product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human NKG2C/CD159c PE-conjugated Antibody
catalog :
FAB138P-025
quantity :
25 Tests (also 100 Tests)
price :
179 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
134591
reactivity :
human
application :
immunohistochemistry, immunocytochemistry, flow cytometry
more info or order :
citations: 73
Reference
S xe1 nchez Gaona N, Gallego Cort xe9 s A, Astorga Gamaza A, Rall xf3 n N, Benito J, Ruiz Mateos E, et al. NKG2C and NKG2A coexpression defines a highly functional antiviral NK population in spontaneous HIV control. JCI Insight. 2024;9: pubmed publisher
Lupo K, Panjwani M, Shahid S, Sottile R, Lawry C, Kolk G, et al. Engineered NKG2C + NK-like T cells exhibit superior antitumor efficacy while mitigating cytokine release syndrome. bioRxiv. 2024;: pubmed publisher
Thangaraj J, Coffey M, Lopez E, Kaufman D. Disruption of TGF-β signaling pathway is required to mediate effective killing of hepatocellular carcinoma by human iPSC-derived NK cells. Cell Stem Cell. 2024;31:1327-1343.e5 pubmed publisher
Felgueres M, Esteso G, Garc xed a Jim xe9 nez x, Dopazo A, Aguil xf3 N, Mestre Dur xe1 n C, et al. BCG priming followed by a novel interleukin combination activates Natural Killer cells to selectively proliferate and become anti-tumour long-lived effectors. Sci Rep. 2024;14:13133 pubmed publisher
Alekseeva N, Streltsova M, Vavilova J, Ustiuzhanina M, Palamarchuk A, Boyko A, et al. Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells. Pharmaceutics. 2024;16: pubmed publisher
Rubino V, Carriero F, Palatucci A, Giovazzino A, Leone S, Nicolella V, et al. Adaptive and Innate Cytotoxic Effectors in Chronic Lymphocytic Leukaemia (CLL) Subjects with Stable Disease. Int J Mol Sci. 2023;24: pubmed publisher
Israr M, Lam F, DeVoti J, Mace E, Papayannakos C, Abramson A, et al. PGE2 expression by HPV6/11-induced respiratory papillomas blocks NK cell activation in patients with recurrent respiratory papillomatosis. Eur J Immunol. 2023;53:e2250036 pubmed publisher
Shemesh A, Su Y, Calabrese D, Chen D, Arakawa Hoyt J, Roybal K, et al. Diminished cell proliferation promotes natural killer cell adaptive-like phenotype by limiting FcεRIγ expression. J Exp Med. 2022;219: pubmed publisher
Wahlen S, Matthijssens F, Van Loocke W, Taveirne S, Kiekens L, Persyn E, et al. The transcription factor RUNX2 drives the generation of human NK cells and promotes tissue residency. elife. 2022;11: pubmed publisher
Mikhailova V, Grebenkina P, Khokhlova E, Davydova A, Salloum Z, Tyshchuk E, et al. Pro- and Anti-Inflammatory Cytokines in the Context of NK Cell-Trophoblast Interactions. Int J Mol Sci. 2022;23: pubmed publisher
Palamarchuk A, Alekseeva N, Streltsova M, Ustiuzhanina M, Kobyzeva P, Kust S, et al. Increased Susceptibility of the CD57- NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response. Int J Mol Sci. 2021;22: pubmed publisher
Vieira V, Adland E, Malone D, Martin M, Groll A, Ansari M, et al. An HLA-I signature favouring KIR-educated Natural Killer cells mediates immune control of HIV in children and contrasts with the HLA-B-restricted CD8+ T-cell-mediated immune control in adults. PLoS Pathog. 2021;17:e1010090 pubmed publisher
Tuengel J, Ranchal S, Maslova A, Aulakh G, Papadopoulou M, Drissler S, et al. Characterization of Adaptive-like γδ T Cells in Ugandan Infants during Primary Cytomegalovirus Infection. Viruses. 2021;13: pubmed publisher
Woan K, Kim H, Bjordahl R, Davis Z, Gaidarova S, Goulding J, et al. Harnessing features of adaptive NK cells to generate iPSC-derived NK cells for enhanced immunotherapy. Cell Stem Cell. 2021;28:2062-2075.e5 pubmed publisher
