product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human TNF RI/TNFRSF1A PE-conjugated Antibody
catalog :
FAB225P
quantity :
100 Tests
price :
409 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
16803
reactivity :
human, mouse
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 25
Reference
Alshevskaya A, Lopatnikova J, Zhukova J, Perik Zavodskaia O, Alrhmoun S, Obleukhova I, et al. TNFR1 Absence Is Not Crucial for Different Types of Cell Reaction to TNF: A Study of the TNFR1-Knockout Cell Model. Epigenomes. 2024;8: pubmed publisher
Perik Zavodskaia O, Alrhmoun S, Perik Zavodskii R, Zhukova J, Lopatnikova J, Volynets M, et al. Knockouts of TNFRSF1A and TNFRSF1B Genes in K562 Cell Line Lead to Diverse Long-Lasting Responses to TNF-α. Int J Mol Sci. 2023;24: pubmed publisher
Alshevskaya A, Lopatnikova J, Zhukova J, Chumasova O, Shkaruba N, Sizikov A, et al. The Influence of Severity and Disease Duration on TNF Receptors' Redistribution in Asthma and Rheumatoid Arthritis. Cells. 2022;12: pubmed publisher
Cruz J, Mokashi C, Kowalczyk G, Guo Y, Zhang Q, Gupta S, et al. A variable-gain stochastic pooling motif mediates information transfer from receptor assemblies into NF-κB. Sci Adv. 2021;7: pubmed publisher
Twomey J, Zhang B. Circulating Tumor Cells Develop Resistance to TRAIL-Induced Apoptosis Through Autophagic Removal of Death Receptor 5: Evidence from an In Vitro Model. Cancers (Basel). 2019;11: pubmed publisher
McCann C, Crawford N, Majkut J, Holohan C, Armstrong C, Maxwell P, et al. Cytoplasmic FLIP(S) and nuclear FLIP(L) mediate resistance of castrate-resistant prostate cancer to apoptosis induced by IAP antagonists. Cell Death Dis. 2018;9:1081 pubmed publisher
Fauster A, Rebsamen M, Willmann K, César Razquin A, Girardi E, Bigenzahn J, et al. Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking. Cell Death Differ. 2019;26:1138-1155 pubmed publisher
Fairclough L, Stoop A, Negm O, Radford P, Tighe P, Todd I. Tumour necrosis factor receptor I blockade shows that TNF-dependent and TNF-independent mechanisms synergise in TNF receptor associated periodic syndrome. Eur J Immunol. 2015;45:2937-44 pubmed publisher
Tufa D, Chatterjee D, Low H, Schmidt R, Jacobs R. TNFR2 and IL-12 coactivation enables slanDCs to support NK-cell function via membrane-bound TNF-α. Eur J Immunol. 2014;44:3717-28 pubmed publisher
Sennikov S, Vasilyev F, Lopatnikova J, Shkaruba N, Silkov A. Polymorphisms in the tumor necrosis factor receptor genes affect the expression levels of membrane-bound type I and type II receptors. Mediators Inflamm. 2014;2014:745909 pubmed publisher
Ruspi G, Schmidt E, McCann F, Feldmann M, Williams R, Stoop A, et al. TNFR2 increases the sensitivity of ligand-induced activation of the p38 MAPK and NF-?B pathways and signals TRAF2 protein degradation in macrophages. Cell Signal. 2014;26:683-90 pubmed publisher
Jeru I, Charmion S, Cochet E, Copin B, Duquesnoy P, Garcia M, et al. Involvement of the same TNFR1 residue in mendelian and multifactorial inflammatory disorders. PLoS ONE. 2013;8:e69757 pubmed publisher
Cosgrove C, Ussher J, Rauch A, Gärtner K, Kurioka A, Hühn M, et al. Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection. Blood. 2013;121:951-61 pubmed publisher
Chen J, Shen H, Rivera Rosado L, Zhang Y, Di X, Zhang B. Mislocalization of death receptors correlates with cellular resistance to their cognate ligands in human breast cancer cells. Oncotarget. 2012;3:833-42 pubmed
Johansson A, Nandakumar K, Persson A, Olsson I, Hansson M. Secretory lysosome targeting and induced secretion of human soluble TNF-alpha receptor in murine hematopoietic cells in vivo as a principle for immunoregulation in inflammation and malignancy. Exp Hematol. 2009;37:969-78 pubmed publisher
