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company name :
R&D Systems
product type :
other
product name :
Mca-PLAQAV-Dpa-RSSSR-NH2 Fluorogenic Peptide Substrate
catalog :
ES003
quantity :
1 mg
price :
281 USD
more info or order :
R&D Systems product webpage
citations: 20
Reference
Xu S, Tan S, Romanos P, Reedy J, Zhang Y, Mansour M, et al. Blocking HXA3-mediated neutrophil elastase release during S. pneumoniae lung infection limits pulmonary epithelial barrier disruption and bacteremia. MBio. 2024;15:e0185624 pubmed publisher
Segura J, Ireland J, Zou Z, Roth G, Buchwald J, Shen T, et al. HIV-1 release requires Nef-induced caspase activation. PLoS ONE. 2023;18:e0281087 pubmed publisher
Zhukovsky N, Silvano M, Filloux T, Gonzalez S, Krause K. Alpha-1 Antitrypsin Reduces Disease Progression in a Mouse Model of Charcot-Marie-Tooth Type 1A: A Role for Decreased Inflammation and ADAM-17 Inhibition. Int J Mol Sci. 2022;23: pubmed publisher
Scherschinski L, Prem M, Kremenetskaia I, Tinhofer I, Vajkoczy P, Karbe A, et al. Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma. Int J Mol Sci. 2022;23: pubmed publisher
Saha N, Xu K, Zhu Z, Robev D, Kalidindi T, Xu Y, et al. Inhibitory monoclonal antibody targeting ADAM17 expressed on cancer cells. Transl Oncol. 2022;15:101265 pubmed publisher
Shin D, Kim S, Choi M, Bae Y, Han C, Choi B, et al. Oncogenic KRAS promotes growth of lung cancer cells expressing SLC3A2-NRG1 fusion via ADAM17-mediated shedding of NRG1. Oncogene. 2022;41:280-292 pubmed publisher
Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, et al. Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰. EBioMedicine. 2019;49:291-304 pubmed publisher
Ye Y, Toczek J, Gona K, Kim H, Han J, Razavian M, et al. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Sci Rep. 2018;8:11647 pubmed publisher
Bae E, Kim I, Choi H, Kim H, Kim C, Ma S, et al. Tumor necrosis factor α-converting enzyme inhibitor attenuates lipopolysaccharide-induced reactive oxygen species and mitogen-activated protein kinase expression in human renal proximal tubule epithelial cells. Korean J Physiol Pharmacol. 2018;22:135-143 pubmed publisher
Schaal J, Maretzky T, Tran D, Tran P, Tongaonkar P, Blobel C, et al. Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme. J Biol Chem. 2018;293:2725-2734 pubmed publisher
González Foruria I, Santulli P, Chouzenoux S, Carmona F, Chapron C, Batteux F. Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis. Mol Hum Reprod. 2017;23:488-499 pubmed publisher
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, et al. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep. 2016;6:35598 pubmed publisher
Ezekwe E, Weng C, Duncan J. ADAM10 Cell Surface Expression but Not Activity Is Critical for Staphylococcus aureus ?-Hemolysin-Mediated Activation of the NLRP3 Inflammasome in Human Monocytes. Toxins (Basel). 2016;8:95 pubmed publisher
Lajoie L, Congy Jolivet N, Bolzec A, Gouilleux Gruart V, Sicard E, Sung H, et al. ADAM17-mediated shedding of Fc?RIIIA on human NK cells: identification of the cleavage site and relationship with activation. J Immunol. 2014;192:741-51 pubmed publisher
Ramdas V, McBride M, Denby L, Baker A. Canonical transforming growth factor-? signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29. Am J Pathol. 2013;183:1885-1896 pubmed publisher
Al Tamimi M, Tan C, Qiao J, Pennings G, Javadzadegan A, Yong A, et al. Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vessels. Blood. 2012;119:4311-20 pubmed publisher
Jiang H, Hampel H, Prvulovic D, Wallin A, Blennow K, Li R, et al. Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease. Mol Neurodegener. 2011;6:69 pubmed publisher
Reiss K, Cornelsen I, Husmann M, Gimpl G, Bhakdi S. Unsaturated fatty acids drive disintegrin and metalloproteinase (ADAM)-dependent cell adhesion, proliferation, and migration by modulating membrane fluidity. J Biol Chem. 2011;286:26931-42 pubmed publisher
Canault M, Leroyer A, Peiretti F, Leseche G, Tedgui A, Bonardo B, et al. Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am J Pathol. 2007;171:1713-23 pubmed
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
product information
master code :
ES003
SKU :
ES003
product name :
Mca-PLAQAV-Dpa-RSSSR-NH2 Fluorogenic Peptide Substrate
unit size :
1 mg
target :
Protease Substrates
category :
Activity Assays
purity :
>95%, by HPLC.
species :
Multi-Species
theoretical molecular weight :
1638 Da
details of functionality :
The peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence. It is an excellent substrate for tumor necrosis factor-alpha converting enzyme (TACE or ADAM17) and related enzymes such as ADAM8, ADAM9 and ADAM10. The peptide sequence is derived from the pro tumor necrosis factor-alpha (TNF-alpha ). The cleavage site by TACE/ADAM17 and ADAM10 is the peptide bond between Ala and Val.
applications :
Bioactivity
extended description :
Substrate for TACE, ADAM9, and ADAM10
USD :
281 USD
product details :
Substrate for TACE, ADAM9, and ADAM10
storage :
Samples are stable for up to twelve months from date of receipt at -20░ C to -70░ C. The substrate can be aliquoted and stored -20░ C to -70░ C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.