Streltsova M, Ustiuzhanina M, Barsov E, Kust S, Velichinskii R, Kovalenko E. Telomerase Reverse Transcriptase Increases Proliferation and Lifespan of Human NK Cells without Immortalization. Biomedicines. 2021;9: pubmed publisher
Maas R, Hoogstad van Evert J, Van der Meer J, Mekers V, Rezaeifard S, Korman A, et al. TIGIT blockade enhances functionality of peritoneal NK cells with altered expression of DNAM-1/TIGIT/CD96 checkpoint molecules in ovarian cancer. Oncoimmunology. 2020;9:1843247 pubmed publisher
Anderko R, Rinaldo C, Mailliard R. IL-18 Responsiveness Defines Limitations in Immune Help for Specialized FcRγ- NK Cells. J Immunol. 2020;205:3429-3442 pubmed publisher
Tseng H, Xiong W, Badeti S, Yang Y, Ma M, Liu T, et al. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Commun. 2020;11:4810 pubmed publisher
Kobyzeva P, Streltsova M, Erokhina S, Kanevskiy L, Telford W, Sapozhnikov A, et al. CD56dim CD57- NKG2C+ NK cells retaining proliferative potential are possible precursors of CD57+ NKG2C+ memory-like NK cells. J Leukoc Biol. 2020;108:1379-1395 pubmed publisher
Gruber C, Calis J, Buta S, Evrony G, Martin J, Uhl S, et al. Complex Autoinflammatory Syndrome Unveils Fundamental Principles of JAK1 Kinase Transcriptional and Biochemical Function. Immunity. 2020;53:672-684.e11 pubmed publisher
Makanga D, Da Rin de Lorenzo F, David G, Willem C, Dubreuil L, Legrand N, et al. Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia. Cancers (Basel). 2020;12: pubmed publisher
Zhu H, Blum R, Bernareggi D, Ask E, Wu Z, Hoel H, et al. Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity. Cell Stem Cell. 2020;27:224-237.e6 pubmed publisher
Riese P, Trittel S, Pathirana R, Klawonn F, Cox R, Guzm xe1 n C. Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells. Vaccines (Basel). 2020;8: pubmed publisher
Wagstaffe H, Clutterbuck E, Bockstal V, Stoop J, Luhn K, Douoguih M, et al. Ebola virus glycoprotein stimulates IL-18-dependent natural killer cell responses. J Clin Invest. 2020;130:3936-3946 pubmed publisher
Dege C, Fegan K, Creamer J, Berrien Elliott M, Luff S, Kim D, et al. Potently Cytotoxic Natural Killer Cells Initially Emerge from Erythro-Myeloid Progenitors during Mammalian Development. Dev Cell. 2020;53:229-239.e7 pubmed publisher
Samarani S, Sagala P, Jantchou P, Grimard G, Faure C, Deslandres C, et al. Phenotypic and Functional Changes in Peripheral Blood Natural Killer Cells in Crohn Disease Patients. Mediators Inflamm. 2020;2020:6401969 pubmed publisher
Dogra P, Rancan C, Ma W, Toth M, Senda T, Carpenter D, et al. Tissue Determinants of Human NK Cell Development, Function, and Residence. Cell. 2020;180:749-763.e13 pubmed publisher
Ojo E, Sharma A, Liu R, Moreton S, Checkley Luttge M, Gupta K, et al. Membrane bound IL-21 based NK cell feeder cells drive robust expansion and metabolic activation of NK cells. Sci Rep. 2019;9:14916 pubmed publisher
Oh E, Min B, Li Y, Lian C, Hong J, Park G, et al. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect). Cancers (Basel). 2019;11: pubmed publisher
Pump W, Kraemer T, Huyton T, Hò G, Blasczyk R, Bade Doeding C. Between Innate and Adaptive Immune Responses: NKG2A, NKG2C, and CD8⁺ T Cell Recognition of HLA-E Restricted Self-Peptides Acquired in the Absence of HLA-Ia. Int J Mol Sci. 2019;20: pubmed publisher
Bradley T, Peppa D, Pedroza Pacheco I, Li D, Cain D, Henao R, et al. RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses. Cell. 2018;175:387-399.e17 pubmed publisher
Capuano C, Battella S, Pighi C, Franchitti L, Turriziani O, Morrone S, et al. Tumor-Targeting Anti-CD20 Antibodies Mediate In Vitro Expansion of Memory Natural Killer Cells: Impact of CD16 Affinity Ligation Conditions and In Vivo Priming. Front Immunol. 2018;9:1031 pubmed publisher
