Recombinant Human Parkin pS65 Protein, CF | R&D Systems E3-166-025 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human Parkin pS65 Protein, CF

catalog :

E3-166-025

quantity :

25 ug

price :

559 USD

more info or order :

R&D Systems product webpage

citations: 3

Reference
Ardah M, Radwan N, Khan E, Kitada T, Haque M. Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination. Int J Mol Sci. 2023;24: pubmed publisher
Roverato N, Sailer C, Catone N, Aichem A, Stengel F, Groettrup M. Parkin is an E3 ligase for the ubiquitin-like modifier FAT10, which inhibits Parkin activation and mitophagy. Cell Rep. 2021;34:108857 pubmed publisher
Watzlawik J, Hou X, Fricova D, Ramnarine C, Barodia S, Gendron T, et al. Sensitive ELISA-based detection method for the mitophagy marker p-S65-Ub in human cells, autopsy brain, and blood samples. Autophagy. 2021;17:2613-2628 pubmed publisher

product information

master code :

E3-166

SKU :

E3-166-025

product name :

Recombinant Human Parkin pS65 Protein, CF

unit size :

25 ug

description :

The Recombinant Human Parkin pS65 Protein, CF from R&D Systems is derived from Sf 21 (baculovirus). The Recombinant Human Parkin pS65 Protein, CF has been validated for the following applications: Bioactivity.

target :

Parkin

category :

Proteins and Enzymes

buffer :

Supplied as a solution in Tris, NaCl, Glycerol, Brij-35 and TCEP.

conjugate :

Unconjugated

purity :

>90%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie« Blue stain.

species :

Human

theoretical molecular weight :

52 kDa

details of functionality :

Reaction conditions will need to be optimized for each specific application. Parkin pS65 has substantial ligase activity in the absence of added activators.

accessionNumbers :

O60260.2

applications :

Bioactivity

source long :

Spodoptera frugiperda , Sf 21 (baculovirus)-derived human Parkin protein Met1 - Val465

source short :

Sf 21 (baculovirus)

USD :

559 USD

alt names :

AR-JP, E3 ubiquitin ligase, E3 ubiquitin-protein ligase parkin, EC 6.3.2.-, LPRS2, PARK2, parkin, parkin 2, Parkinson disease protein 2, Parkinson juvenile disease protein 2, parkinson protein 2, E3 ubiquitin protein ligase (parkin), PDJ, PDJjuvenile) 2, parkin, PRKN

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage