product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human/Mouse TREM2 APC-conjugated Antibody
catalog :
FAB17291A
quantity :
100 Tests
price :
499 USD
clonality :
monoclonal
host :
rat
conjugate :
APC
clone name :
237920
reactivity :
human, mouse
application :
neutralization, flow cytometry
more info or order :
R&D Systems product webpage
citations: 24
Reference
Deng M, Odhiambo W, Qin M, To T, Brewer G, Kheshvadjian A, et al. Analysis of Intracellular Communication Reveals Consistent Gene Changes Associated with Early-Stage Acne Skin. Res Sq. 2024;: pubmed publisher
Sun R, Lei C, Xu Z, Gu X, Huang L, Chen L, et al. Neutral ceramidase regulates breast cancer progression by metabolic programming of TREM2-associated macrophages. Nat Commun. 2024;15:966 pubmed publisher
Gao H, Di J, Clausen B, Wang N, Zhu X, Zhao T, et al. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders. Cell Rep. 2023;42:112629 pubmed publisher
Wang R, Li H, Ling C, Zhang X, Lu J, Luan W, et al. A novel phenotype of B cells associated with enhanced phagocytic capability and chemotactic function after ischemic stroke. Neural Regen Res. 2023;18:2413-2423 pubmed publisher
Haensel D, Dániel B, Gaddam S, Pan C, Fabo T, Bjelajac J, et al. Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche. Nat Commun. 2023;14:2685 pubmed publisher
Dayananda K, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Early life stress impairs synaptic pruning in the developing hippocampus. Brain Behav Immun. 2023;107:16-31 pubmed publisher
He W, Huang C, Wang L, Su W, Wang S, Huang P, et al. The correlation between triiodothyronine and the severity of liver fibrosis. BMC Endocr Disord. 2022;22:313 pubmed publisher
Lu Y, Yang A, Quan C, Pan Y, Zhang H, Li Y, et al. A single-cell atlas of the multicellular ecosystem of primary and metastatic hepatocellular carcinoma. Nat Commun. 2022;13:4594 pubmed publisher
Jung S, Hwang B, Shin S, Park E, Park S, Kim C, et al. Spatiotemporal dynamics of macrophage heterogeneity and a potential function of Trem2hi macrophages in infarcted hearts. Nat Commun. 2022;13:4580 pubmed publisher
Dabla A, Liang Y, Rajabalee N, Irwin C, Moonen C, Willis J, et al. TREM2 Promotes Immune Evasion by Mycobacterium tuberculosis in Human Macrophages. MBio. 2022;13:e0145622 pubmed publisher
Do T, Ma F, Andrade P, Teles R, de Andrade Silva B, Hu C, et al. TREM2 macrophages induced by human lipids drive inflammation in acne lesions. Sci Immunol. 2022;7:eabo2787 pubmed publisher
Connor S, Rashid M, Ryan K, Patel K, Boyd J, Smith J, et al. GW5074 Increases Microglial Phagocytic Activities: Potential Therapeutic Direction for Alzheimer's Disease. Front Cell Neurosci. 2022;16:894601 pubmed publisher
Willenborg S, Roscito J, Gerbaulet A, Roers A, Dahl A, Eming S, et al. Isolation of macrophages from mouse skin wounds for single-cell RNA sequencing. STAR Protoc. 2022;3:101337 pubmed publisher
Combes A, Samad B, TSUI J, Chew N, Yan P, Reeder G, et al. Discovering dominant tumor immune archetypes in a pan-cancer census. Cell. 2022;185:184-203.e19 pubmed publisher
Binnewies M, Pollack J, Rudolph J, Dash S, Abushawish M, Lee T, et al. Targeting TREM2 on tumor-associated macrophages enhances immunotherapy. Cell Rep. 2021;37:109844 pubmed publisher
Sek A, Percopo C, Boddapati A, Ma M, Geslewitz W, Krumholz J, et al. Differential expression of Triggering Receptor Expressed on Myeloid cells 2 (Trem2) in tissue eosinophils. J Leukoc Biol. 2021;110:679-691 pubmed publisher
Kluckova K, Kozak J, Szaboova K, Rychly B, Svajdler M, Suchánková M, et al. TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients. Mediators Inflamm. 2020;2020:1798147 pubmed publisher
Vijayan M, Lee C, Wong V, Wang X, Bai K, Wu J, et al. Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. J Cell Sci. 2020;133: pubmed publisher
Suchánková M, Urban J, Ganovska M, Tibenska E, Szaboova K, Tedlova E, et al. TREM-1 and TREM-2 Expression on CD14+ Cells in Bronchoalveolar Lavage Fluid in Pulmonary Sarcoidosis and Hypersensitivity Pneumonitis in the Context of T Cell Immune Response. Mediators Inflamm. 2020;2020:9501617 pubmed publisher
Grubman A, Vandekolk T, Schröder J, Sun G, Hatwell Humble J, Chan J, et al. A CX3CR1 Reporter hESC Line Facilitates Integrative Analysis of In-Vitro-Derived Microglia and Improved Microglia Identity upon Neuron-Glia Co-culture. Stem Cell Reports. 2020;14:1018-1032 pubmed publisher
Binnewies M, Mujal A, Pollack J, Combes A, Hardison E, Barry K, et al. Unleashing Type-2 Dendritic Cells to Drive Protective Antitumor CD4+ T Cell Immunity. Cell. 2019;177:556-571.e16 pubmed publisher
Cheng Q, Danao J, Talreja S, Wen P, Yin J, Sun N, et al. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function. J Biol Chem. 2018;293:12620-12633 pubmed publisher
Hall S, Agrawal D. Increased TREM-2 expression on the subsets of CD11c+ cells in the lungs and lymph nodes during allergic airway inflammation. Sci Rep. 2017;7:11853 pubmed publisher
Chan G, White C, Winn P, Cimpean M, Replogle J, Glick L, et al. CD33 modulates TREM2: convergence of Alzheimer loci. Nat Neurosci. 2015;18:1556-8 pubmed publisher
product information
master code :
FAB17291A
SKU :
FAB17291A
product name :
Human/Mouse TREM2 APC-conjugated Antibody
unit size :
100 Tests
description :
The Human/Mouse TREM2 APC-conjugated Antibody from R&D Systems is a rat monoclonal antibody to TREM2. This antibody reacts with human,mouse. The Human/Mouse TREM2 APC-conjugated Antibody has been validated for the following applications: Flow Cytometry,Neutralization.
target :
TREM2
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
237920
conjugate :
Allophycocyanin
host :
Rat
immunogen :
Mouse myeloma cell line NS0-derived recombinant mouse TREM-2, extracellular domain, Accession # Q99NH8
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Mouse
specificity :
Detects human and mouse TREM-2 in direct ELISAs and Western blots. Stains TREM-2 transfectants but not TREM-1 transfectants.
gene symbol :
TREM2
top caption :
Detection of TREM-2 antibody in RAW 264.7 Mouse Cell Line antibody by Flow Cytometry.
accessionNumbers :
Q99NH8
applications :
Flow Cytometry,Neutralization
USD :
499 USD
alt names :
PLOSL2, TREM-2, Trem2a, Trem2b, Trem2c, TREM-2triggering receptor expressed on myeloid cells 2a, Triggering receptor expressed on monocytes 2, triggering receptor expressed on myeloid cells 2
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.