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company name :
R&D Systems
product type :
antibody
product name :
Human CXCR4 PE-conjugated Antibody
catalog :
FAB170P-025
quantity :
25 Tests (also 100 Tests)
price :
169 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
12G5
reactivity :
human, mouse
application :
immunocytochemistry, flow cytometry
more info or order :
citations: 40
Reference
Garc xed a Cuesta E, Mart xed nez P, Selvaraju K, Ulltj xe4 rn G, G xf3 mez Pozo A, D Agostino G, et al. Allosteric modulation of the CXCR4:CXCL12 axis by targeting receptor nanoclustering via the TMV-TMVI domain. elife. 2024;13: pubmed publisher
Portella L, Bertolini G, Guardascione G, Di Febbraro D, Ieran xf2 C, D Alterio C, et al. CXCL12-loaded-hydrogel (CLG): A new device for metastatic circulating tumor cells (CTCs) capturing and characterization. Heliyon. 2024;10:e35524 pubmed publisher
Trotta A, Tomassi S, Di Maiolo G, Ieran xf2 C, Vetrei C, D Alterio C, et al. Disulfide bond replacement with non-reducible side chain to tail macrolactamization for the development of potent and selective CXCR4 peptide antagonists endowed with flanking binding sites. Eur J Med Chem. 2024;276:116669 pubmed publisher
Garrido Trigo A, Corraliza A, Veny M, Dotti I, Mel xf3 n Ardanaz E, Rill A, et al. Macrophage and neutrophil heterogeneity at single-cell spatial resolution in human inflammatory bowel disease. Nat Commun. 2023;14:4506 pubmed publisher
Veschi V, Turdo A, Modica C, Verona F, Di Franco S, Gaggianesi M, et al. Recapitulating thyroid cancer histotypes through engineering embryonic stem cells. Nat Commun. 2023;14:1351 pubmed publisher
Paradis J, Feng X, Murat B, Jefferson R, Sokrat B, Szpakowska M, et al. Computationally designed GPCR quaternary structures bias signaling pathway activation. Nat Commun. 2022;13:6826 pubmed publisher
Bona A, Seifert M, Th xfc nauer R, Zodel K, Frew I, R xf6 mer W, et al. MARVEL domain containing CMTM4 affects CXCR4 trafficking. Mol Biol Cell. 2022;33:ar116 pubmed publisher
Lee Theilen M, Hadhoud J, Volante G, Fadini D, Eichhorn J, Rolle U, et al. Co-Expression of CD34, CD90, OV-6 and Cell-Surface Vimentin Defines Cancer Stem Cells of Hepatoblastoma, Which Are Affected by Hsp90 Inhibitor 17-AAG. Cells. 2021;10: pubmed publisher
Kowal J, M xf6 ller S, Ali D, Figeac F, Barington T, Schmal H, et al. Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells. Stem Cell Res Ther. 2021;12:265 pubmed publisher
Lagrée A, Fasani F, Rouxel C, Pivet M, Pourcelot M, Fablet A, et al. Bovine Organospecific Microvascular Endothelial Cell Lines as New and Relevant In Vitro Models to Study Viral Infections. Int J Mol Sci. 2020;21: pubmed publisher
Leibel S, McVicar R, Winquist A, Niles W, Snyder E. Generation of Complete Multi-Cell Type Lung Organoids From Human Embryonic and Patient-Specific Induced Pluripotent Stem Cells for Infectious Disease Modeling and Therapeutics Validation. Curr Protoc Stem Cell Biol. 2020;54:e118 pubmed publisher
Tan S, Li W, Li Z, Li Y, Luo J, Yu L, et al. A Novel CXCR4 Targeting Protein SDF-1/54 as an HIV-1 Entry Inhibitor. Viruses. 2019;11: pubmed publisher
Del Molino Del Barrio I, Wilkins G, Meeson A, Ali S, Kirby J. Breast Cancer: An Examination of the Potential of ACKR3 to Modify the Response of CXCR4 to CXCL12. Int J Mol Sci. 2018;19: pubmed publisher
Andersen P, Tampakakis E, Jimenez D, Kannan S, Miyamoto M, Shin H, et al. Precardiac organoids form two heart fields via Bmp/Wnt signaling. Nat Commun. 2018;9:3140 pubmed publisher
