product summary
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company name :
R&D Systems
product type :
other
product name :
Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate
catalog :
ES004
quantity :
1 mg
price :
281 USD
more info or order :
R&D Systems product webpage
citations: 7
Reference
Stern N, Gacs A, T xe1 trai E, Flachner B, Hajd xfa I, Dobi K, et al. Dual Inhibitors of AChE and BACE-1 for Reducing Aβ in Alzheimer's Disease: From In Silico to In Vivo. Int J Mol Sci. 2022;23: pubmed publisher
Zou Y, Hu J, Huang W, Zhu L, Shao M, Dordoe C, et al. The botanical origin and antioxidant, anti-BACE1 and antiproliferative properties of bee pollen from different regions of South Korea. BMC Complement Med Ther. 2020;20:236 pubmed publisher
Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, et al. Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol Biol. 2018;430:1566-1576 pubmed publisher
Netzer W, Bettayeb K, Sinha S, Flajolet M, Greengard P, Bustos V. Gleevec shifts APP processing from a β-cleavage to a nonamyloidogenic cleavage. Proc Natl Acad Sci U S A. 2017;114:1389-1394 pubmed publisher
Del Prete D, Suski J, Oulès B, Debayle D, Gay A, Lacas Gervais S, et al. Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes. J Alzheimers Dis. 2017;55:1549-1570 pubmed publisher
Na C, Jeon S, Zhang G, Olson G, Chae C. Inhibition of amyloid beta-peptide production by blockage of beta-secretase cleavage site of amyloid precursor protein. J Neurochem. 2007;101:1583-95 pubmed
Andrau D, Dumanchin Njock C, Ayral E, Vizzavona J, Farzan M, Boisbrun M, et al. BACE1- and BACE2-expressing human cells: characterization of beta-amyloid precursor protein-derived catabolites, design of a novel fluorimetric assay, and identification of new in vitro inhibitors. J Biol Chem. 2003;278:25859-66 pubmed
product information
master code :
ES004
SKU :
ES004
product name :
Mca-SEVNLDAEFRK(Dnp)RR-NH2 Fluorogenic Peptide Substrate
unit size :
1 mg
target :
Protease Substrates
category :
Activity Assays
species :
Multi-Species
theoretical molecular weight :
2001 Da
details of functionality :
The peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence. The substrate contains the Swedish mutation of the amyloid precursor protein (APP) ▀-secretase cleavage site. A K-R-R sequence is added for easy solubilization. It can be used to measure the activity of BACE-1 (R D Systems, Catalog # 931-AS) and thimet oligopeptidase (Koike, H. et al ., 1999, J. Biochem. 126 :235).
applications :
Bioactivity
extended description :
Substrate for BACE-1
USD :
281 USD
product details :
Substrate for BACE-1
storage :
Samples are stable for up to twelve months from date of receipt at -20░ C to -70░ C. The substrate can be aliquoted and stored -20░ C to -70░ C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.