Human IL-27 R alpha /WSX-1/TCCR PE-conjugated Antibody | R&D Systems FAB14791P-100 product information

product summary

company name :

R&D Systems

product type :

antibody

product name :

Human IL-27 R alpha /WSX-1/TCCR PE-conjugated Antibody

catalog :

FAB14791P-100

quantity :

100 Tests (also 25 Tests)

price :

419 USD

clonality :

monoclonal

host :

mouse

conjugate :

clone name :

191106

reactivity :

human

application :

flow cytometry

more info or order :

R&D Systems product webpage

citations: 17

Reference
Martin E, Winter S, Garcin C, Tanita K, Hoshino A, Lenoir C, et al. Role of IL-27 in Epstein-Barr virus infection revealed by IL-27RA deficiency. Nature. 2024;628:620-629 pubmed publisher
Zhang Y, Wei S, Wu Q, Shen X, Dai W, Zhang Z, et al. Interleukin-35 promotes Breg expansion and interleukin-10 production in CD19+ B cells in patients with ankylosing spondylitis. Clin Rheumatol. 2022;41:2403-2416 pubmed publisher
Cheng J, Myers T, Levinger C, Kumar P, Kumar J, Goshu B, et al. IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells. iScience. 2022;25:103588 pubmed publisher
Khanam A, Ayithan N, Tang L, Poonia B, Kottilil S. IL-21-Deficient T Follicular Helper Cells Support B Cell Responses Through IL-27 in Patients With Chronic Hepatitis B. Front Immunol. 2020;11:599648 pubmed publisher
Cav xe9 M, Maillard S, Hildenbrand K, Mamelonet C, Feige M, Devergne O. Glycosaminoglycans bind human IL-27 and regulate its activity. Eur J Immunol. 2020;50:1484-1499 pubmed publisher
Goovaerts O, Massinga Loembe M, Ondoa P, Ceulemans A, Worodria W, Mayanja Kizza H, et al. Increased KLRG1 and PD-1 expression on CD8 T lymphocytes in TB-IRIS. PLoS ONE. 2019;14:e0215991 pubmed publisher
Rolvering C, Zimmer A, Ginolhac A, Margue C, Kirchmeyer M, Servais F, et al. The PD-L1- and IL6-mediated dampening of the IL27/STAT1 anticancer responses are prevented by α-PD-L1 or α-IL6 antibodies. J Leukoc Biol. 2018;104:969-985 pubmed publisher
Xu F, Yi J, Wang Z, Hu Y, Han C, Xue Q, et al. IL-27 regulates the adherence, proliferation, and migration of MSCs and enhances their regulatory effects on Th1 and Th2 subset generations. Immunol Res. 2017;65:903-912 pubmed publisher
Vijayan D, Mohd Redzwan N, Avery D, Wirasinha R, Brink R, Walters G, et al. IL-27 Directly Enhances Germinal Center B Cell Activity and Potentiates Lupus in Sanroque Mice. J Immunol. 2016;197:3008-3017 pubmed
Dietrich C, Candon S, Ruemmele F, Devergne O. A soluble form of IL-27R? is a natural IL-27 antagonist. J Immunol. 2014;192:5382-9 pubmed publisher
Morandi F, Airoldi I, Pistoia V. IL-27 driven upregulation of surface HLA-E expression on monocytes inhibits IFN-? release by autologous NK cells. J Immunol Res. 2014;2014:938561 pubmed publisher
Morandi F, Di Carlo E, Ferrone S, Petretto A, Pistoia V, Airoldi I. IL-27 in human secondary lymphoid organs attracts myeloid dendritic cells and impairs HLA class I-restricted antigen presentation. J Immunol. 2014;192:2634-42 pubmed publisher
Tzeng T, Tsay H, Chang L, Hsu C, Lai T, Huang F, et al. Caspase 3 involves in neuroplasticity, microglial activation and neurogenesis in the mice hippocampus after intracerebral injection of kainic acid. J Biomed Sci. 2013;20:90 pubmed publisher
Kachroo P, Lee M, Zhang L, Baratelli F, Lee G, Srivastava M, et al. IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer. J Exp Clin Cancer Res. 2013;32:97 pubmed publisher
Chen Q, Swaminathan S, Yang D, Dai L, Sui H, Yang J, et al. Interleukin-27 is a potent inhibitor of cis HIV-1 replication in monocyte-derived dendritic cells via a type I interferon-independent pathway. PLoS ONE. 2013;8:e59194 pubmed publisher
Guzzo C, Hopman W, Che Mat N, Wobeser W, Gee K. IL-27-induced gene expression is downregulated in HIV-infected subjects. PLoS ONE. 2012;7:e45706 pubmed publisher
Cocco C, Di Carlo E, Zupo S, Canale S, Zorzoli A, Ribatti D, et al. Complementary IL-23 and IL-27 anti-tumor activities cause strong inhibition of human follicular and diffuse large B-cell lymphoma growth in vivo. Leukemia. 2012;26:1365-74 pubmed publisher

product information

master code :

FAB14791P

SKU :

FAB14791P-100

product name :

Human IL-27 R alpha /WSX-1/TCCR PE-conjugated Antibody

unit size :

100 Tests (also 25 Tests)

description :

The Human IL-27 R alpha /WSX-1/TCCR PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to IL-27R alpha/WSX-1/TCCR. This antibody reacts with human. The Human IL-27 R alpha /WSX-1/TCCR PE-conjugated Antibody has been validated for the following applications: Flow Cytometry.

target :

IL-27 R alpha/WSX-1/TCCR

category :

Primary Antibodies

buffer :

Supplied in a saline solution containing BSA and Sodium Azide.

clonality :

Monoclonal

clone :

191106

conjugate :

Phycoerythrin

host :

Mouse

immunogen :

Mouse myeloma cell line NS0-derived recombinant human IL-27 R alpha /WSX-1/TCCR, Gly34-Lys516, Accession # Q6UWB1

isotype :

IgG2b

purity :

Protein A or G purified from hybridoma culture supernatant

species :

Human

specificity :

Detects human IL-27 R alpha /WSX-1/TCCR in direct ELISAs and Western blots. In direct ELISAs, no cross-reactivity with recombinant human gp130 or recombinant mouse IL-27 Ra is observed.

gene symbol :

IL27RA

top caption :

Detection of IL-27 Ra/WSX-1/TCCR antibody in Human PBMC lymphocytes antibody by Flow Cytometry.

accessionNumbers :

Q6UWB1

applications :

Flow Cytometry

USD :

419 USD

alt names :

class I cytokine receptor, CRL1IL-27R, Cytokine receptor-like 1, IL-27 R alpha, IL27R, IL27R alpha, IL27RA, IL-27RA, IL-27R-alpha, interleukin 27 receptor, alpha, interleukin-27 receptor subunit alpha, TCCR, TCCRIL-27 receptor subunit alpha, T-cell cytokine receptor type 1, Type I T-cell cytokine receptor, WSX-1, WSX1IL-27R subunit alpha, zcytor1

storage :

Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.

more info or order :

R&D Systems product webpage