product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human MICB APC-conjugated Antibody
catalog :
FAB1599A-025
quantity :
25 Tests (also 100 Tests)
price :
179 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
236511
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 17
Reference
Zhao N, Pi R, Nguyen D, Ranganath T, Seiler C, Holmes S, et al. NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells. bioRxiv. 2024;: pubmed publisher
Tsai C, Yang P, Hsu F, Cheng A, Yu W, Cheng J. Topoisomerase I Inhibition Radiosensitizing Hepatocellular Carcinoma by RNF144A-mediated DNA-PKcs Ubiquitination and Natural Killer Cell Cytotoxicity. J Clin Transl Hepatol. 2023;11:614-625 pubmed publisher
Calabrese D, Tsao T, Magnen M, Valet C, Gao Y, Mallavia B, et al. NKG2D receptor activation drives primary graft dysfunction severity and poor lung transplantation outcomes. JCI Insight. 2022;7: pubmed publisher
Lawrence M, Shahsavari A, Bornel xf6 v S, Moreau T, McDonald R, Vallance T, et al. Mapping the biogenesis of forward programmed megakaryocytes from induced pluripotent stem cells. Sci Adv. 2022;8:eabj8618 pubmed publisher
Petillo S, Capuano C, Molfetta R, Fionda C, Mekhloufi A, Pighi C, et al. Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition. Cell Death Dis. 2021;12:836 pubmed publisher
Jeon J, Baek I, Hong C, Park K, Lee H, Oh E, et al. Establishment of HLA class I and MICA/B null HEK-293T panel expressing single MICA alleles to detect anti-MICA antibodies. Sci Rep. 2021;11:15716 pubmed publisher
Björklund A, Carlsten M, Sohlberg E, Liu L, Clancy T, Karimi M, et al. Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. Clin Cancer Res. 2018;24:1834-1844 pubmed publisher
Fan X, Wang P, Zhang C, Zhang Y, Fu Y, Zhang C, et al. All-trans retinoic acid enhances cytotoxicity of CIK cells against human lung adenocarcinoma by upregulating MICA and IL-2 secretion. Sci Rep. 2017;7:16481 pubmed publisher
Niu C, Jin H, Li M, Zhu S, Zhou L, Jin F, et al. Low-dose bortezomib increases the expression of NKG2D and DNAM-1 ligands and enhances induced NK and γδ T cell-mediated lysis in multiple myeloma. Oncotarget. 2017;8:5954-5964 pubmed publisher
Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015;64:599-608 pubmed publisher
Gómez Lomelí P, Bravo Cuellar A, Hernández Flores G, Jave Suárez L, Aguilar Lemarroy A, Lerma Díaz J, et al. Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor. Cancer Cell Int. 2014;14:100 pubmed publisher
Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR? activation. J Exp Med. 2013;210:2675-92 pubmed publisher
Jardine L, Hambleton S, Bigley V, Pagan S, Wang X, Collin M. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leuk Lymphoma. 2013;54:167-73 pubmed publisher
MADRID A, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012;86:8693-704 pubmed publisher
Okita R, Mougiakakos D, Ando T, Mao Y, Sarhan D, Wennerberg E, et al. HER2/HER3 signaling regulates NK cell-mediated cytotoxicity via MHC class I chain-related molecule A and B expression in human breast cancer cell lines. J Immunol. 2012;188:2136-45 pubmed publisher
Del Toro Arreola S, Arreygue Garcia N, Aguilar Lemarroy A, Cid Arregui A, Jimenez Perez M, Haramati J, et al. MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines. Cancer Cell Int. 2011;11:15 pubmed publisher
Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, et al. Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC. Int J Cancer. 2009;125:212-21 pubmed publisher
product information
brand :
R&D Systems
master code :
FAB1599A
SKU :
FAB1599A-025
product name :
Human MICB APC-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Human MICB APC-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to MICB. This antibody reacts with human. The Human MICB APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
MICB
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
236511
conjugate :
Allophycocyanin
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
Mouse myeloma cell line NS0-derived recombinant human MICB, Ala23-Gly298, Accession # CAI18747
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human MICB in direct ELISAs and Western blots. Does not cross-react with recombinant human MICA.
gene symbol :
MICB
top caption :
Detection of MICB antibody in K562 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
CAI18747
applications :
Flow Cytometry
USD :
179 USD
alt names :
MHC class I chain-related protein B, MHC class I mic-B antigen, MHC class I polypeptide-related sequence B, MIC-B, PERB11.2MHC class I-like molecule PERB11.2-IMX, stress inducible class I homolog
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.