Human TIM-3 APC-conjugated Antibody | R&D Systems FAB2365A product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human TIM-3 APC-conjugated Antibody

catalog :

FAB2365A

quantity :

100 Tests

price :

499 USD

clonality :

monoclonal

host :

rat

conjugate :

APC

clone name :

344823

reactivity :

human

application :

flow cytometry

more info or order :

R&D Systems product webpage

citations: 15

Reference
Vos J, Burman B, Jain S, Fitzgerald C, Sherman E, Dunn L, et al. Nivolumab plus ipilimumab in advanced salivary gland cancer: a phase 2 trial. Nat Med. 2023;29:3077-3089 pubmed publisher
Ahmed R, Lozano L, Anastasio A, Lofek S, Mastelic Gavillet B, Navarro Rodrigo B, et al. Phenotype and Reactivity of Lymphocytes Expanded from Benign Prostate Hyperplasic Tissues and Prostate Cancer. Cancers (Basel). 2023;15: pubmed publisher
Meggyes M, Nagy D, Balassa T, Godony K, Peterfalvi A, Szereday L, et al. Influence of Galectin-9 Treatment on the Phenotype and Function of NK-92MI Cells in the Presence of Different Serum Supplements. Biomolecules. 2021;11: pubmed publisher
Lo Presti V, Cornel A, Plantinga M, D xfc nnebach E, Kuball J, Boelens J, et al. Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications. Mol Ther Methods Clin Dev. 2021;21:357-368 pubmed publisher
Naing A, Infante J, Papadopoulos K, Chan I, Shen C, Ratti N, et al. PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients. Cancer Cell. 2018;34:775-791.e3 pubmed publisher
Fourcade J, Sun Z, Chauvin J, Ka M, Davar D, Pagliano O, et al. CD226 opposes TIGIT to disrupt Tregs in melanoma. JCI Insight. 2018;3: pubmed publisher
D Angelo S, Melchiori L, Merchant M, Bernstein D, Glod J, Kaplan R, et al. Antitumor Activity Associated with Prolonged Persistence of Adoptively Transferred NY-ESO-1 c259T Cells in Synovial Sarcoma. Cancer Discov. 2018;8:944-957 pubmed publisher
Huang A, Postow M, Orlowski R, Mick R, Bengsch B, Manne S, et al. T-cell invigoration to tumour burden ratio associated with anti-PD-1 response. Nature. 2017;545:60-65 pubmed publisher
Wu W, Zheng Y, Tian L, Lai J, Hu C, Zhang P, et al. Circulating T lymphocyte subsets, cytokines, and immune checkpoint inhibitors in patients with bipolar II or major depression: a preliminary study. Sci Rep. 2017;7:40530 pubmed publisher
Folgiero V, Cifaldi L, Li Pira G, Goffredo B, Vinti L, Locatelli F. TIM-3/Gal-9 interaction induces IFNÎ³-dependent IDO1 expression in acute myeloid leukemia blast cells. J Hematol Oncol. 2015;8:36 pubmed publisher
Raziorrouh B, Heeg M, Kurktschiev P, Schraut W, Zachoval R, Wendtner C, et al. Inhibitory phenotype of HBV-specific CD4+ T-cells is characterized by high PD-1 expression but absent coregulation of multiple inhibitory molecules. PLoS ONE. 2014;9:e105703 pubmed publisher
Meggyes M, Miko E, Polgar B, Bogar B, Farkas B, Illes Z, et al. Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy: TIM-3/galectin-9 interaction and its possible role during pregnancy. PLoS ONE. 2014;9:e92371 pubmed publisher
Wang J, Shi L, Ma C, Ji X, Ying R, Wu X, et al. Differential regulation of interleukin-12 (IL-12)/IL-23 by Tim-3 drives T(H)17 cell development during hepatitis C virus infection. J Virol. 2013;87:4372-83 pubmed publisher
Wu W, Shi Y, Li S, Zhang Y, Liu Y, Wu Y, et al. Blockade of Tim-3 signaling restores the virus-specific CD8? T-cell response in patients with chronic hepatitis B. Eur J Immunol. 2012;42:1180-91 pubmed publisher
Zhang Y, Ma C, Wang J, Ji X, Wu X, Jia Z, et al. Tim-3 negatively regulates IL-12 expression by monocytes in HCV infection. PLoS ONE. 2011;6:e19664 pubmed publisher

product information

master code :

FAB2365A

SKU :

FAB2365A

product name :

Human TIM-3 APC-conjugated Antibody

unit size :

100 Tests

description :

The Human TIM-3 APC-conjugated Antibody from R&D Systems is a rat monoclonal antibody to TIM-3. This antibody reacts with human. The Human TIM-3 APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.

target :

TIM-3

category :

Primary Antibodies

buffer :

Supplied in a saline solution containing BSA and Sodium Azide.

clonality :

Monoclonal

clone :

344823

conjugate :

Allophycocyanin

host :

Rat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human TIM-3, Ser22-Arg200, Accession # Q8TDQ0.2

isotype :

IgG2a

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human TIM-3 in direct ELISAs and Western blots. Does not cross-react with recombinant human (rh) TIM-1, rhTIM-4, recombinant mouse (rm) TIM-1, rmTIM-2, rmTIM-3, rmTIM-5, or rmTIM-6.

gene symbol :

HAVCR2

top caption :

Detection of TIM-3 antibody in Human Blood Monocytes antibody by Flow Cytometry.

accessionNumbers :

Q8TDQ0.2

applications :

Flow Cytometry

extended description :

Clone 344823 was used by HLDA to establish CD designation

USD :

499 USD

product details :

Clone 344823 was used by HLDA to establish CD designation

alt names :

CD366, FLJ14428, HAVcr-2, HAVCR2, hepatitis A virus cellular receptor 2, kidney injury molecule-3, KIM-3, SPTCL, T cell immunoglobulin mucin 3, T cell immunoglobulin mucin-3, T-cell immunoglobulin and mucin domain-containing protein 3, TIM 3, Tim-3, TIM3, TIM3 T-cell membrane protein 3, TIMD3, TIMD-3, TIMD3KIM-3

storage :

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.

more info or order :

R&D Systems product webpage