This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human UbcH5c/UBE2D3 Protein, CF
catalog :
E2-627
quantity :
100 ug
price :
239 USD
citations: 33
Reference
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Ma P, Song N, Li Y, Zhang Q, Zhang L, Zhang L, et al. Fine-Tuning of Shh/Gli Signaling Gradient by Non-proteolytic Ubiquitination during Neural Patterning. Cell Rep. 2019;28:541-553.e4 pubmed publisher
Xie C, Tan M, Lin X, Wu D, Jiang Y, Tan Y, et al. The FBXW7-SHOC2-Raptor Axis Controls the Cross-Talks between the RAS-ERK and mTORC1 Signaling Pathways. Cell Rep. 2019;26:3037-3050.e4 pubmed publisher
Liu B, Yi J, Yang X, Liu L, Lou X, Zhang Z, et al. MDM2-mediated degradation of WRN promotes cellular senescence in a p53-independent manner. Oncogene. 2019;38:2501-2515 pubmed publisher
Donovan K, An J, Nowak R, Yuan J, Fink E, Berry B, et al. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. elife. 2018;7: pubmed publisher
Yao M, Zhou X, Zhou J, Gong S, Hu G, Li J, et al. PCGF5 is required for neural differentiation of embryonic stem cells. Nat Commun. 2018;9:1463 pubmed publisher
Liu J, Deng J, Zhu F, Li Y, Lu Z, Qin P, et al. The MtDMI2-MtPUB2 Negative Feedback Loop Plays a Role in Nodulation Homeostasis. Plant Physiol. 2018;176:3003-3026 pubmed publisher
Kim S, Kim H, Kim H, Kim D, Han J, Byeon H, et al. HSPA5 negatively regulates lysosomal activity through ubiquitination of MUL1 in head and neck cancer. Autophagy. 2018;14:385-403 pubmed publisher
Brickner J, Soll J, Lombardi P, Vågbø C, Mudge M, Oyeniran C, et al. A ubiquitin-dependent signalling axis specific for ALKBH-mediated DNA dealkylation repair. Nature. 2017;551:389-393 pubmed publisher
Bosshard M, Aprigliano R, Gattiker C, Palibrk V, Markkanen E, Backe P, et al. Impaired oxidative stress response characterizes HUWE1-promoted X-linked intellectual disability. Sci Rep. 2017;7:15050 pubmed publisher
Wang S, Juan J, Zhang Z, Du Y, Xu Y, Tong J, et al. Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Cell Death Dis. 2017;8:e3058 pubmed publisher
Xu Y, Zhang Z, Li J, Tong J, Cao B, Taylor P, et al. The ubiquitin-conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis. J Hematol Oncol. 2017;10:132 pubmed publisher
Bononi A, Giorgi C, Patergnani S, Larson D, Verbruggen K, Tanji M, et al. BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation. Nature. 2017;546:549-553 pubmed publisher
Gou L, Kang J, Dai P, Wang X, Li F, Zhao S, et al. Ubiquitination-Deficient Mutations in Human Piwi Cause Male Infertility by Impairing Histone-to-Protamine Exchange during Spermiogenesis. Cell. 2017;169:1090-1104.e13 pubmed publisher
Schunter S, Villa R, Flynn V, Heidelberger J, Classen A, Beli P, et al. Ubiquitylation of the acetyltransferase MOF in Drosophila melanogaster. PLoS ONE. 2017;12:e0177408 pubmed publisher
Pakdaman Y, Sanchez Guixé M, Kleppe R, Erdal S, Bustad H, Bjørkhaug L, et al. In vitro characterization of six STUB1 variants in spinocerebellar ataxia 16 reveals altered structural properties for the encoded CHIP proteins. Biosci Rep. 2017;37: pubmed publisher
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Luo S, Jing L, Zhao T, Li Y, Liu Z, Diao A. Ubiquitination and dynactin regulate TMEPAI lysosomal trafficking. Sci Rep. 2017;7:42668 pubmed publisher
He S, Cao Y, Xie P, Dong G, Zhang L. The Nedd8 Non-covalent Binding Region in the Smurf HECT Domain is Critical to its Ubiquitn Ligase Function. Sci Rep. 2017;7:41364 pubmed publisher
Kim J, Shin S, Seo J, Lee E, Jeong M, Lee M, et al. C-terminus of HSC70-Interacting Protein (CHIP) Inhibits Adipocyte Differentiation via Ubiquitin- and Proteasome-Mediated Degradation of PPARγ. Sci Rep. 2017;7:40023 pubmed publisher
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product information
brand :
R&D Systems, powered by Boston Biochem
master code :
E2-627
SKU :
E2-627-100
product name :
Recombinant Human UbcH5c/UBE2D3 Protein, CF
description :
The Recombinant Human UbcH5c/UBE2D3 Protein, CF from R&D Systems, powered by Boston Biochem is derived from E. coli. The Recombinant Human UbcH5c/UBE2D3 Protein, CF has been validated for the following applications: Enzyme Activity.
target :
UbcH5c / UBE2D3
category :
Proteins and Enzymes
unit size :
100 ug
buffer :
X mg/ml (X µM) in 50 mM HEPES pH 7.0, 200 mM NaCl, 10% Glycerol (v/v), 1 mM TCEP
conjugate :
Unconjugated
main entrez gene id :
7323
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie® Blue stain
species :
Human
theoretical molecular weight :
17 kDa
gene symbol :
UBE2D3
details of functionality :
Recombinant Human UbcH5c/UBE2D3 is a member of the Ubiquitin-conjugating (E2) enzyme family that receives Ubiquitin from a Ubiquitin-activating (E1) enzyme and subsequently interacts with a Ubiquitin ligase (E3) to conjugate Ubiquitin to substrate proteins. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human UbcH5c/UBE2D3 concentration of 0.1-1 µM.
catalog number base :
E2-627
accessionNumbers :
P61077
applications :
Enzyme Activity
source :
The Recombinant Human UbcH5c / UBE2D3 Protein, CF from R&D Systems, powered by Boston Biochem is derived from E. coli. The Recombinant Human UbcH5c / UBE2D3 Protein, CF has been validated for the following applications: Enzyme Activity.
USD :
239 USD
alt names :
E2(17)KB 3, E2(17)KB3, EC 6.3.2.19, MGC43926, MGC5416, UBC4/5, UBC5C, UBCH5C, UBE2D3, Ubiquitin carrier protein D3, ubiquitin-conjugating enzyme E2 D3, Ubiquitin-conjugating enzyme E2(17)KB 3, Ubiquitin-conjugating enzyme E2-17 kDa 3, ubiquitin-conjugating enzyme E2D 3 (homologous to yeast UBC4/5), ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast), Ubiquitin-protein ligase D3
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -70 °C as supplied. 3 months, -70 °C under sterile conditions after opening.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.