product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human CXCR5 PE-conjugated Antibody
catalog :
FAB190P-100
quantity :
100 Tests (also 25 Tests)
price :
449 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
51505
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, flow cytometry
more info or order :
R&D Systems product webpage
citations: 25
Reference
Bunse M, Pfeilschifter J, Bluhm J, Zschummel M, Joedicke J, Wirges A, et al. CXCR5 CAR-T cells simultaneously target B cell non-Hodgkin's lymphoma and tumor-supportive follicular T helper cells. Nat Commun. 2021;12:240 pubmed publisher
Cunill V, Clemente A, Lanio N, Barceló C, Andreu V, Pons J, et al. Follicular T Cells from smB- Common Variable Immunodeficiency Patients Are Skewed Toward a Th1 Phenotype. Front Immunol. 2017;8:174 pubmed publisher
Flint S, Gibson A, Lucas G, Nandigam R, Taylor L, Provan D, et al. A distinct plasmablast and naïve B-cell phenotype in primary immune thrombocytopenia. Haematologica. 2016;101:698-706 pubmed publisher
Carrega P, Loiacono F, Di Carlo E, Scaramuccia A, Mora M, Conte R, et al. NCR(+)ILC3 concentrate in human lung cancer and associate with intratumoral lymphoid structures. Nat Commun. 2015;6:8280 pubmed publisher
Kim S, Ryu K, Hong M, Ko Y, Kim W. The serum CXCL13 level is associated with the Glasgow Prognostic Score in extranodal NK/T-cell lymphoma patients. J Hematol Oncol. 2015;8:49 pubmed publisher
Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, et al. Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines. PLoS ONE. 2015;10:e0120069 pubmed publisher
Martinez Martin N, Viejo Borbolla A, Martín R, Blanco S, Benovic J, Thelen M, et al. Herpes simplex virus enhances chemokine function through modulation of receptor trafficking and oligomerization. Nat Commun. 2015;6:6163 pubmed publisher
Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol. 2014;192:2634-42 pubmed publisher
Lehmann D, Spanholtz J, Sturtzel C, Tordoir M, Schlechta B, Groenewegen D, et al. IL-12 directs further maturation of ex vivo differentiated NK cells with improved therapeutic potential. PLoS ONE. 2014;9:e87131 pubmed publisher
Badr G, Lefevre E, Mohany M. Thymoquinone inhibits the CXCL12-induced chemotaxis of multiple myeloma cells and increases their susceptibility to Fas-mediated apoptosis. PLoS ONE. 2011;6:e23741 pubmed publisher
Barbosa R, Silva S, Silva S, Melo A, Pedro E, Barbosa M, et al. Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation. PLoS ONE. 2011;6:e22848 pubmed publisher
Hosomi S, Oshitani N, Kamata N, Sogawa M, Okazaki H, Tanigawa T, et al. Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis. Clin Exp Immunol. 2011;163:215-24 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Ehlin Henriksson B, Liang W, Cagigi A, Mowafi F, Klein G, Nilsson A. Changes in chemokines and chemokine receptor expression on tonsillar B cells upon Epstein-Barr virus infection. Immunology. 2009;127:549-57 pubmed publisher
Panse J, Friedrichs K, Marx A, Hildebrandt Y, Luetkens T, Barrels K, et al. Chemokine CXCL13 is overexpressed in the tumour tissue and in the peripheral blood of breast cancer patients. Br J Cancer. 2008;99:930-8 pubmed publisher
Cagigi A, Mowafi F, Phuong Dang L, Tenner Racz K, Atlas A, Grutzmeier S, et al. Altered expression of the receptor-ligand pair CXCR5/CXCL13 in B cells during chronic HIV-1 infection. Blood. 2008;112:4401-10 pubmed publisher
Moir S, Ho J, Malaspina A, Wang W, DiPoto A, O Shea M, et al. Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals. J Exp Med. 2008;205:1797-805 pubmed publisher
Maru S, Holloway K, Flynn G, Lancashire C, Loughlin A, Male D, et al. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. J Neuroimmunol. 2008;199:35-45 pubmed publisher
Nonomura C, Kikuchi J, Kiyokawa N, Ozaki H, Mitsunaga K, Ando H, et al. CD43, but not P-selectin glycoprotein ligand-1, functions as an E-selectin counter-receptor in human pre-B-cell leukemia NALL-1. Cancer Res. 2008;68:790-9 pubmed publisher
Badr G, Borhis G, Lefevre E, Chaoul N, Deshayes F, Dessirier V, et al. BAFF enhances chemotaxis of primary human B cells: a particular synergy between BAFF and CXCL13 on memory B cells. Blood. 2008;111:2744-54 pubmed publisher
Bürkle A, Niedermeier M, Schmitt Gräff A, Wierda W, Keating M, Burger J. Overexpression of the CXCR5 chemokine receptor, and its ligand, CXCL13 in B-cell chronic lymphocytic leukemia. Blood. 2007;110:3316-25 pubmed
Ettinger R, Sims G, Robbins R, Withers D, Fischer R, Grammer A, et al. IL-21 and BAFF/BLyS synergize in stimulating plasma cell differentiation from a unique population of human splenic memory B cells. J Immunol. 2007;178:2872-82 pubmed
Muller A, Sonkoly E, Eulert C, Gerber P, Kubitza R, Schirlau K, et al. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int J Cancer. 2006;118:2147-57 pubmed
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, et al. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood. 2005;105:931-9 pubmed
Giunti D, Borsellino G, Benelli R, Marchese M, Capello E, Valle M, et al. Phenotypic and functional analysis of T cells homing into the CSF of subjects with inflammatory diseases of the CNS. J Leukoc Biol. 2003;73:584-90 pubmed
image
image 1 :
R&D Systems FAB190P-100 image 1
Detection of CXCR5 antibody in CD4+ Human PBMCs antibody by Flow Cytometry.
product information
master code :
FAB190P
SKU :
FAB190P-100
product name :
Human CXCR5 PE-conjugated Antibody
unit size :
100 Tests (also 25 Tests)
description :
The Human CXCR5 PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to CXCR5. This antibody reacts with human,xenograft. The Human CXCR5 PE-conjugated Antibody has been validated for the following applications: Immunohistochemistry,Flow Cytometry,Immunocytochemistry.
target :
CXCR5
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide. *Small pack size (SP) is supplied either lyophilized or as a 0.2 ╡m filtered solution in PBS.
clonality :
Monoclonal
clone :
51505
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
NS0 mouse myeloma cell line transfected with human CXCR5, Met1-Phe372, Accession # P32302
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Xenograft
specificity :
Stains human CXCR5 transfectants but not the parental cell lines in flow cytometry. Does not cross-react with human CXCR2, CXCR3, or CXCR4 transfectants.
gene symbol :
CXCR5
top caption :
Detection of CXCR5 antibody in CD4+ Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
P32302
applications :
Flow Cytometry,Immunohistochemistry,Immunocytochemistry
extended description :
Clone 51505 was used by HLDA to establish CD designation
USD :
449 USD
product details :
Clone 51505 was used by HLDA to establish CD designation
alt names :
BLR1, BLR1MDR-15, Burkitt lymphoma receptor 1, Burkitt lymphoma receptor 1, GTP binding protein (chemokine (C-X-C motif)receptor 5), Burkitt lymphoma receptor 1, GTP-binding protein, CD185, CD185 antigen, chemokine (C-X-C motif) receptor 5, C-X-C chemokine receptor type 5, CXCR5, CXC-R5, MDR15CXCR-5, MGC117347, Monocyte-derived receptor 15
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.