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company name :
R&D Systems
product type :
antibody
product name :
Human CCR7 Fluorescein-conjugated Antibody
catalog :
FAB197F-025
quantity :
25 Tests (also 100 Tests)
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
150503
reactivity :
human, rhesus macaque
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 75
Reference
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Gary R, Aigner M, Moi S, Schäffer S, Gottmann A, Maas S, et al. Clinical-grade generation of peptide-stimulated CMV/EBV-specific T cells from G-CSF mobilized stem cell grafts. J Transl Med. 2018;16:124 pubmed publisher
Chiu Y, Tsai C, Kao J, Hsieh C, Shieh D, Lee Y, et al. PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma. Anticancer Res. 2018;38:2069-2078 pubmed
Gavegnano C, Brehm J, Dupuy F, Talla A, Ribeiro S, Kulpa D, et al. Novel mechanisms to inhibit HIV reservoir seeding using Jak inhibitors. PLoS Pathog. 2017;13:e1006740 pubmed publisher
Kansy B, Concha Benavente F, Srivastava R, Jie H, Shayan G, Lei Y, et al. PD-1 Status in CD8+ T Cells Associates with Survival and Anti-PD-1 Therapeutic Outcomes in Head and Neck Cancer. Cancer Res. 2017;77:6353-6364 pubmed publisher
Stenberg L, Stößel M, Ronchi G, Geuna S, Yin Y, Mommert S, et al. Regeneration of long-distance peripheral nerve defects after delayed reconstruction in healthy and diabetic rats is supported by immunomodulatory chitosan nerve guides. BMC Neurosci. 2017;18:53 pubmed publisher
Hazeldine J, Naumann D, Toman E, Davies D, Bishop J, Su Z, et al. Prehospital immune responses and development of multiple organ dysfunction syndrome following traumatic injury: A prospective cohort study. PLoS Med. 2017;14:e1002338 pubmed publisher
Huang L, Litjens N, Kannegieter N, Klepper M, Baan C, Betjes M. pERK-dependent defective TCR-mediated activation of CD4+ T cells in end-stage renal disease patients. Immun Ageing. 2017;14:14 pubmed publisher
Rea D, Henry G, Khaznadar Z, Etienne G, Guilhot F, Nicolini F, et al. Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study. Haematologica. 2017;102:1368-1377 pubmed publisher
Godbersen C, Coupet T, Huehls A, Zhang T, Battles M, Fisher J, et al. NKG2D Ligand-Targeted Bispecific T-Cell Engagers Lead to Robust Antitumor Activity against Diverse Human Tumors. Mol Cancer Ther. 2017;16:1335-1346 pubmed publisher
Whilding L, Parente Pereira A, Zabinski T, Davies D, Petrovic R, Kao Y, et al. Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells. Mol Ther. 2017;25:259-273 pubmed publisher
Li J, Shayan G, Avery L, Jie H, Gildener Leapman N, Schmitt N, et al. Tumor-infiltrating Tim-3+ T cells proliferate avidly except when PD-1 is co-expressed: Evidence for intracellular cross talk. Oncoimmunology. 2016;5:e1200778 pubmed
Maghazachi A, Sand K, Al Jaderi Z. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity. Front Immunol. 2016;7:437 pubmed
Xu Y, Chaudhury A, Zhang M, Savoldo B, Metelitsa L, Rodgers J, et al. Glycolysis determines dichotomous regulation of T cell subsets in hypoxia. J Clin Invest. 2016;126:2678-88 pubmed publisher
Li H, Wang S, Kong R, Ding W, Lee F, Parker Z, et al. Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques. Proc Natl Acad Sci U S A. 2016;113:E3413-22 pubmed publisher
Smith K, Mailliard R, Piazza P, Fischer W, Korber B, Fecek R, et al. Effective Cytotoxic T Lymphocyte Targeting of Persistent HIV-1 during Antiretroviral Therapy Requires Priming of Naive CD8+ T Cells. MBio. 2016;7: pubmed publisher