Aversa I, Zolea F, Ieranò C, Bulotta S, Trotta A, Faniello M, et al. Epithelial-to-mesenchymal transition in FHC-silenced cells: the role of CXCR4/CXCL12 axis. J Exp Clin Cancer Res. 2017;36:104 pubmed publisher
Cheng T, Zhai K, Chang Y, Yao G, He J, Wang F, et al. CHIR99021 combined with retinoic acid promotes the differentiation of primordial germ cells from human embryonic stem cells. Oncotarget. 2017;8:7814-7826 pubmed publisher
Monsuur H, Weijers E, Niessen F, Gefen A, Koolwijk P, Gibbs S, et al. Extensive Characterization and Comparison of Endothelial Cells Derived from Dermis and Adipose Tissue: Potential Use in Tissue Engineering. PLoS ONE. 2016;11:e0167056 pubmed publisher
Vincenzi M, Costantini S, Scala S, Tesauro D, Accardo A, Leone M, et al. Conformational ensembles explored dynamically from disordered peptides targeting chemokine receptor CXCR4. Int J Mol Sci. 2015;16:12159-73 pubmed publisher
Yu J, Ramasamy T, Murphy N, Holt M, Czapiewski R, Wei S, et al. PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation. Nat Commun. 2015;6:7212 pubmed publisher
Panneerselvam J, Jin J, Shanker M, Lauderdale J, BATES J, Wang Q, et al. IL-24 inhibits lung cancer cell migration and invasion by disrupting the SDF-1/CXCR4 signaling axis. PLoS ONE. 2015;10:e0122439 pubmed publisher
Shankar V, Hori H, Kihira K, Lei Q, Toyoda H, Iwamoto S, et al. Mesenchymal stromal cell secretome up-regulates 47 kDa CXCR4 expression, and induce invasiveness in neuroblastoma cell lines. PLoS ONE. 2015;10:e0120069 pubmed publisher
Perrigue P, Silva M, Warden C, Feng N, Reid M, Mota D, et al. The histone demethylase jumonji coordinates cellular senescence including secretion of neural stem cell-attracting cytokines. Mol Cancer Res. 2015;13:636-50 pubmed publisher
Peled A, Abraham M, Avivi I, Rowe J, Beider K, Wald H, et al. The high-affinity CXCR4 antagonist BKT140 is safe and induces a robust mobilization of human CD34+ cells in patients with multiple myeloma. Clin Cancer Res. 2014;20:469-79 pubmed publisher
Portella L, Vitale R, De Luca S, D Alterio C, Ierano C, Napolitano M, et al. Preclinical development of a novel class of CXCR4 antagonist impairing solid tumors growth and metastases. PLoS ONE. 2013;8:e74548 pubmed publisher
Goldman O, Han S, Sourisseau M, Sourrisseau M, Dziedzic N, Hamou W, et al. KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development. Cell Stem Cell. 2013;12:748-60 pubmed publisher
Cerdeira A, Rajakumar A, Royle C, Lo A, Husain Z, THADHANI R, et al. Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors. J Immunol. 2013;190:3939-48 pubmed publisher
Shantsila E, Tapp L, Wrigley B, Montoro García S, Lip G. CXCR4 positive and angiogenic monocytes in myocardial infarction. Thromb Haemost. 2013;109:255-62 pubmed publisher
Bone H, Nelson A, Goldring C, Tosh D, Welham M. A novel chemically directed route for the generation of definitive endoderm from human embryonic stem cells based on inhibition of GSK-3. J Cell Sci. 2011;124:1992-2000 pubmed publisher
Shantsila E, Wrigley B, Tapp L, Apostolakis S, Montoro Garcia S, Drayson M, et al. Immunophenotypic characterization of human monocyte subsets: possible implications for cardiovascular disease pathophysiology. J Thromb Haemost. 2011;9:1056-66 pubmed publisher
Cronin P, Wang J, Redmond H. Hypoxia increases the metastatic ability of breast cancer cells via upregulation of CXCR4. BMC Cancer. 2010;10:225 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Levings P, McGarry S, Currie T, Nickerson D, McClellan S, Ghivizzani S, et al. Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res. 2009;69:5648-55 pubmed publisher