Wang E, Pjechova M, Nightingale K, Vlahava V, Patel M, Růcková E, et al. Suppression of costimulation by human cytomegalovirus promotes evasion of cellular immune defenses. Proc Natl Acad Sci U S A. 2018;115:4998-5003 pubmed publisher
Garand M, Goodier M, Owolabi O, Donkor S, Kampmann B, Sutherland J. Functional and Phenotypic Changes of Natural Killer Cells in Whole Blood during Mycobacterium tuberculosis Infection and Disease. Front Immunol. 2018;9:257 pubmed publisher
Feyaerts D, Kuret T, Van Cranenbroek B, van der Zeeuw Hingrez S, van der Heijden O, van der Meer A, et al. Endometrial natural killer (NK) cells reveal a tissue-specific receptor repertoire. Hum Reprod. 2018;33:441-451 pubmed publisher
Björklund A, Carlsten M, Sohlberg E, Liu L, Clancy T, Karimi M, et al. Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. Clin Cancer Res. 2018;24:1834-1844 pubmed publisher
Podhorzer A, Dirchwolf M, Machicote A, Belen S, Montal S, Paz S, et al. The Clinical Features of Patients with Chronic Hepatitis C Virus Infections Are Associated with Killer Cell Immunoglobulin-Like Receptor Genes and Their Expression on the Surface of Natural Killer Cells. Front Immunol. 2017;8:1912 pubmed publisher
Larsen M, Bayard C, Lepetitcorps H, Cohen Bittan J, Appay V, Boddaert J, et al. Elevated Neopterin Levels Predict Early Death in Older Hip-fracture Patients. EBioMedicine. 2017;26:157-164 pubmed publisher
López Montañés M, Alari Pahissa E, Sintes J, Martinez Rodriguez J, Muntasell A, Lopez Botet M. Antibody-Dependent NK Cell Activation Differentially Targets EBV-Infected Cells in Lytic Cycle and Bystander B Lymphocytes Bound to Viral Antigen-Containing Particles. J Immunol. 2017;199:656-665 pubmed publisher
Darboe A, Danso E, Clarke E, Umesi A, Touray E, Wegmüller R, et al. Enhancement of cytokine-driven NK cell IFN-γ production after vaccination of HCMV infected Africans. Eur J Immunol. 2017;47:1040-1050 pubmed publisher
van der Geest K, Wang Q, Eijsvogels T, Koenen H, Joosten I, Brouwer E, et al. Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study. Immun Ageing. 2017;14:5 pubmed publisher
Rölle A, Halenius A, Ewen E, Cerwenka A, Hengel H, Momburg F. CD2-CD58 interactions are pivotal for the activation and function of adaptive natural killer cells in human cytomegalovirus infection. Eur J Immunol. 2016;46:2420-2425 pubmed publisher
Goodier M, Rodríguez Galán A, Lusa C, Nielsen C, Darboe A, Moldoveanu A, et al. Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection. J Immunol. 2016;197:313-25 pubmed publisher
Rettman P, Willem C, David G, Riou R, Legrand N, Esbelin J, et al. New insights on the natural killer cell repertoire from a thorough analysis of cord blood cells. J Leukoc Biol. 2016;100:471-9 pubmed publisher
Cichocki F, Cooley S, Davis Z, DeFor T, Schlums H, Zhang B, et al. CD56dimCD57+NKG2C+ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT. Leukemia. 2016;30:456-63 pubmed publisher
Picardi A, Mengarelli A, Marino M, Gallo E, Benevolo M, Pescarmona E, et al. Up-regulation of activating and inhibitory NKG2 receptors in allogeneic and autologous hematopoietic stem cell grafts. J Exp Clin Cancer Res. 2015;34:98 pubmed publisher
Li W, Jiang Y, Wang X, Jin J, Qi Y, Chi X, et al. Natural Killer p46 Controls Hepatitis B Virus Replication and Modulates Liver Inflammation. PLoS ONE. 2015;10:e0135874 pubmed publisher
Marquardt N, Ivarsson M, Blom K, Gonzalez V, Braun M, Falconer K, et al. The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education. J Immunol. 2015;195:3262-72 pubmed publisher