De Rosa V, Galgani M, Porcellini A, Colamatteo A, Santopaolo M, Zuchegna C, et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat Immunol. 2015;16:1174-84 pubmed publisher
Hudspeth K, Donadon M, Cimino M, Pontarini E, Tentorio P, Preti M, et al. Human liver-resident CD56(bright)/CD16(neg) NK cells are retained within hepatic sinusoids via the engagement of CCR5 and CXCR6 pathways. J Autoimmun. 2016;66:40-50 pubmed publisher
Santra S, Tomaras G, Warrier R, Nicely N, Liao H, Pollara J, et al. Human Non-neutralizing HIV-1 Envelope Monoclonal Antibodies Limit the Number of Founder Viruses during SHIV Mucosal Infection in Rhesus Macaques. PLoS Pathog. 2015;11:e1005042 pubmed publisher
Thomas S, Klobuch S, Podlech J, Plachter B, Hoffmann P, Renzaho A, et al. Evaluating Human T-Cell Therapy of Cytomegalovirus Organ Disease in HLA-Transgenic Mice. PLoS Pathog. 2015;11:e1005049 pubmed publisher
de Mare Bredemeijer E, Shi X, Mancham S, van Gent R, van der Heide Mulder M, de Boer R, et al. Cytomegalovirus-Induced Expression of CD244 after Liver Transplantation Is Associated with CD8+ T Cell Hyporesponsiveness to Alloantigen. J Immunol. 2015;195:1838-48 pubmed publisher
Wilson R, Ives M, Rao G, Lau A, Payne K, Kobayashi M, et al. STAT3 is a critical cell-intrinsic regulator of human unconventional T cell numbers and function. J Exp Med. 2015;212:855-64 pubmed publisher
Costa M, Cruz E, Oliveira S, Benes V, Ivacevic T, Silva M, et al. Lymphocyte gene expression signatures from patients and mouse models of hereditary hemochromatosis reveal a function of HFE as a negative regulator of CD8+ T-lymphocyte activation and differentiation in vivo. PLoS ONE. 2015;10:e0124246 pubmed publisher
Zaccard C, Watkins S, Kalinski P, Fecek R, Yates A, Salter R, et al. CD40L induces functional tunneling nanotube networks exclusively in dendritic cells programmed by mediators of type 1 immunity. J Immunol. 2015;194:1047-56 pubmed publisher
Nitschke K, Flecken T, Schmidt J, Gostick E, Marget M, Neumann Haefelin C, et al. Tetramer enrichment reveals the presence of phenotypically diverse hepatitis C virus-specific CD8+ T cells in chronic infection. J Virol. 2015;89:25-34 pubmed publisher
Perreau M, Vigano S, Bellanger F, Pellaton C, Buss G, Comte D, et al. Exhaustion of bacteria-specific CD4 T cells and microbial translocation in common variable immunodeficiency disorders. J Exp Med. 2014;211:2033-45 pubmed publisher
Hoyer S, Prommersberger S, Pfeiffer I, Schuler Thurner B, Schuler G, Dörrie J, et al. Concurrent interaction of DCs with CD4(+) and CD8(+) T cells improves secondary CTL expansion: It takes three to tango. Eur J Immunol. 2014;44:3543-59 pubmed publisher
Killig M, Friedrichs B, Meisig J, Gentilini C, Blüthgen N, Loddenkemper C, et al. Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation. Eur J Immunol. 2014;44:2822-34 pubmed publisher
Osuna C, Gonzalez A, Chang H, Hung A, Ehlinger E, Anasti K, et al. TCR affinity associated with functional differences between dominant and subdominant SIV epitope-specific CD8+ T cells in Mamu-A*01+ rhesus monkeys. PLoS Pathog. 2014;10:e1004069 pubmed publisher
Romano E, Michielin O, Voelter V, Laurent J, Bichat H, Stravodimou A, et al. MART-1 peptide vaccination plus IMP321 (LAG-3Ig fusion protein) in patients receiving autologous PBMCs after lymphodepletion: results of a Phase I trial. J Transl Med. 2014;12:97 pubmed publisher
Clay C, Donart N, Fomukong N, Knight J, Overheim K, Tipper J, et al. Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses. Immun Ageing. 2014;11:4 pubmed publisher
Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol. 2014;192:2634-42 pubmed publisher
