjen Z, Hervouet C, et al. Fusion of ubiquitin to HIV gag impairs human monocyte-derived dendritic cell maturation and reduces ability to induce gag T cell responses. PLoS ONE. 2014;9:e88327 pubmed publisher
Clayton K, Haaland M, Douglas Vail M, Mujib S, Chew G, Ndhlovu L, et al. T cell Ig and mucin domain-containing protein 3 is recruited to the immune synapse, disrupts stable synapse formation, and associates with receptor phosphatases. J Immunol. 2014;192:782-91 pubmed publisher
Michael H, Ito D, McCullar V, Zhang B, Miller J, Modiano J. Isolation and characterization of canine natural killer cells. Vet Immunol Immunopathol. 2013;155:211-7 pubmed publisher
Mansfield A, Nevala W, Lieser E, Leontovich A, Markovic S. The immunomodulatory effects of bevacizumab on systemic immunity in patients with metastatic melanoma. Oncoimmunology. 2013;2:e24436 pubmed
Nebbia G, Peppa D, Schurich A, Khanna P, Singh H, Cheng Y, et al. Upregulation of the Tim-3/galectin-9 pathway of T cell exhaustion in chronic hepatitis B virus infection. PLoS ONE. 2012;7:e47648 pubmed publisher
Tandon R, Giret M, SenGupta D, York V, Wiznia A, Rosenberg M, et al. Age-related expansion of Tim-3 expressing T cells in vertically HIV-1 infected children. PLoS ONE. 2012;7:e45733 pubmed publisher
Sakhdari A, Mujib S, Vali B, Yue F, Macparland S, Clayton K, et al. Tim-3 negatively regulates cytotoxicity in exhausted CD8+ T cells in HIV infection. PLoS ONE. 2012;7:e40146 pubmed publisher
Mujib S, Jones R, Lo C, Aidarus N, Clayton K, Sakhdari A, et al. Antigen-independent induction of Tim-3 expression on human T cells by the common ?-chain cytokines IL-2, IL-7, IL-15, and IL-21 is associated with proliferation and is dependent on the phosphoinositide 3-kinase pathway. J Immunol. 2012;188:3745-56 pubmed publisher
Baitsch L, Legat A, Barba L, Fuertes Marraco S, Rivals J, Baumgaertner P, et al. Extended co-expression of inhibitory receptors by human CD8 T-cells depending on differentiation, antigen-specificity and anatomical localization. PLoS ONE. 2012;7:e30852 pubmed publisher
Antonelli L, Mahnke Y, Hodge J, Porter B, Barber D, DerSimonian R, et al. Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome. Blood. 2010;116:3818-27 pubmed publisher
Idali F, Wahlstrom J, Dahlberg B, Khademi M, Olsson T, Eklund A, et al. Altered expression of T cell immunoglobulin-mucin (TIM) molecules in bronchoalveolar lavage CD4+ T cells in sarcoidosis. Respir Res. 2009;10:42 pubmed publisher
product information
master code :
FAB2365P
SKU :
FAB2365P
product name :
Human TIM-3 PE-conjugated Antibody
unit size :
100 Tests
description :
The Human TIM-3 PE-conjugated Antibody from R&D Systems is a rat monoclonal antibody to TIM-3. This antibody reacts with canine,human. The Human TIM-3 PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,Immunocytochemistry.
target :
TIM-3
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
344823
conjugate :
Phycoerythrin
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant human TIM-3, Ser22-Arg200, Accession # Q8TDQ0.2
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Canine,Human
specificity :
Detects human TIM-3 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) TIM-1, rhTIM-4, recombinant mouse (rm) TIM-1, rmTIM-2, rmTIM-3, rmTIM-5, or rmTIM-6.
gene symbol :
HAVCR2
top caption :
Detection of TIM-3 antibody in Human Blood Monocytes antibody by Flow Cytometry.
accessionNumbers :
Q8TDQ0.2
applications :
Flow Cytometry,Immunocytochemistry
extended description :
Clone 344823 was used by HLDA to establish CD designation
USD :
479 USD
product details :
Clone 344823 was used by HLDA to establish CD designation
alt names :
CD366, FLJ14428, HAVcr-2, HAVCR2, hepatitis A virus cellular receptor 2, kidney injury molecule-3, KIM-3, SPTCL, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain-containing protein 3, TIM 3, Tim-3, TIM3, TIM3 T-cell membrane protein 3, TIMD3, TIMD-3, TIMD3KIM-3
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.