Moraru M, Black L, Muntasell A, Portero F, López Botet M, Reyburn H, et al. NK Cell and Ig Interplay in Defense against Herpes Simplex Virus Type 1: Epistatic Interaction of CD16A and IgG1 Allotypes of Variable Affinities Modulates Antibody-Dependent Cellular Cytotoxicity and Susceptibility to Clinical Reactivation. J Immunol. 2015;195:1676-84 pubmed publisher
Dunphy S, Guinan K, Chorcora C, Jayaraman J, Traherne J, Trowsdale J, et al. 2DL1, 2DL2 and 2DL3 all contribute to KIR phenotype variability on human NK cells. Genes Immun. 2015;16:301-10 pubmed publisher
Nielsen C, White M, Bottomley C, Lusa C, Rodríguez Galán A, Turner S, et al. Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals. J Immunol. 2015;194:4657-67 pubmed publisher
van Meijgaarden K, Haks M, Caccamo N, Dieli F, Ottenhoff T, Joosten S. Human CD8+ T-cells recognizing peptides from Mycobacterium tuberculosis (Mtb) presented by HLA-E have an unorthodox Th2-like, multifunctional, Mtb inhibitory phenotype and represent a novel human T-cell subset. PLoS Pathog. 2015;11:e1004671 pubmed publisher
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson M, Kekäläinen E, et al. Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells. J Immunol. 2015;194:2467-71 pubmed publisher
Castley A, Berry C, French M, Fernandez S, Krueger R, Nolan D. Elevated plasma soluble CD14 and skewed CD16+ monocyte distribution persist despite normalisation of soluble CD163 and CXCL10 by effective HIV therapy: a changing paradigm for routine HIV laboratory monitoring?. PLoS ONE. 2014;9:e115226 pubmed publisher
Mikulak J, Bozzo L, Roberto A, Pontarini E, Tentorio P, Hudspeth K, et al. Dopamine inhibits the effector functions of activated NK cells via the upregulation of the D5 receptor. J Immunol. 2014;193:2792-800 pubmed publisher
Golden Mason L, Hahn Y, Strong M, Cheng L, Rosen H. Extracellular HCV-core protein induces an immature regulatory phenotype in NK cells: implications for outcome of acute infection. PLoS ONE. 2014;9:e103219 pubmed publisher
Killig M, Friedrichs B, Meisig J, Gentilini C, Blüthgen N, Loddenkemper C, et al. Tracking in vivo dynamics of NK cells transferred in patients undergoing stem cell transplantation. Eur J Immunol. 2014;44:2822-34 pubmed publisher
Hu X, Jiang Y, Li X, Gao Y, Guo X, Chi X, et al. Long-term effect on natural killer cells by interferon-α therapy on the outcomes of HCV infection. J Interferon Cytokine Res. 2014;34:366-75 pubmed publisher
Achour A, Baychelier F, Besson C, Arnoux A, Marty M, Hannoun L, et al. Expansion of CMV-mediated NKG2C+ NK cells associates with the development of specific de novo malignancies in liver-transplanted patients. J Immunol. 2014;192:503-11 pubmed publisher
Siewiera J, El Costa H, Tabiasco J, Berrebi A, Cartron G, Le Bouteiller P, et al. Human cytomegalovirus infection elicits new decidual natural killer cell effector functions. PLoS Pathog. 2013;9:e1003257 pubmed publisher
Charoudeh H, Terszowski G, Czaja K, Gonzalez A, Schmitter K, Stern M. Modulation of the natural killer cell KIR repertoire by cytomegalovirus infection. Eur J Immunol. 2013;43:480-7 pubmed publisher
Zhao J, Li Y, Jin L, Zhang S, Fan R, Sun Y, et al. Natural killer cells are characterized by the concomitantly increased interferon-? and cytotoxicity in acute resolved hepatitis B patients. PLoS ONE. 2012;7:e49135 pubmed publisher
Foley B, Cooley S, Verneris M, Curtsinger J, Luo X, Waller E, et al. Human cytomegalovirus (CMV)-induced memory-like NKG2C(+) NK cells are transplantable and expand in vivo in response to recipient CMV antigen. J Immunol. 2012;189:5082-8 pubmed publisher
