Human LAG-3 PE-conjugated Antibody | R&D Systems FAB2319P product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human LAG-3 PE-conjugated Antibody

catalog :

FAB2319P

quantity :

100 Tests

price :

469 USD

clonality :

polyclonal

host :

domestic goat

conjugate :

reactivity :

human, mouse, rhesus macaque

application :

flow cytometry

more info or order :

R&D Systems product webpage

citations: 11

Reference
Bruss C, Kellner K, Albert V, Hutchinson J, Seitz S, Ortmann O, et al. Immune Checkpoint Profiling in Humanized Breast Cancer Mice Revealed Cell-Specific LAG-3/PD-1/TIM-3 Co-Expression and Elevated PD-1/TIM-3 Secretion. Cancers (Basel). 2023;15: pubmed publisher
Kimman T, Slomp A, Martens A, Grabherr S, Li S, van Diest E, et al. Serpin B9 controls tumor cell killing by CAR T cells. J Immunother Cancer. 2023;11: pubmed publisher
Hebbar N, Epperly R, Vaidya A, Thanekar U, Moore S, Umeda M, et al. CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells. Nat Commun. 2022;13:587 pubmed publisher
Nugent J, Singh A, Wirth K, Oppler S, Hocum Stone L, Janecek J, et al. A nonhuman primate model of vertical sleeve gastrectomy facilitates mechanistic and translational research in human obesity. iScience. 2021;24:103421 pubmed publisher
Lo Presti V, Cornel A, Plantinga M, D xfc nnebach E, Kuball J, Boelens J, et al. Efficient lentiviral transduction method to gene modify cord blood CD8+ T cells for cancer therapy applications. Mol Ther Methods Clin Dev. 2021;21:357-368 pubmed publisher
Singh D, Singh B, Ganatra S, Gazi M, Cole J, Thippeshappa R, et al. Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Nat Microbiol. 2021;6:73-86 pubmed publisher
Kobayashi Y, Yamada D, Kawai T, Sato Y, Teshima T, Yamada Y, et al. Different immunological effects of the molecular targeted agents sunitinib, everolimus and temsirolimus in patients with renal cell carcinoma. Int J Oncol. 2020;56:999-1013 pubmed publisher
Nakachi S, Sumitomo S, Tsuchida Y, Tsuchiya H, Kono M, Kato R, et al. Interleukin-10-producing LAG3+ regulatory T cells are associated with disease activity and abatacept treatment in rheumatoid arthritis. Arthritis Res Ther. 2017;19:97 pubmed publisher
Huang R, Francois A, McGray A, Miliotto A, Odunsi K. Compensatory upregulation of PD-1, LAG-3, and CTLA-4 limits the efficacy of single-agent checkpoint blockade in metastatic ovarian cancer. Oncoimmunology. 2017;6:e1249561 pubmed publisher
Melve G, Ersvaer E, Akkök C, Ahmed A, Kristoffersen E, Hervig T, et al. Immunomodulation Induced by Stem Cell Mobilization and Harvesting in Healthy Donors: Increased Systemic Osteopontin Levels after Treatment with Granulocyte Colony-Stimulating Factor. Int J Mol Sci. 2016;17: pubmed publisher
Tian G, Courtney A, Jena B, Heczey A, Liu D, Marinova E, et al. CD62L+ NKT cells have prolonged persistence and antitumor activity in vivo. J Clin Invest. 2016;126:2341-55 pubmed publisher

product information

master code :

FAB2319P

SKU :

FAB2319P

product name :

Human LAG-3 PE-conjugated Antibody

unit size :

100 Tests

description :

The Human LAG-3 PE-conjugated Antibody from R&D Systems is a goat polyclonal antibody to LAG-3. This antibody reacts with human,mouse,primate - macaca mulatta (rhesus macaque),xenograft. The Human LAG-3 PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,Bioassay.

target :

LAG-3

category :

Primary Antibodies

buffer :

Supplied in a saline solution containing BSA and Sodium Azide.

clonality :

Polyclonal

conjugate :

Phycoerythrin

host :

Goat

immunogen :

Mouse myeloma cell line NS0-derived recombinant human LAG-3, Leu23-Leu450, Accession # P18627

isotype :

IgG

purity :

Antigen Affinity-purified

species :

Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Xenograft

specificity :

Detects human LAG-3 in direct ELISAs and Western blots. In direct ELISAs and Western blots, less than 1% cross-reactivity with recombinant mouse LAG-3 is observed.

gene symbol :

LAG3

top caption :

Detection of LAG-3 antibody in HEK293 Human Cell Line Transfected with Human LAG-3 and eGFP antibody by Flow Cytometry.

accessionNumbers :

P18627

applications :

Flow Cytometry,Bioassay

USD :

469 USD

alt names :

CD223, CD223 antigen, LAG3, LAG-3, lymphocyte activating 3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Secreted lymphocyte activation gene 3 protein, sLAG-3

storage :

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.

more info or order :

R&D Systems product webpage