product summary
Loading...
company name :
R&D Systems
product type :
other
product name :
Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate
catalog :
ES002
quantity :
1 mg
price :
281 USD
more info or order :
R&D Systems product webpage
citations: 15
Reference
Yu Q, Tang X, HART T, Homer R, Belperron A, Bockenstedt L, et al. Secretory leukocyte protease inhibitor influences periarticular joint inflammation in B. burgdorferi-infected mice. bioRxiv. 2025;: pubmed publisher
Lee H, Assaraf R, Subramanian S, Goetschius D, Bieri J, DiNunno N, et al. Infectious parvovirus B19 circulates in the blood coated with active host protease inhibitors. Nat Commun. 2024;15:9543 pubmed publisher
Sui L, Wang S, Ganguly D, El Rayes T, Askeland C, B xf8 rretzen A, et al. PRSS2 remodels the tumor microenvironment via repression of Tsp1 to stimulate tumor growth and progression. Nat Commun. 2022;13:7959 pubmed publisher
Op den Brouw B, Coimbra F, Casewell N, Ali S, Vonk F, Fry B. A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties. Int J Mol Sci. 2021;22: pubmed publisher
Bertran A, Khomiak D, Konopka A, Rejmak E, Bulska E, Seco J, et al. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg Chem. 2020;94:103365 pubmed publisher
Matsubara Y, Matsumoto T, Koseki J, Kaneko A, Aiba S, Yamasaki K. Inhibition of Human Kallikrein 5 Protease by Triterpenoids from Natural Sources. Molecules. 2017;22: pubmed publisher
Fortelny N, Butler G, Overall C, Pavlidis P. Protease-Inhibitor Interaction Predictions: Lessons on the Complexity of Protein-Protein Interactions. Mol Cell Proteomics. 2017;16:1038-1051 pubmed publisher
Zhao L, Hua T, CROWLEY C, Ru H, Ni X, Shaw N, et al. Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage. Cell Res. 2014;24:344-58 pubmed publisher
Fortugno P, Bresciani A, Paolini C, Pazzagli C, El Hachem M, D Alessio M, et al. Proteolytic activation cascade of the Netherton syndrome-defective protein, LEKTI, in the epidermis: implications for skin homeostasis. J Invest Dermatol. 2011;131:2223-32 pubmed publisher
Ramani V, Haun R. The extracellular matrix protein fibronectin is a substrate for kallikrein 7. Biochem Biophys Res Commun. 2008;369:1169-73 pubmed publisher
Fernández I, Ständker L, Mägert H, Forssmann W, Gimenez Gallego G, Romero A. Crystal structure of human epidermal kallikrein 7 (hK7) synthesized directly in its native state in E. coli: insights into the atomic basis of its inhibition by LEKTI domain 6 (LD6). J Mol Biol. 2008;377:1488-97 pubmed publisher
List K, Currie B, Scharschmidt T, Szabo R, Shireman J, Molinolo A, et al. Autosomal ichthyosis with hypotrichosis syndrome displays low matriptase proteolytic activity and is phenocopied in ST14 hypomorphic mice. J Biol Chem. 2007;282:36714-23 pubmed
Canault M, Leroyer A, Peiretti F, Leseche G, Tedgui A, Bonardo B, et al. Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1. Am J Pathol. 2007;171:1713-23 pubmed
Zhou B, Peyton M, He B, Liu C, Girard L, Caudler E, et al. Targeting ADAM-mediated ligand cleavage to inhibit HER3 and EGFR pathways in non-small cell lung cancer. Cancer Cell. 2006;10:39-50 pubmed
Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, et al. Distinct roles for cysteine cathepsin genes in multistage tumorigenesis. Genes Dev. 2006;20:543-56 pubmed
product information
master code :
ES002
SKU :
ES002
product name :
Mca-RPKPVE-Nval-WRK(Dnp)-NH2 Fluorogenic MMP Substrate
unit size :
1 mg
target :
Protease Substrates
category :
Activity Assays
purity :
>95%, by HPLC.
species :
Multi-Species
theoretical molecular weight :
1676 Da
details of functionality :
The peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2,4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence. It is an excellent substrate for MMP-3 (stromelysin 1) and MMP-10 (stromelysin 2). The cleavage site is the peptide bond between Glu and Nval (norvaline). It is also an excellent substrate for Trypsin, HGF activator and factor Xa.
applications :
Bioactivity, Binding Activity
extended description :
Substrate for MMP-3, MMP-10, Trypsin, HGF Activator, and Coagulation Factor X
USD :
281 USD
product details :
Substrate for MMP-3, MMP-10, Trypsin, HGF Activator, and Coagulation Factor X
storage :
Samples are stable for up to twelve months from date of receipt at -20░ C to -70░ C. The substrate can be aliquoted and stored -20░ C to -70░ C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.
more info or order :
R&D Systems product webpage
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.