Recombinant Human/Mouse/Rat UbcH7/UBE2L3 Protein, CF | R&D Systems E2-640-100 product information

product summary

company name :

R&D Systems

product type :

protein

product name :

Recombinant Human/Mouse/Rat UbcH7/UBE2L3 Protein, CF

catalog :

E2-640-100

quantity :

100 ug

price :

355 USD

more info or order :

R&D Systems product webpage

citations: 22

Reference
Radko Juettner S, Yue H, Myers J, Carter R, Robertson A, Mittal P, et al. Targeting DCAF5 suppresses SMARCB1-mutant cancer by stabilizing SWI/SNF. Nature. 2024;628:442-449 pubmed publisher
Chuong P, Statsyuk A. Selective Smurf1 E3 ligase inhibitors that prevent transthiolation. bioRxiv. 2023;: pubmed publisher
Ardah M, Radwan N, Khan E, Kitada T, Haque M. Parkin Precipitates on Mitochondria via Aggregation and Autoubiquitination. Int J Mol Sci. 2023;24: pubmed publisher
Du X, Pang J, Gu B, Si T, Chang Y, Li T, et al. A bio-orthogonal linear ubiquitin probe identifies STAT3 as a direct substrate of OTULIN in glioblastoma. Nucleic Acids Res. 2023;51:1050-1066 pubmed publisher
Yan C, Yang H, Su P, Li X, Li Z, Wang D, et al. OTUB1 suppresses Hippo signaling via modulating YAP protein in gastric cancer. Oncogene. 2022;41:5186-5198 pubmed publisher
Pirooznia S, Wang H, Panicker N, Kumar M, Neifert S, Dar M, et al. Deubiquitinase CYLD acts as a negative regulator of dopamine neuron survival in Parkinson's disease. Sci Adv. 2022;8:eabh1824 pubmed publisher
Yoon S, Bogdanov K, Wallach D. Site-specific ubiquitination of MLKL targets it to endosomes and targets Listeria and Yersinia to the lysosomes. Cell Death Differ. 2022;: pubmed publisher
Weston K, Gao X, Zhao J, Kim K, Maloney S, Gotoff J, et al. Identification of disease-linked hyperactivating mutations in UBE3A through large-scale functional variant analysis. Nat Commun. 2021;12:6809 pubmed publisher
Otten E, Werner E, Crespillo Casado A, Boyle K, Dharamdasani V, Pathe C, et al. Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection. Nature. 2021;594:111-116 pubmed publisher
Albert M, Brinkmann K, Pokrzywa W, Günther S, Kronke M, Hoppe T, et al. CHIP ubiquitylates NOXA and induces its lysosomal degradation in response to DNA damage. Cell Death Dis. 2020;11:740 pubmed publisher
Gatti M, Imhof R, Huang Q, Baudis M, Altmeyer M. The Ubiquitin Ligase TRIP12 Limits PARP1 Trapping and Constrains PARP Inhibitor Efficiency. Cell Rep. 2020;32:107985 pubmed publisher
Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts E, et al. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Nat Commun. 2019;10:1870 pubmed publisher
Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe P, et al. Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. Sci Rep. 2017;7:15050 pubmed publisher
French M, Klosowiak J, Aslanian A, Reed S, Yates J, Hunter T. Mechanism of ubiquitin chain synthesis employed by a HECT domain ubiquitin ligase. J Biol Chem. 2017;292:10398-10413 pubmed publisher
Zhang X, Li B, Rezaeian A, Xu X, Chou P, Jin G, et al. H3 ubiquitination by NEDD4 regulates H3 acetylation and tumorigenesis. Nat Commun. 2017;8:14799 pubmed publisher
He S, Cao Y, Xie P, Dong G, Zhang L. The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function. Sci Rep. 2017;7:41364 pubmed publisher
Lin S, Lu S, Mulaj M, Fang B, Keeley T, Wan L, et al. Monoubiquitination Inhibits the Actin Bundling Activity of Fascin. J Biol Chem. 2016;291:27323-27333 pubmed publisher
Pan Y, Li R, Meng J, Mao H, Zhang Y, Zhang J. Smurf2 negatively modulates RIG-I-dependent antiviral response by targeting VISA/MAVS for ubiquitination and degradation. J Immunol. 2014;192:4758-64 pubmed publisher
Lonskaya I, Desforges N, Hebron M, Moussa C. Ubiquitination increases parkin activity to promote autophagic ?-synuclein clearance. PLoS ONE. 2013;8:e83914 pubmed publisher
Hebron M, Lonskaya I, Sharpe K, Weerasinghe P, Algarzae N, Shekoyan A, et al. Parkin ubiquitinates Tar-DNA binding protein-43 (TDP-43) and promotes its cytosolic accumulation via interaction with histone deacetylase 6 (HDAC6). J Biol Chem. 2013;288:4103-15 pubmed publisher
Sun J, Zhou W, Kaliappan K, Nawaz Z, Slingerland J. ERα phosphorylation at Y537 by Src triggers E6-AP-ERα binding, ERα ubiquitylation, promoter occupancy, and target gene expression. Mol Endocrinol. 2012;26:1567-77 pubmed publisher
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product information

master code :

E2-640

SKU :

E2-640-100

product name :

Recombinant Human/Mouse/Rat UbcH7/UBE2L3 Protein, CF

unit size :

100 ug

description :

The Recombinant Human/Mouse/Rat UbcH7/UBE2L3 Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human/Mouse/Rat UbcH7/UBE2L3 Protein, CF has been validated for the following applications: Enzyme Activity.

target :

UbcH7/UBE2L3

category :

Proteins and Enzymes

buffer :

Supplied as a solution in HEPES, NaCl, TCEP and Glycerol.

conjugate :

Unconjugated

species :

Human, Mouse, Rat

theoretical molecular weight :

18 kDa

gene symbol :

UBE2L3

details of functionality :

Recombinant Human UbcH7/UBE2L3 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human UbcH7/UBE2L3 concentration of 0.1-1 ╡M.

accessionNumbers :

P68036.1

applications :

Enzyme Activity

source long :

E. coli -derived UbcH7/UBE2L3 protein Met1 - Asp154

source short :

E. coli

USD :

355 USD

alt names :

E2-F1, EC 6.3.2.19, L-UBC, UBCE7, UbcH7, UBCH7UbcM4, UbcM4, UBE2L3, Ubiquitin carrier protein L3, ubiquitin-conjugating enzyme E2 L3, Ubiquitin-conjugating enzyme E2-F1, ubiquitin-conjugating enzyme E2L 3, ubiquitin-conjugating enzyme UBCH7, Ubiquitin-protein ligase L3

storage :

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.

more info or order :

R&D Systems product webpage