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company name :
R&D Systems
product type :
other
product name :
Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
catalog :
ES001
quantity :
1 mg
price :
281 USD
more info or order :
citations: 28
Reference
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Op den Brouw B, Coimbra F, Casewell N, Ali S, Vonk F, Fry B. A Genus-Wide Bioactivity Analysis of Daboia (Viperinae: Viperidae) Viper Venoms Reveals Widespread Variation in Haemotoxic Properties. Int J Mol Sci. 2021;22: pubmed publisher
Ozols M, Eckersley A, Platt C, Stewart McGuinness C, Hibbert S, Revote J, et al. Predicting Proteolysis in Complex Proteomes Using Deep Learning. Int J Mol Sci. 2021;22: pubmed publisher
Bertran A, Khomiak D, Konopka A, Rejmak E, Bulska E, Seco J, et al. Design and synthesis of selective and blood-brain barrier-permeable hydroxamate-based gelatinase inhibitors. Bioorg Chem. 2020;94:103365 pubmed publisher
Jobin P, Solis N, Machado Y, Bell P, Kwon N, Kim S, et al. Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase. J Biol Chem. 2019;294:12866-12879 pubmed publisher
Dall M, Trammell S, Asping M, Hassing A, Agerholm M, Vienberg S, et al. Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity. J Biol Chem. 2019;294:13304-13326 pubmed publisher
Aristorena M, Gallardo Vara E, Vicen M, de Las Casas Engel M, Ojeda Fernandez L, Nieto C, et al. MMP-12, Secreted by Pro-Inflammatory Macrophages, Targets Endoglin in Human Macrophages and Endothelial Cells. Int J Mol Sci. 2019;20: pubmed publisher
Ye Y, Toczek J, Gona K, Kim H, Han J, Razavian M, et al. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Sci Rep. 2018;8:11647 pubmed publisher
Sylte I, Dawadi R, Malla N, von Hofsten S, Nguyen T, Solli A, et al. The selectivity of galardin and an azasugar-based hydroxamate compound for human matrix metalloproteases and bacterial metalloproteases. PLoS ONE. 2018;13:e0200237 pubmed publisher
Campagna J, Vadivel K, Jagodzinska B, Jun M, Bilousova T, Spilman P, et al. Evaluation of an Allosteric BACE Inhibitor Peptide to Identify Mimetics that Can Interact with the Loop F Region of the Enzyme and Prevent APP Cleavage. J Mol Biol. 2018;430:1566-1576 pubmed publisher
Rempe R, Hartz A, Soldner E, Sokola B, Alluri S, Abner E, et al. Matrix Metalloproteinase-Mediated Blood-Brain Barrier Dysfunction in Epilepsy. J Neurosci. 2018;38:4301-4315 pubmed publisher
Remacle A, Hullugundi S, Dolkas J, Angert M, Chernov A, Strongin A, et al. Acute- and late-phase matrix metalloproteinase (MMP)-9 activity is comparable in female and male rats after peripheral nerve injury. J Neuroinflammation. 2018;15:89 pubmed publisher
Qu F, Holloway J, Esterhai J, Burdick J, Mauck R. Programmed biomolecule delivery to enable and direct cell migration for connective tissue repair. Nat Commun. 2017;8:1780 pubmed publisher
Debono J, Dobson J, Casewell N, Romilio A, Li B, Kurniawan N, et al. Coagulating Colubrids: Evolutionary, Pathophysiological and Biodiscovery Implications of Venom Variations between Boomslang (Dispholidus typus) and Twig Snake (Thelotornis mossambicanus). Toxins (Basel). 2017;9: pubmed publisher
Wong E, Cohen T, Romi E, Levin M, Peleg Y, Arad U, et al. Harnessing the natural inhibitory domain to control TNFα Converting Enzyme (TACE) activity in vivo. Sci Rep. 2016;6:35598 pubmed publisher
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image
image 1 :
R&D Systems ES001 image 1
product information
master code :
ES001
SKU :
ES001
product name :
Mca-PLGL-Dpa-AR-NH2 Fluorogenic MMP Substrate
unit size :
1 mg
target :
Protease Substrates
category :
Activity Assays
immunogen :
, Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2
species :
Multi-Species
theoretical molecular weight :
1093 Da
details of functionality :
The peptide substrate contains a highly fluorescent 7-methoxycoumarin group that is efficiently quenched by resonance energy transfer to the 2, 4-dinitrophenyl group. It can be used to measure the activities of peptidases that are capable of cleaving an amide bond between the fluorescent group and the quencher group, causing an increase in fluorescence. It is also an excellent substrate for active Cathepsins D and E.
applications :
Bioactivity, Binding Activity
extended description :
Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, Cathepsin D, and Cathepsin E
USD :
281 USD
product details :
Substrate for MMP-1, MMP-2, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, MMP-14, MMP-15, MMP-16, Cathepsin D, and Cathepsin E
storage :
Samples are stable for up to twelve months from date of receipt at -20░ C to -70░ C. The substrate can be aliquoted and stored -20░ C to -70░ C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.