product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ULBP-2/5/6 PE-conjugated Antibody
catalog :
FAB1298P
quantity :
100 Tests
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
165903
reactivity :
human
application :
immunocytochemistry, neutralization, flow cytometry, FACS
more info or order :
citations: 34
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; loading ...; fig 2b
Zhu Y, Xie J, Shi J. Rac1/ROCK-driven membrane dynamics promote natural killer cell cytotoxicity via granzyme-induced necroptosis. BMC Biol. 2021;19:140 pubmed publisher
  • flow cytometry; human; loading ...; fig 1a
Hirano M, Imai Y, Kaito Y, Murayama T, Sato K, Ishida T, et al. Small-molecule HDAC and Akt inhibitors suppress tumor growth and enhance immunotherapy in multiple myeloma. J Exp Clin Cancer Res. 2021;40:110 pubmed publisher
Lee S, Chae S, Jang I, Oh S, Kim S, Lee S, et al. B7H6 is the predominant activating ligand driving natural killer cell-mediated killing in patients with liquid tumours: evidence from clinical, in silico, in vitro, and in vivo studies. EBioMedicine. 2024;110:105459 pubmed publisher
Liu J, Xing L, Li J, Wen K, Liu N, Liu Y, et al. Epigenetic regulation of CD38/CD48 by KDM6A mediates NK cell response in multiple myeloma. Nat Commun. 2024;15:1367 pubmed publisher
Koh E, Lee H, Son W, Park G, Bae J, Park Y. Antitumor effects of NK cells expanded by activation pre‑processing of autologous feeder cells before irradiation in colorectal cancer. Oncol Lett. 2023;25:232 pubmed publisher
de Vries N, van de Haar J, Veninga V, Chalabi M, Ijsselsteijn M, van der Ploeg M, et al. γδ T cells are effectors of immunotherapy in cancers with HLA class I defects. Nature. 2023;613:743-750 pubmed publisher
Gerace D, Zhou Q, Kenty J, Veres A, Sintov E, Wang X, et al. Engineering human stem cell-derived islets to evade immune rejection and promote localized immune tolerance. Cell Rep Med. 2023;4:100879 pubmed publisher
Chimienti R, Baccega T, Torchio S, Manenti F, Pellegrini S, Cospito A, et al. Engineering of immune checkpoints B7-H3 and CD155 enhances immune compatibility of MHC-I-/- iPSCs for β cell replacement. Cell Rep. 2022;40:111423 pubmed publisher
Murayama Y, Kasahara Y, Kubo N, Shin C, Imamura M, Oike N, et al. NKp44-based chimeric antigen receptor effectively redirects primary T cells against synovial sarcoma. Transl Oncol. 2022;25:101521 pubmed publisher
Bernareggi D, Xie Q, Prager B, Yun J, Cruz L, Pham T, et al. CHMP2A regulates tumor sensitivity to natural killer cell-mediated cytotoxicity. Nat Commun. 2022;13:1899 pubmed publisher
Seki T, Shimizu Y, Ishii K, Takahama Y, Kato K, Yano T. NK Cells Can Preferentially Target Prostate Cancer Stem-like Cells via the TRAIL/DR5 Signaling Pathway. Biomolecules. 2021;11: pubmed publisher
Van der Meer J, de Jonge P, van der Waart A, Geerlings A, Moonen J, Brummelman J, et al. CD34+ progenitor-derived NK cell and gemcitabine combination therapy increases killing of ovarian cancer cells in NOD/SCID/IL2Rgnull mice. Oncoimmunology. 2021;10:1981049 pubmed publisher
Portillo A, Hogg R, Poznanski S, Rojas E, Cashell N, Hammill J, et al. Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors. iScience. 2021;24:102619 pubmed publisher
Carré T, Thiery J, Janji B, Terry S, Gros G, Meurice G, et al. Selection of tumor‑resistant variants following sustained natural killer cell‑mediated immune stress. Oncol Rep. 2021;45:582-594 pubmed publisher
Goldenson B, Zhu H, Wang Y, Heragu N, Bernareggi D, Ruiz Cisneros A, et al. Umbilical Cord Blood and iPSC-Derived Natural Killer Cells Demonstrate Key Differences in Cytotoxic Activity and KIR Profiles. Front Immunol. 2020;11:561553 pubmed publisher
Ponath V, Frech M, Bittermann M, Al Khayer R, Neubauer A, Brendel C, et al. The Oncoprotein SKI Acts as A Suppressor of NK Cell-Mediated Immunosurveillance in PDAC. Cancers (Basel). 2020;12: pubmed publisher
Møller S, Mellergaard M, Madsen M, Bermejo A, Jepsen S, Hansen M, et al. Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells. Front Immunol. 2020;11:1968 pubmed publisher
Makanga D, Da Rin de Lorenzo F, David G, Willem C, Dubreuil L, Legrand N, et al. Genetic and Molecular Basis of Heterogeneous NK Cell Responses against Acute Leukemia. Cancers (Basel). 2020;12: pubmed publisher