Beziat V, Dalgard O, Asselah T, Halfon P, Bedossa P, Boudifa A, et al. CMV drives clonal expansion of NKG2C+ NK cells expressing self-specific KIRs in chronic hepatitis patients. Eur J Immunol. 2012;42:447-57 pubmed publisher
Björkström N, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, et al. Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus. J Exp Med. 2011;208:13-21 pubmed publisher
Le Garff Tavernier M, Decocq J, de Romeuf C, Parizot C, Dutertre C, Chapiro E, et al. Analysis of CD16+CD56dim NK cells from CLL patients: evidence supporting a therapeutic strategy with optimized anti-CD20 monoclonal antibodies. Leukemia. 2011;25:101-9 pubmed publisher
Angelini D, Zambello R, Galandrini R, Diamantini A, Placido R, Micucci F, et al. NKG2A inhibits NKG2C effector functions of ?? T cells: implications in health and disease. J Leukoc Biol. 2011;89:75-84 pubmed publisher
Beziat V, Descours B, Parizot C, Debre P, Vieillard V. NK cell terminal differentiation: correlated stepwise decrease of NKG2A and acquisition of KIRs. PLoS ONE. 2010;5:e11966 pubmed publisher
Spanholtz J, Tordoir M, Eissens D, Preijers F, van der Meer A, Joosten I, et al. High log-scale expansion of functional human natural killer cells from umbilical cord blood CD34-positive cells for adoptive cancer immunotherapy. PLoS ONE. 2010;5:e9221 pubmed publisher
Beziat V, Nguyen S, Exley M, Achour A, Simon T, Chevallier P, et al. Shaping of iNKT cell repertoire after unrelated cord blood transplantation. Clin Immunol. 2010;135:364-73 pubmed publisher
Brunetta E, Fogli M, Varchetta S, Bozzo L, Hudspeth K, Marcenaro E, et al. The decreased expression of Siglec-7 represents an early marker of dysfunctional natural killer-cell subsets associated with high levels of HIV-1 viremia. Blood. 2009;114:3822-30 pubmed publisher
Dulphy N, Haas P, Busson M, Belhadj S, Peffault De Latour R, Robin M, et al. An unusual CD56(bright) CD16(low) NK cell subset dominates the early posttransplant period following HLA-matched hematopoietic stem cell transplantation. J Immunol. 2008;181:2227-37 pubmed
Srivastava B, Srivastava M. Establishment and characterization of SRIK-NKL: a novel CD8+ natural killer/T cell line derived from a patient with leukemic phase of acute lymphoblastic lymphoma. Leuk Res. 2005;29:771-83 pubmed
product information
brand :
R&D Systems
master code :
FAB138P
SKU :
FAB138P-025
product name :
Human NKG2C/CD159c PE-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
seo description :
The Human NKG2C/CD159c PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to NKG2C/CD159c/KLRC2. This antibody reacts with human. The Human NKG2C/CD159c PE-conjugated Antibody has been validated for the following applications: Bioassay,Flow Cytometry,Immunohistochemistry,Immunocytochemistry.
target :
NKG2C/CD159c
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
134591
conjugate :
Phycoerythrin
dilution :
Flow Cytometry 10 uL/10^6 cells
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human NKG2C/CD159c and CD94
isotype :
IgG1
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human NKG2C/CD159c heterodimer with CD94 in flow cytometry. It does not cross-react with the human NKG2A/CD94 heterodimer or with the human CD94 homodimer.
gene symbol :
KLRC2
top caption :
Detection of NKG2C/CD159c antibody in Human PBMCs antibody by Flow Cytometry.
applications :
Bioassay,Flow Cytometry,Immunohistochemistry,Immunocytochemistry
USD :
179 USD
alt names :
CD159 antigen-like family member C, CD159c, CD159c antigen, killer cell lectin-like receptor subfamily C, member 2, KLRC2, MGC138244, NK cell receptor C, NKG2-C, NKG2-C type II integral membrane protein, NKG2CNKG2-C-activating NK receptor
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.