Alejenef A, Pachnio A, Halawi M, Christmas S, Moss P, Khan N. Cytomegalovirus drives V?2neg ?? T cell inflation in many healthy virus carriers with increasing age. Clin Exp Immunol. 2014;176:418-28 pubmed publisher
Lehmann D, Spanholtz J, Sturtzel C, Tordoir M, Schlechta B, Groenewegen D, et al. IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential. PLoS ONE. 2014;9:e87131 pubmed publisher
Wong J, Muthuswamy R, Bartlett D, Kalinski P. IL-18-based combinatorial adjuvants promote the intranodal production of CCL19 by NK cells and dendritic cells of cancer patients. Oncoimmunology. 2013;2:e26245 pubmed
Pradier A, Tabone Eglinger S, Huber V, Bosshard C, Rigal E, Wehrle Haller B, et al. Peripheral blood CD56(bright) NK cells respond to stem cell factor and adhere to its membrane-bound form after upregulation of c-kit. Eur J Immunol. 2014;44:511-20 pubmed publisher
Lécuroux C, Saez Cirion A, Girault I, Versmisse P, Boufassa F, Avettand Fenoel V, et al. Both HLA-B*57 and plasma HIV RNA levels contribute to the HIV-specific CD8+ T cell response in HIV controllers. J Virol. 2014;88:176-87 pubmed publisher
Pritz T, Landgraf Rauf K, Herndler Brandstetter D, Rauf R, Lair J, Gassner R, et al. Bone marrow T cells from the femur are similar to iliac crest derived cells in old age and represent a useful tool for studying the aged immune system. Immun Ageing. 2013;10:17 pubmed publisher
Alonzo F, Kozhaya L, Rawlings S, Reyes Robles T, Dumont A, Myszka D, et al. CCR5 is a receptor for Staphylococcus aureus leukotoxin ED. Nature. 2013;493:51-5 pubmed publisher
Le Friec G, Sheppard D, Whiteman P, Karsten C, Shamoun S, Laing A, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity. Nat Immunol. 2012;13:1213-21 pubmed publisher
Sato W, Tomita A, Ichikawa D, Lin Y, Kishida H, Miyake S, et al. CCR2(+)CCR5(+) T cells produce matrix metalloproteinase-9 and osteopontin in the pathogenesis of multiple sclerosis. J Immunol. 2012;189:5057-65 pubmed publisher
Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, et al. Biomarkers on melanoma patient T cells associated with ipilimumab treatment. J Transl Med. 2012;10:146 pubmed publisher
Napoletano C, Zizzari I, Rughetti A, Rahimi H, Irimura T, Clausen H, et al. Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur J Immunol. 2012;42:936-45 pubmed publisher
Pandya A, Al Jaderi Z, Høglund R, Holmøy T, Harbo H, Norgauer J, et al. Identification of human NK17/NK1 cells. PLoS ONE. 2011;6:e26780 pubmed publisher
Barbosa R, Silva S, Silva S, Melo A, Pedro E, Barbosa M, et al. Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation. PLoS ONE. 2011;6:e22848 pubmed publisher
Bosco M, Pierobon D, Blengio F, Raggi F, Vanni C, Gattorno M, et al. Hypoxia modulates the gene expression profile of immunoregulatory receptors in human mature dendritic cells: identification of TREM-1 as a novel hypoxic marker in vitro and in vivo. Blood. 2011;117:2625-39 pubmed publisher
Zhang H, Song K, Rabin R, Hill B, Perfetto S, Roederer M, et al. CCR2 identifies a stable population of human effector memory CD4+ T cells equipped for rapid recall response. J Immunol. 2010;185:6646-63 pubmed publisher
Jones G, McLoughlin R, Hammond V, Parker C, Williams J, Malhotra R, et al. Loss of CD4+ T cell IL-6R expression during inflammation underlines a role for IL-6 trans signaling in the local maintenance of Th17 cells. J Immunol. 2010;184:2130-9 pubmed publisher
Kishuku M, Nishioka Y, Abe S, Kishi J, Ogino H, Aono Y, et al. Expression of soluble vascular endothelial growth factor receptor-1 in human monocyte-derived mature dendritic cells contributes to their antiangiogenic property. J Immunol. 2009;183:8176-85 pubmed publisher
