product summary
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company name :
R&D Systems
product type :
antibody
product name :
Human ULBP-2/5/6 APC-conjugated Antibody
catalog :
FAB1298A
quantity :
100 Tests
price :
509 USD
clonality :
monoclonal
host :
mouse
conjugate :
APC
clone name :
165903
reactivity :
human
application :
flow cytometry
more info or order :
R&D Systems product webpage
citations: 23
Reference
Zhao N, Pi R, Nguyen D, Ranganath T, Seiler C, Holmes S, et al. NKp30 and NKG2D contribute to natural killer recognition of HIV-infected cells. bioRxiv. 2024;: pubmed publisher
Aublin Gex A, Jacolin F, Diaz O, Jacquemin C, Mar xe7 ais A, Walzer T, et al. Tethering of hexokinase 2 to mitochondria promotes resistance of liver cancer cells to natural killer cell cytotoxicity. Eur J Immunol. 2024;54:e2350954 pubmed publisher
Li Y, Zhou Y, Kim Y, Zhu Y, Ma F, Yu J, et al. Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy. Cell Rep Med. 2021;2:100449 pubmed publisher
Fu R, Yu F, Wu W, Liu J, Li J, Guo F, et al. Bufalin enhances the killing efficacy of NK cells against hepatocellular carcinoma by inhibiting MICA shedding. Int Immunopharmacol. 2021;101:108195 pubmed publisher
Zhong X, Liao H, Hu S, Luo K, Zhu H. The diterpenoid adenanthin upregulates the expression of natural killer group 2D receptor ligands in hepatocellular carcinoma cells. Mol Cell Probes. 2021;59:101759 pubmed publisher
Høgh R, Droujinine A, Møller S, Jepsen S, Mellergaard M, Andresen L, et al. Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity. J Immunol. 2020;204:1746-1759 pubmed publisher
Suzuki D, Flahou C, Yoshikawa N, Stirblyte I, Hayashi Y, Sawaguchi A, et al. iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity. Stem Cell Reports. 2020;14:49-59 pubmed publisher
Mallmann Gottschalk N, Sax Y, Kimmig R, Lang S, Brandau S. EGFR-Specific Tyrosine Kinase Inhibitor Modifies NK Cell-Mediated Antitumoral Activity against Ovarian Cancer Cells. Int J Mol Sci. 2019;20: pubmed publisher
Chollat Namy M, Ben Safta Saadoun T, Haferssas D, Meurice G, Chouaib S, Thiery J. The pharmalogical reactivation of p53 function improves breast tumor cell lysis by granzyme B and NK cells through induction of autophagy. Cell Death Dis. 2019;10:695 pubmed publisher
Bhat J, Dubin S, Dananberg A, Quabius E, Fritsch J, Dowds C, et al. Histone Deacetylase Inhibitor Modulates NKG2D Receptor Expression and Memory Phenotype of Human Gamma/Delta T Cells Upon Interaction With Tumor Cells. Front Immunol. 2019;10:569 pubmed publisher
Tremblay McLean A, Coenraads S, Kiani Z, Dupuy F, Bernard N. Expression of ligands for activating natural killer cell receptors on cell lines commonly used to assess natural killer cell function. BMC Immunol. 2019;20:8 pubmed publisher
Breman E, Demoulin B, Agaugué S, Mauen S, Michaux A, Springuel L, et al. Overcoming Target Driven Fratricide for T Cell Therapy. Front Immunol. 2018;9:2940 pubmed publisher
Björklund A, Carlsten M, Sohlberg E, Liu L, Clancy T, Karimi M, et al. Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML. Clin Cancer Res. 2018;24:1834-1844 pubmed publisher
Kamei R, Yoshimura K, Yoshino S, Inoue M, Asao T, Fuse M, et al. Expression levels of UL16 binding protein 1 and natural killer group 2 member D affect overall survival in patients with gastric cancer following gastrectomy. Oncol Lett. 2018;15:747-754 pubmed publisher