Fasbender F, Obholzer M, Metzler S, St xf6 ber R, Hengstler J, Watzl C. Enhanced activation of human NK cells by drug-exposed hepatocytes. Arch Toxicol. 2020;94:439-448 pubmed publisher
Jennings V, Scott G, Rose A, Scott K, Migneco G, Keller B, et al. Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition. Mol Ther. 2019;27:1139-1152 pubmed publisher
Iwasa M, Harada T, Oda A, Bat Erdene A, Teramachi J, Tenshin H, et al. PD-L1 upregulation in myeloma cells by panobinostat in combination with interferon-γ. Oncotarget. 2019;10:1903-1917 pubmed publisher
Han Y, Xie W, Song D, Powell D. Control of triple-negative breast cancer using ex vivo self-enriched, costimulated NKG2D CAR T cells. J Hematol Oncol. 2018;11:92 pubmed publisher
Tomic A, Varanasi P, Golemac M, Malic S, Riese P, Borst E, et al. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand. PLoS Pathog. 2016;12:e1006015 pubmed publisher
Lin X, Huang M, Xie F, Zhou H, Yang J, Huang Q. Gemcitabine inhibits immune escape of pancreatic cancer by down regulating the soluble ULBP2 protein. Oncotarget. 2016;7:70092-70099 pubmed publisher
Vasu S, He S, Cheney C, Gopalakrishnan B, Mani R, Lozanski G, et al. Decitabine enhances anti-CD33 monoclonal antibody BI 836858-mediated natural killer ADCC against AML blasts. Blood. 2016;127:2879-89 pubmed publisher
Lee S, Kang W, Yoon Y, Jin J, Song H, Her J, et al. Natural killer (NK) cells inhibit systemic metastasis of glioblastoma cells and have therapeutic effects against glioblastomas in the brain. BMC Cancer. 2015;15:1011 pubmed publisher
Parrish C, Scott G, Migneco G, Scott K, Steele L, Ilett E, et al. Oncolytic reovirus enhances rituximab-mediated antibody-dependent cellular cytotoxicity against chronic lymphocytic leukaemia. Leukemia. 2015;29:1799-810 pubmed publisher
Uhlenbrock F, Hagemann Jensen M, Kehlet S, Andresen L, Pastorekova S, Skov S. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. J Immunol. 2014;193:1654-65 pubmed publisher
Wang R, Sun P. Natural killer cell-mediated shedding of ULBP2. PLoS ONE. 2014;9:e91133 pubmed publisher
Jacobs S, Plessers J, Pinxteren J, Roobrouck V, Verfaillie C, Van Gool S. Mutual interaction between human multipotent adult progenitor cells and NK cells. Cell Transplant. 2014;23:1099-110 pubmed publisher
Wang R, Jaw J, Stutzman N, Zou Z, Sun P. Natural killer cell-produced IFN-? and TNF-? induce target cell cytolysis through up-regulation of ICAM-1. J Leukoc Biol. 2012;91:299-309 pubmed publisher
Jensen H, Andresen L, Nielsen J, Christensen J, Skov S. Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression. PLoS ONE. 2011;6:e23023 pubmed publisher
Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva Nilsson L. Thermal- and oxidative stress causes enhanced release of NKG2D ligand-bearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS ONE. 2011;6:e16899 pubmed publisher
Cho D, Shook D, Shimasaki N, Chang Y, Fujisaki H, Campana D. Cytotoxicity of activated natural killer cells against pediatric solid tumors. Clin Cancer Res. 2010;16:3901-9 pubmed publisher
product information
master code :
FAB1298P
SKU :
FAB1298P
product name :
Human ULBP-2/5/6 PE-conjugated Antibody
unit size :
100 Tests
description :
The Human ULBP-2/5/6 PE-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to ULBP-2/5/6. This antibody reacts with human. The Human ULBP-2/5/6 PE-conjugated Antibody has been validated for the following applications: Flow Cytometry,FACS,CAR-T (Flow Cytometry),Neutralization,Immunocytochemistry.
target :
ULBP-2/5/6
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
165903
conjugate :
Phycoerythrin
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human ULBP-2, Accession # Q9BZM5
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human ULBP-2 and human RAET1L/ULBP-6 in direct ELISA and stains cells transfected with human ULBP-2, human ULBP-5 or human RAET1L/ULBP-6 in flow cytometry. In direct ELISA, 11% cross-reactivity with recombinant human ULBP5 is observed. It does not stain cells transfected with human ULBP-1 or human ULBP-3 in flow cytometry.
top caption :
Detection of ULBP-2/5/6 antibody in HT1080 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
Q9BZM5
applications :
FACS,Flow Cytometry,CAR-T (Flow Cytometry),Neutralization,Immunocytochemistry
USD :
479 USD
alt names :
ALCAN-alpha, N2DL2, NKG2DL2, RAET1G, RAET1H, RAET1L, UL16 binding protein 2, ULBP2, ULBP5, ULBP6
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.