Kroeze K, Jurgens W, Doulabi B, van Milligen F, Scheper R, Gibbs S. Chemokine-mediated migration of skin-derived stem cells: predominant role for CCL5/RANTES. J Invest Dermatol. 2009;129:1569-81 pubmed publisher
Bucay N, Yebra M, Cirulli V, Afrikanova I, Kaido T, Hayek A, et al. A novel approach for the derivation of putative primordial germ cells and sertoli cells from human embryonic stem cells. Stem Cells. 2009;27:68-77 pubmed publisher
Maru S, Holloway K, Flynn G, Lancashire C, Loughlin A, Male D, et al. Chemokine production and chemokine receptor expression by human glioma cells: role of CXCL10 in tumour cell proliferation. J Neuroimmunol. 2008;199:35-45 pubmed publisher
Misao Y, Takemura G, Arai M, Ohno T, Onogi H, Takahashi T, et al. Importance of recruitment of bone marrow-derived CXCR4+ cells in post-infarct cardiac repair mediated by G-CSF. Cardiovasc Res. 2006;71:455-65 pubmed
Muller A, Sonkoly E, Eulert C, Gerber P, Kubitza R, Schirlau K, et al. Chemokine receptors in head and neck cancer: association with metastatic spread and regulation during chemotherapy. Int J Cancer. 2006;118:2147-57 pubmed
Singh S, Singh U, Grizzle W, Lillard J. CXCL12-CXCR4 interactions modulate prostate cancer cell migration, metalloproteinase expression and invasion. Lab Invest. 2004;84:1666-76 pubmed
Piovan E, Tosello V, Indraccolo S, Cabrelle A, Baesso I, Trentin L, et al. Chemokine receptor expression in EBV-associated lymphoproliferation in hu/SCID mice: implications for CXCL12/CXCR4 axis in lymphoma generation. Blood. 2005;105:931-9 pubmed
Liu L, Jarjour N, Busse W, Kelly E. Chemokine receptor expression on human eosinophils from peripheral blood and bronchoalveolar lavage fluid after segmental antigen challenge. J Allergy Clin Immunol. 2003;112:556-62 pubmed
product information
brand :
R&D Systems
master code :
FAB170P
SKU :
FAB170P-025
product name :
Human CXCR4 PE-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Human CXCR4 PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to CXCR4. This antibody reacts with human,mouse,rabbit. The Human CXCR4 PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,Immunocytochemistry.
target :
CXCR4
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
12G5
conjugate :
Phycoerythrin
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line, Accession # P61073
isotype :
IgG2a
purity :
Protein A or G purified from ascites
species :
Human,Mouse,Rabbit
specificity :
Detects human CXCR4.
gene symbol :
CXCR4
top caption :
Detection of CXCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.
accessionNumbers :
P61073
applications :
Flow Cytometry,Immunocytochemistry
USD :
169 USD
alt names :
CD184, chemokine (C-X-C motif) receptor 4, chemokine (C-X-C motif), receptor 4 (fusin), C-X-C chemokine receptor type 4, CXC-R4, CXCR-4, D2S201E, D2S201ESDF-1 receptor, FB22, Fusin, HM89, HM89NPYRL, HSY3RR, LAP3, LAP-3, LCR1, LESTR, LESTRCD184 antigen, Leukocyte-derived seven transmembrane domain receptor, leukocyte-derived seven-transmembrane-domain receptor, lipopolysaccharide-associated protein 3, neuropeptide Y receptor Y3, NPY3R, NPY3RWHIM, NPYR, NPYRL, NPYY3R, pCXCR4, seven transmembrane helix receptor, seven-transmembrane-segment receptor, spleen, Stromal cell-derived factor 1 receptor, WHIMS
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.