product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human KIR2DL1/KIR2DS5 PE-conjugated Antibody
catalog :
FAB1844P-025
quantity :
25 Tests (also 100 Tests)
price :
129 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
143211
reactivity :
human
application :
immunohistochemistry, flow cytometry, FACS
more info or order :
citations: 11
Reference
Lee S, Chae S, Jang I, Oh S, Kim S, Lee S, et al. B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies. EBioMedicine. 2024;110:105459 pubmed publisher
Ryan J, Haight C, Niemi E, Grab J, Dodge J, Lanier L, et al. Hepatocellular carcinoma after direct-acting antivirals for hepatitis C is associated with KIR-HLA types predicting weak NK cell-mediated immunity. Eur J Immunol. 2024;54:e2350678 pubmed publisher
Cichocki F, Bjordahl R, Goodridge J, Mahmood S, Gaidarova S, Abujarour R, et al. Quadruple gene-engineered natural killer cells enable multi-antigen targeting for durable antitumor activity against multiple myeloma. Nat Commun. 2022;13:7341 pubmed publisher
Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
Sim M, Rajagopalan S, Altmann D, Boyton R, Sun P, Long E. Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Kristensen A, Kent S, Parsons M. Contribution of NK Cell Education to both Direct and Anti-HIV-1 Antibody-Dependent NK Cell Functions. J Virol. 2018;92: pubmed publisher
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M. Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol. 2013;43:480-7 pubmed publisher
Markel G, Seidman R, Besser M, Zabari N, Ortenberg R, Shapira R, et al. Natural killer lysis receptor (NKLR)/NKLR-ligand matching as a novel approach for enhancing anti-tumor activity of allogeneic NK cells. PLoS ONE. 2009;4:e5597 pubmed publisher
Cai L, Zhang Z, Zhou L, Wang H, Fu J, Zhang S, et al. Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients. Clin Immunol. 2008;129:428-37 pubmed publisher
Binyamin L, Alpaugh R, Hughes T, Lutz C, Campbell K, Weiner L. Blocking NK cell inhibitory self-recognition promotes antibody-dependent cellular cytotoxicity in a model of anti-lymphoma therapy. J Immunol. 2008;180:6392-401 pubmed
Ballan W, Vu B, Long B, Loo C, Michaelsson J, Barbour J, et al. Natural killer cells in perinatally HIV-1-infected children exhibit less degranulation compared to HIV-1-exposed uninfected children and their expression of KIR2DL3, NKG2C, and NKp46 correlates with disease severity. J Immunol. 2007;179:3362-70 pubmed
product information
master code :
FAB1844P
SKU :
FAB1844P-025
product name :
Human KIR2DL1/KIR2DS5 PE-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
description :
The Human KIR2DL1/KIR2DS5 PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to KIR2DL1/KIR2DS5. This antibody reacts with human. The Human KIR2DL1/KIR2DS5 PE-conjugated Antibody has been validated for the following applications: FACS,Flow Cytometry,Immunohistochemistry.
target :
KIR2DL1/KIR2DS5
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
143211
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human KIR2DL1/KIR2DS5, Accession # P43626
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human KIR2DL1/KIR2DS5 on transfected cells. It does not stain cells transfected with KIR2DL2, 2DL3, 2DL4, 2DL5, 2DS1, 2DS2, 2DS4, 3DL1, 3DL2, or 3DS1.
gene symbol :
KIR2DL1
top caption :
Detection of KIR2DL1/KIR2DS5 antibody in Human PBMCs antibody by Flow Cytometry.
accessionNumbers :
P43626
applications :
FACS,Flow Cytometry,Immunohistochemistry
USD :
129 USD
alt names :
CD158a, CD158g, NKAT9
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.