product summary
Loading...
company name :
R&D Systems
product type :
antibody
product name :
Human/Rat CCR4 Fluorescein-conjugated Antibody
catalog :
FAB1567F-025
quantity :
25 Tests (also 100 Tests)
price :
149 USD
clonality :
monoclonal
host :
mouse
conjugate :
FITC
clone name :
205410
reactivity :
human, rat
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 14
Reference
Wang Z, Ma J, Zhang H, Ramakrishna R, Mintzlaff D, Mathes D, et al. CCR4-IL2 bispecific immunotoxin is more effective than brentuximab for targeted therapy of cutaneous T-cell lymphoma in a mouse CTCL model. FEBS Open Bio. 2023;13:1309-1319 pubmed publisher
Amniai L, Ple C, Barrier M, de Nadai P, Marquillies P, Vorng H, et al. Natural Killer Cells from Allergic Donors Are Defective in Their Response to CCL18 Chemokine. Int J Mol Sci. 2021;22: pubmed publisher
Wang H, Wang Z, Zhang H, Qi Z, Johnson A, Mathes D, et al. Bispecific human IL2-CCR4 immunotoxin targets human cutaneous T-cell lymphoma. Mol Oncol. 2020;14:991-1000 pubmed publisher
Kitadate A, Ikeda S, Abe F, Takahashi N, Shimizu N, Matsue K, et al. Histone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas. Haematologica. 2018;103:126-135 pubmed publisher
Wang Z, Navarro Alvarez N, Shah J, Zhang H, Huang Q, Zheng Q, et al. Porcine Treg depletion with a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Vet Immunol Immunopathol. 2016;182:150-158 pubmed publisher
Maghazachi A, Sand K, Al Jaderi Z. Glatiramer Acetate, Dimethyl Fumarate, and Monomethyl Fumarate Upregulate the Expression of CCR10 on the Surface of Natural Killer Cells and Enhance Their Chemotaxis and Cytotoxicity. Front Immunol. 2016;7:437 pubmed
James E, Gates T, LaFond R, Yamamoto S, Ni C, Mai D, et al. Neuroinvasive West Nile Infection Elicits Elevated and Atypically Polarized T Cell Responses That Promote a Pathogenic Outcome. PLoS Pathog. 2016;12:e1005375 pubmed publisher
Wang Z, Pratts S, Zhang H, Spencer P, Yu R, Tonsho M, et al. Treg depletion in non-human primates using a novel diphtheria toxin-based anti-human CCR4 immunotoxin. Mol Oncol. 2016;10:553-65 pubmed publisher
Pandya A, Al Jaderi Z, Høglund R, Holmøy T, Harbo H, Norgauer J, et al. Identification of human NK17/NK1 cells. PLoS ONE. 2011;6:e26780 pubmed publisher
Oo Y, Weston C, Lalor P, Curbishley S, Withers D, Reynolds G, et al. Distinct roles for CCR4 and CXCR3 in the recruitment and positioning of regulatory T cells in the inflamed human liver. J Immunol. 2010;184:2886-98 pubmed publisher
Brucklacher Waldert V, Steinbach K, Lioznov M, Kolster M, Holscher C, Tolosa E. Phenotypical characterization of human Th17 cells unambiguously identified by surface IL-17A expression. J Immunol. 2009;183:5494-501 pubmed publisher
Finney O, Nwakanma D, Conway D, Walther M, Riley E. Homeostatic regulation of T effector to Treg ratios in an area of seasonal malaria transmission. Eur J Immunol. 2009;39:1288-300 pubmed publisher
Baatar D, Olkhanud P, Newton D, Sumitomo K, Biragyn A. CCR4-expressing T cell tumors can be specifically controlled via delivery of toxins to chemokine receptors. J Immunol. 2007;179:1996-2004 pubmed
Garcia G, Humbert M, Capel F, Rimaniol A, Escourrou P, Emilie D, et al. Chemokine receptor expression on allergen-specific T cells in asthma and allergic bronchopulmonary aspergillosis. Allergy. 2007;62:170-7 pubmed
product information
brand :
R&D Systems
master code :
FAB1567F
SKU :
FAB1567F-025
product name :
Human/Rat CCR4 Fluorescein-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Human/Rat CCR4 Fluorescein-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to CCR4. This antibody reacts with human,porcine,rat. The Human/Rat CCR4 Fluorescein-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
CCR4
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
205410
conjugate :
Fluorescein
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
Human CCR4 transfectants, Met1-Leu360, Accession # P51679
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human,Porcine,Rat
specificity :
Stains human CCR4-transfected cell lines but not the corresponding parent cell lines. Also detects human CCR4 on human PBLs and platelets and rat CCR4 on rat splenocytes.
gene symbol :
CCR4
top caption :
Detection of CCR4 antibody in Human Blood Lymphocytes antibody by Flow Cytometry.
accessionNumbers :
P51679
applications :
Flow Cytometry
extended description :
Clone 205410 was used by HLDA to establish CD designation
USD :
149 USD
product details :
Clone 205410 was used by HLDA to establish CD designation
alt names :
C-C chemokine receptor type 4, C-C CKR-4, CC-CKR-4HGCN:14099, CCR-4, CD194, CD194 antigen, chemokine (C-C motif) receptor 4, chemokine (C-C) receptor 4, ChemR13, CKR4MGC88293, CMKBR4k5-5, K5-5
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.