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company name :
R&D Systems
product type :
other
product name :
Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate
catalog :
ES010
quantity :
1 mg
price :
281 USD
more info or order :
citations: 26
Reference
Zatovicova M, Kajanová I, Takacova M, Jelenska L, Sedlakova O, Labudova M, et al. ADAM10 mediates shedding of carbonic anhydrase IX ectodomain non‑redundantly to ADAM17. Oncol Rep. 2023;49: pubmed publisher
Alsolaiss J, Alomran N, Hawkins L, Casewell N. Commercial Antivenoms Exert Broad Paraspecific Immunological Binding and In Vitro Inhibition of Medically Important Bothrops Pit Viper Venoms. Toxins (Basel). 2022;15: pubmed publisher
Kazandjian T, Hamilton B, Robinson S, Hall S, Bartlett K, ROWLEY P, et al. Physiological constraints dictate toxin spatial heterogeneity in snake venom glands. BMC Biol. 2022;20:148 pubmed publisher
Kumar L, Planas Iglesias J, Harms C, Kamboj S, Wright D, Klein Seetharaman J, et al. Activity-dependent interdomain dynamics of matrix metalloprotease-1 on fibrin. Sci Rep. 2020;10:20615 pubmed publisher
Falkowski K, Bielecka E, Thøgersen I, Bocheńska O, Płaza K, Kalińska M, et al. Kallikrein-Related Peptidase 14 Activates Zymogens of Membrane Type Matrix Metalloproteinases (MT-MMPs)-A CleavEx Based Analysis. Int J Mol Sci. 2020;21: pubmed publisher
Kumar L, Colomb W, Czerski J, Cox C, Sarkar S. Efficient protease based purification of recombinant matrix metalloprotease-1 in E. coli. Protein Expr Purif. 2018;148:59-67 pubmed publisher
Schaal J, Maretzky T, Tran D, Tran P, Tongaonkar P, Blobel C, et al. Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme. J Biol Chem. 2018;293:2725-2734 pubmed publisher
Peng T, Zhou W, Guo F, Wu H, Wang C, Wang L, et al. Centrosomal protein 55 activates NF-κB signalling and promotes pancreatic cancer cells aggressiveness. Sci Rep. 2017;7:5925 pubmed publisher
Lee H, Diaz M, Price K, Ozuna J, Zhang S, Sevick Muraca E, et al. Fluid shear stress activates YAP1 to promote cancer cell motility. Nat Commun. 2017;8:14122 pubmed publisher
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, et al. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep. 2016;6:35598 pubmed publisher
Chan C, Pan Y, Nyberg K, Marra M, Lim E, Jones S, et al. Tumour-suppressor microRNAs regulate ovarian cancer cell physical properties and invasive behaviour. Open Biol. 2016;6: pubmed
Zhang L, Morrison A, Thibodeau P. Interdomain Contacts and the Stability of Serralysin Protease from Serratia marcescens. PLoS ONE. 2015;10:e0138419 pubmed publisher
Duan J, Rapti M, Tsigkou A, Lee M. Expanding the Activity of Tissue Inhibitors of Metalloproteinase (TIMP)-1 against Surface-Anchored Metalloproteinases by the Replacement of Its C-Terminal Domain: Implications for Anti-Cancer Effects. PLoS ONE. 2015;10:e0136384 pubmed publisher
Hernandez Guillamon M, Mawhirt S, Blais S, Montaner J, Neubert T, Rostagno A, et al. Sequential Amyloid-β Degradation by the Matrix Metalloproteases MMP-2 and MMP-9. J Biol Chem. 2015;290:15078-91 pubmed publisher
Zhu W, Tao L, Quick M, Joyce J, Qu J, Luo Z. Sensing cytosolic RpsL by macrophages induces lysosomal cell death and termination of bacterial infection. PLoS Pathog. 2015;11:e1004704 pubmed publisher
Butterworth M, Zhang L, Liu X, SHANKS R, Thibodeau P. Modulation of the epithelial sodium channel (ENaC) by bacterial metalloproteases and protease inhibitors. PLoS ONE. 2014;9:e100313 pubmed publisher
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed publisher
Ramani V, Sanderson R. Chemotherapy stimulates syndecan-1 shedding: a potentially negative effect of treatment that may promote tumor relapse. Matrix Biol. 2014;35:215-22 pubmed publisher
Hayes C, Dey D, Palavicini J, Wang H, Patkar K, Minond D, et al. Striking reduction of amyloid plaque burden in an Alzheimer's mouse model after chronic administration of carmustine. BMC Med. 2013;11:81 pubmed publisher
Ingvarsen S, Porse A, Erpicum C, Maertens L, Jürgensen H, Madsen D, et al. Targeting a single function of the multifunctional matrix metalloprotease MT1-MMP: impact on lymphangiogenesis. J Biol Chem. 2013;288:10195-204 pubmed publisher
Fujisawa T, Rubin B, Suzuki A, Patel P, Gahl W, Joshi B, et al. Cysteamine suppresses invasion, metastasis and prolongs survival by inhibiting matrix metalloproteinases in a mouse model of human pancreatic cancer. PLoS ONE. 2012;7:e34437 pubmed publisher
Walsh L, Damjanovski S. IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-?1 resulting in epithelial to mesenchymal transition. Cell Commun Signal. 2011;9:10 pubmed publisher
Ding Z, Kng Y, Yang H, Ke Z, Zhuo L. An orally available small imidazolium salt ameliorates inflammation and fibrosis in a murine model of cholestasis. Lab Invest. 2011;91:752-63 pubmed publisher
Koenen R, Pruessmeyer J, Soehnlein O, Fraemohs L, Zernecke A, Schwarz N, et al. Regulated release and functional modulation of junctional adhesion molecule A by disintegrin metalloproteinases. Blood. 2009;113:4799-809 pubmed publisher
Yamashita Y, Kawashima I, Yanai Y, Nishibori M, Richards J, Shimada M. Hormone-induced expression of tumor necrosis factor alpha-converting enzyme/A disintegrin and metalloprotease-17 impacts porcine cumulus cell oocyte complex expansion and meiotic maturation via ligand activation of the epidermal growth factor recepto. Endocrinology. 2007;148:6164-75 pubmed
Tellier E, Canault M, Rebsomen L, Bonardo B, Juhan Vague I, Nalbone G, et al. The shedding activity of ADAM17 is sequestered in lipid rafts. Exp Cell Res. 2006;312:3969-80 pubmed
product information
master code :
ES010
SKU :
ES010
product name :
Mca-KPLGL-Dpa-AR-NH2 Fluorogenic Peptide Substrate
unit size :
1 mg
target :
Protease Substrates
category :
Activity Assays
species :
Multi-Species
source short :
Synthetic
extended description :
Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, ADAM10, ADAM17/TACE, Cathepsin D, and Cathepsin E
USD :
281 USD
product details :
Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, ADAM10, ADAM17/TACE, Cathepsin D, and Cathepsin E
storage :
Samples are stable for up to twelve months from date of receipt at -20░ C to -70░ C. The substrate can be aliquoted and stored -20░ C to -70░ C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.