Nydam T, Moore E, McIntyre R, Wright F, Gamboni Robertson F, Eckels P, et al. Hypertonic saline attenuates TNF-alpha-induced NF-kappaB activation in pulmonary epithelial cells. Shock. 2009;31:466-72 pubmed publisher
Liu L, Bates M, Jarjour N, Busse W, Bertics P, Kelly E. Generation of Th1 and Th2 chemokines by human eosinophils: evidence for a critical role of TNF-alpha. J Immunol. 2007;179:4840-8 pubmed
Rossol M, Meusch U, Pierer M, Kaltenhäuser S, Hantzschel H, Hauschildt S, et al. Interaction between transmembrane TNF and TNFR1/2 mediates the activation of monocytes by contact with T cells. J Immunol. 2007;179:4239-48 pubmed
Montag C, Wagner J, Gruska I, Hagemeier C. Human cytomegalovirus blocks tumor necrosis factor alpha- and interleukin-1beta-mediated NF-kappaB signaling. J Virol. 2006;80:11686-98 pubmed
Rebelo S, Bainbridge S, Amel Kashipaz M, Radford P, Powell R, Todd I, et al. Modeling of tumor necrosis factor receptor superfamily 1A mutants associated with tumor necrosis factor receptor-associated periodic syndrome indicates misfolding consistent with abnormal function. Arthritis Rheum. 2006;54:2674-87 pubmed
D Osualdo A, Ferlito F, Prigione I, Obici L, Meini A, Zulian F, et al. Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications. Arthritis Rheum. 2006;54:998-1008 pubmed
Saito K, Hirokawa M, Inaba K, Fukaya H, Kawabata Y, Komatsuda A, et al. Phagocytosis of codeveloping megakaryocytic progenitors by dendritic cells in culture with thrombopoietin and tumor necrosis factor-alpha and its possible role in hemophagocytic syndrome. Blood. 2006;107:1366-74 pubmed
Fukaya H, Xiao W, Inaba K, Suzuki Y, Hirokawa M, Kawabata Y, et al. Codevelopment of dendritic cells along with erythroid differentiation from human CD34(+) cells by tumor necrosis factor-alpha. Exp Hematol. 2004;32:450-60 pubmed
Xiao W, Koizumi K, Nishio M, Endo T, Osawa M, Fujimoto K, et al. Tumor necrosis factor-alpha inhibits generation of glycophorin A+ cells by CD34+ cells. Exp Hematol. 2002;30:1238-47 pubmed
Segura I, Serrano A, de Buitrago G, Gonzalez M, Abad J, Claveria C, et al. Inhibition of programmed cell death impairs in vitro vascular-like structure formation and reduces in vivo angiogenesis. FASEB J. 2002;16:833-41 pubmed
product information
master code :
FAB225P
SKU :
FAB225P
product name :
Human TNF RI/TNFRSF1A PE-conjugated Antibody
unit size :
100 Tests
description :
The Human TNF RI/TNFRSF1A PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to TNF RI/TNFRSF1A. This antibody reacts with human,mouse. The Human TNF RI/TNFRSF1A PE-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
TNF RI/TNFRSF1A
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
16803
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
E. coli -derived recombinant human TNF RI/TNFRSF1A, Accession # NP_001056
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human TNF RI in Western blots. In Western blots, does not cross-react with recombinant human TNF RII, recombinant mouse (rm) TNF RI, or rmTNF RII.
gene symbol :
TNFRSF1A
top caption :
Detection of TNF RI/TNFRSF1A antibody in Human Blood Monocytes antibody by Flow Cytometry.
accessionNumbers :
NP_001056
applications :
Flow Cytometry
USD :
409 USD
alt names :
CD120a, CD120a antigen, FPF, p55, p55-R, p60, TNFARMGC19588, TNF-R, TNF-R1, TNFR1TBP1, TNFR55, TNF-R55, TNFR60, TNFRI, TNF-RI, TNF-R-I, TNFR-I, TNFRSF1A, tumor necrosis factor binding protein 1, Tumor necrosis factor receptor 1, tumor necrosis factor receptor 1A isoform beta, tumor necrosis factor receptor superfamily member 1A, tumor necrosis factor receptor superfamily, member 1A, tumor necrosis factor receptor type 1, Tumor necrosis factor receptor type I, tumor necrosis factor-alpha receptor
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.