Tremblay McLean A, Bruneau J, Lebouché B, Lisovsky I, Song R, Bernard N. Expression Profiles of Ligands for Activating Natural Killer Cell Receptors on HIV Infected and Uninfected CD4? T Cells. Viruses. 2017;9: pubmed publisher
Huang W, Easom N, Tang X, Gill U, Singh H, Robertson F, et al. T Cells Infiltrating Diseased Liver Express Ligands for the NKG2D Stress Surveillance System. J Immunol. 2017;198:1172-1182 pubmed publisher
Leung W, Vong Q, Lin W, Bouck D, Wendt S, Sullivan E, et al. PRL-3 mediates the protein maturation of ULBP2 by regulating the tyrosine phosphorylation of HSP60. J Immunol. 2015;194:2930-41 pubmed publisher
Uhlenbrock F, Hagemann Jensen M, Kehlet S, Andresen L, Pastorekova S, Skov S. The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway. J Immunol. 2014;193:1654-65 pubmed publisher
Leung W, Vong Q, Lin W, Janke L, Chen T, Leung W. Modulation of NKG2D ligand expression and metastasis in tumors by spironolactone via RXR? activation. J Exp Med. 2013;210:2675-92 pubmed publisher
Jardine L, Hambleton S, Bigley V, Pagan S, Wang X, Collin M. Sensitizing primary acute lymphoblastic leukemia to natural killer cell recognition by induction of NKG2D ligands. Leuk Lymphoma. 2013;54:167-73 pubmed publisher
MADRID A, Ganem D. Kaposi's sarcoma-associated herpesvirus ORF54/dUTPase downregulates a ligand for the NK activating receptor NKp44. J Virol. 2012;86:8693-704 pubmed publisher
Dasgupta A, Shields J, Spencer H. Treatment of a solid tumor using engineered drug-resistant immunocompetent cells and cytotoxic chemotherapy. Hum Gene Ther. 2012;23:711-21 pubmed publisher
Jensen H, Andresen L, Nielsen J, Christensen J, Skov S. Vesicular stomatitis virus infection promotes immune evasion by preventing NKG2D-ligand surface expression. PLoS ONE. 2011;6:e23023 pubmed publisher
product information
master code :
FAB1298A
SKU :
FAB1298A
product name :
Human ULBP-2/5/6 APC-conjugated Antibody
unit size :
100 Tests
description :
The Human ULBP-2/5/6 APC-conjugated Antibody from R&D Systems is a mouse monoclonal antibody to ULBP-2/5/6. This antibody reacts with human. The Human ULBP-2/5/6 APC-conjugated Antibody has been validated for the following applications: Flow Cytometry.
target :
ULBP-2/5/6
category :
Primary Antibodies
buffer :
Supplied in a saline solution containing BSA and Sodium Azide.
clonality :
Monoclonal
clone :
165903
conjugate :
Allophycocyanin
host :
Mouse
immunogen :
BaF3 mouse pro-B cell line transfected with human ULBP-2, Accession # Q9BZM5
isotype :
IgG2a
purity :
Protein A or G purified from hybridoma culture supernatant
species :
Human
specificity :
Detects human ULBP-2 and human RAET1L/ULBP-6 in direct ELISA and stains cells transfected with human ULBP-2, human ULBP-5 or human RAET1L/ULBP-6 in flow cytometry. In direct ELISA, 11% cross-reactivity with recombinant human ULBP5 is observed. It does not stain cells transfected with human ULBP-1 or human ULBP-3 in flow cytometry.
top caption :
Detection of ULBP-2/5/6 antibody in HT1080 Human Cell Line antibody by Flow Cytometry.
accessionNumbers :
Q9BZM5
applications :
Flow Cytometry
USD :
509 USD
alt names :
ALCAN-alpha, N2DL2, NKG2DL2, RAET1G, RAET1H, RAET1L, UL16 binding protein 2, ULBP2, ULBP5, ULBP6
storage :
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 ░C as supplied.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.