product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human MICA APC-conjugated Antibody
catalog :
FAB1300A-025
quantity :
25 Tests (also 100 Tests)
price :
179 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
159227
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 14
Reference
Zhao N, Pi R, Nguyen D, Ranganath T, Seiler C, Holmes S, et al. NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells. bioRxiv. 2024;: pubmed publisher
Wang C, Tan K, Wu Y, Zheng J, Wu J, Chen J. Functional MICA Variants Are Differentially Associated with Immune-Mediated Inflammatory Diseases. Int J Mol Sci. 2024;25: pubmed publisher
Salom xe9 B, Sfakianos J, Ranti D, Daza J, Bieber C, Charap A, et al. NKG2A and HLA-E define an alternative immune checkpoint axis in bladder cancer. Cancer Cell. 2022;40:1027-1043.e9 pubmed publisher
Petillo S, Capuano C, Molfetta R, Fionda C, Mekhloufi A, Pighi C, et al. Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition. Cell Death Dis. 2021;12:836 pubmed publisher
Møller S, Mellergaard M, Madsen M, Bermejo A, Jepsen S, Hansen M, et al. Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Front Immunol. 2020;11:1968 pubmed publisher
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed publisher
Björklund A, Carlsten M, Sohlberg E, Liu L, Clancy T, Karimi M, et al. Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. Clin Cancer Res. 2018;24:1834-1844 pubmed publisher
Tremblay McLean A, Bruneau J, Lebouché B, Lisovsky I, Song R, Bernard N. Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells. Viruses. 2017;9: pubmed publisher
Schilling D, Kühnel A, Tetzlaff F, Konrad S, Multhoff G. NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells. Cancer Immunol Immunother. 2015;64:599-608 pubmed publisher
Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR? activation. J Exp Med. 2013;210:2675-92 pubmed publisher
Wang W, Yu D, Sarnaik A, Yu B, Hall M, Morelli D, et al. Biomarkers on melanoma patient T cells associated with ipilimumab treatment. J Transl Med. 2012;10:146 pubmed publisher
MADRID A, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012;86:8693-704 pubmed publisher
Del Toro Arreola S, Arreygue Garcia N, Aguilar Lemarroy A, Cid Arregui A, Jimenez Perez M, Haramati J, et al. MHC class I-related chain A and B ligands are differentially expressed in human cervical cancer cell lines. Cancer Cell Int. 2011;11:15 pubmed publisher
Inagaki A, Ishida T, Yano H, Ishii T, Kusumoto S, Ito A, et al. Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC. Int J Cancer. 2009;125:212-21 pubmed publisher
product information
master code :
FAB1300A
SKU :
FAB1300A-025
product name :
Human MICA APC-conjugated Antibody
unit size :
25 Tests (also 100 Tests)
description :
The Human MICA APC-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to MICA. This antibody reacts with human. The Human MICA APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
MICA
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
159227
conjugate :
Allophycocyanin
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human MICA
isotype :
IgG2b
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human MICA in direct ELISAs and Western blots. In direct ELISAs, this antibody does not cross-react with recombinant human MICB.
gene symbol :
MICA
top caption :
Detection of MICA antibody in K562 Human Cell Line antibody by Flow Cytometry.
applications :
Flow Cytometry
USD :
179 USD
alt names :
FLJ60820, MGC111087, PERB11.1
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.