Berrih Aknin S, Ruhlmann N, Bismuth J, Cizeron Clairac G, Zelman E, Shachar I, et al. CCL21 overexpressed on lymphatic vessels drives thymic hyperplasia in myasthenia. Ann Neurol. 2009;66:521-31 pubmed publisher
Pedersen A, Holmstrøm K, Jensen S, Fuchs D, Rasmussen S, Kvistborg P, et al. Phenotypic and functional markers for 1alpha,25-dihydroxyvitamin D(3)-modified regulatory dendritic cells. Clin Exp Immunol. 2009;157:48-59 pubmed publisher
Ehlin Henriksson B, Liang W, Cagigi A, Mowafi F, Klein G, Nilsson A. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology. 2009;127:549-57 pubmed publisher
Dulphy N, Haas P, Busson M, Belhadj S, Peffault De Latour R, Robin M, et al. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J Immunol. 2008;181:2227-37 pubmed
Tha In T, Metselaar H, Tilanus H, Groothuismink Z, Kuipers E, de Man R, et al. Intravenous immunoglobulins suppress T-cell priming by modulating the bidirectional interaction between dendritic cells and natural killer cells. Blood. 2007;110:3253-62 pubmed
Conrad C, Boyman O, Tonel G, Tun Kyi A, Laggner U, de Fougerolles A, et al. Alpha1beta1 integrin is crucial for accumulation of epidermal T cells and the development of psoriasis. Nat Med. 2007;13:836-42 pubmed
Fluur C, De Milito A, Fry T, Vivar N, Eidsmo L, Atlas A, et al. Potential role for IL-7 in Fas-mediated T cell apoptosis during HIV infection. J Immunol. 2007;178:5340-50 pubmed
Sen Y, Chunsong H, Baojun H, Linjie Z, Qun L, San J, et al. Aberration of CCR7 CD8 memory T cells from patients with systemic lupus erythematosus: an inducer of T helper type 2 bias of CD4 T cells. Immunology. 2004;112:274-89 pubmed
product information
brand :
R&D Systems
master code :
FAB197F
SKU :
FAB197F-025
product name :
Human CCR7 Fluorescein-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Human CCR7 Fluorescein-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to CCR7. This antibody reacts with human,primate - chlorocebus pygerythrus (vervet monkey),primate - macaca mulatta (rhesus macaque). The Human CCR7 Fluorescein-conjugated Antibody has been validated for the following applications: CAR-T (Flow Cytometry),Flow Cytometry,Immunocytochemistry.
target :
CCR7
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
150503
conjugate :
Fluorescein
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
Human CCR7 transfectants, Met1-Pro378, Accession # AAA58615
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Primate - Chlorocebus pygerythrus (Vervet Monkey),Primate - Macaca mulatta (Rhesus Macaque)
specificity :
Detects human CCR7.
gene symbol :
CCR7
top caption :
Detection of CCR7 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.
accessionNumbers :
AAA58615
applications :
CAR-T (Flow Cytometry),Flow Cytometry,Immunocytochemistry
extended description :
Clone 150503 was used by HLDA to establish CD designation
USD :
129 USD
product details :
Clone 150503 was used by HLDA to establish CD designation
alt names :
BLR2, BLR2C-C chemokine receptor type 7, C-C CKR-7, CC-CKR-7, CCR7, CCR-7, CD197, CD197 antigen, CDw197, CDw197CC chemokine receptor 7, chemokine (C-C motif) receptor 7, CMKBR7, CMKBR7chemokine (C-C) receptor 7, EBI1, EBI1EBV-induced G protein-coupled receptor 1, EBV-induced G-protein coupled receptor 1, Epstein-Barr virus induced gene 1, Epstein-Barr virus induced G-protein coupled receptor, Epstein-Barr virus-induced G-protein coupled receptor 1, EVI1, lymphocyte-specific G protein-coupled peptide receptor, MIP-3 beta receptor
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.