product summary
Loading...
company name :
R&D Systems
product type :
protein
product name :
Recombinant Human USP2 Catalytic Domain Protein, CF
catalog :
E-504-050
quantity :
50 ug
price :
190 USD
more info or order :
citations: 29
Reference
Mukhopadhyay U, Levantovsky S, Carusone T, Gharbi S, Stein F, Behrends C, et al. A ubiquitin-specific, proximity-based labeling approach for the identification of ubiquitin ligase substrates. Sci Adv. 2024;10:eadp3000 pubmed publisher
Pereira M, Ramalho T, Andrade W, Durso D, Souza M, Fitzgerald K, et al. The IRAK1/IRF5 axis initiates IL-12 response by dendritic cells and control of Toxoplasma gondii infection. Cell Rep. 2024;43:113795 pubmed publisher
ISBERG R, Kotewicz K, Zheng M, Kim S, Tai A. Sde Proteins Coordinate Ubiquitin Utilization and Phosphoribosylation to Promote Establishment and Maintenance of the Legionella Replication Vacuole. Res Sq. 2023;: pubmed publisher
Kochenova O, Mukkavalli S, Raman M, Walter J. Cooperative assembly of p97 complexes involved in replication termination. Nat Commun. 2022;13:6591 pubmed publisher
Wang X, Zheng F, Yi Y, Wang G, Hong L, McCollum D, et al. Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress. Nat Commun. 2022;13:5565 pubmed publisher
Pham T, Najy A, Kim H. E3 ligase HUWE1 promotes PDGF D-mediated osteoblastic differentiation of mesenchymal stem cells by effecting polyubiquitination of β-PDGFR. J Biol Chem. 2022;298:101981 pubmed publisher
Marshall R, Vierstra R. A trio of ubiquitin ligases sequentially drives ubiquitylation and autophagic degradation of dysfunctional yeast proteasomes. Cell Rep. 2022;38:110535 pubmed publisher
Zhou H, Zaher M, Walter J, Brown A. Structure of CRL2Lrr1, the E3 ubiquitin ligase that promotes DNA replication termination in vertebrates. Nucleic Acids Res. 2021;49:13194-13206 pubmed publisher
Otten E, Werner E, Crespillo Casado A, Boyle K, Dharamdasani V, Pathe C, et al. Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection. Nature. 2021;594:111-116 pubmed publisher
Harris L, Le Pen J, Scholz N, Mieszczanek J, Vaughan N, Davis S, et al. The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1. J Biol Chem. 2021;296:100246 pubmed publisher
McBride M, Mashtalir N, Winter E, Dao H, Filipovski M, D Avino A, et al. The nucleosome acidic patch and H2A ubiquitination underlie mSWI/SNF recruitment in synovial sarcoma. Nat Struct Mol Biol. 2020;27:836-845 pubmed publisher
Isobe Y, Okumura M, McGregor L, Brittain S, Jones M, Liang X, et al. Manumycin polyketides act as molecular glues between UBR7 and P53. Nat Chem Biol. 2020;: pubmed publisher
Okur M, Lee J, Osmani W, Kimura R, Demarest T, Croteau D, et al. Cockayne syndrome group A and B proteins function in rRNA transcription through nucleolin regulation. Nucleic Acids Res. 2020;48:2473-2485 pubmed publisher
Fottner M, Brunner A, Bittl V, Horn Ghetko D, Jussupow A, Kaila V, et al. Site-specific ubiquitylation and SUMOylation using genetic-code expansion and sortase. Nat Chem Biol. 2019;15:276-284 pubmed publisher
Liang Y, Dearnaley W, Alden N, Solares M, Gilmore B, Pridham K, et al. Correcting errors in the BRCA1 warning system. DNA Repair (Amst). 2019;73:120-128 pubmed publisher
Tonzi P, Yin Y, Lee C, Rothenberg E, Huang T. Translesion polymerase kappa-dependent DNA synthesis underlies replication fork recovery. elife. 2018;7: pubmed publisher
Khan Q, Pediaditakis P, Malakhau Y, Esmaeilniakooshkghazi A, Ashkavand Z, Sereda V, et al. CHIP E3 ligase mediates proteasomal degradation of the proliferation regulatory protein ALDH1L1 during the transition of NIH3T3 fibroblasts from G0/G1 to S-phase. PLoS ONE. 2018;13:e0199699 pubmed publisher
Blount J, Libohova K, Marsh G, Sutton J, Todi S. Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila. Sci Rep. 2018;8:8513 pubmed publisher
Nath S, Yu Z, Gipson T, Marsh G, Yoshidome E, Robins D, et al. Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. J Clin Invest. 2018;128:3630-3641 pubmed publisher
McLelland G, Goiran T, Yi W, Dorval G, Chen C, Lauinger N, et al. Mfn2 ubiquitination by PINK1/parkin gates the p97-dependent release of ER from mitochondria to drive mitophagy. elife. 2018;7: pubmed publisher
Sha Z, Schnell H, Ruoff K, Goldberg A. Rapid induction of p62 and GABARAPL1 upon proteasome inhibition promotes survival before autophagy activation. J Cell Biol. 2018;217:1757-1776 pubmed publisher
Huang E, To M, Tran E, Dionisio L, Cho H, Baney K, et al. A VCP inhibitor substrate trapping approach (VISTA) enables proteomic profiling of endogenous ERAD substrates. Mol Biol Cell. 2018;29:1021-1030 pubmed publisher
Liu X, Reitsma J, Mamrosh J, Zhang Y, Straube R, Deshaies R. Cand1-Mediated Adaptive Exchange Mechanism Enables Variation in F-Box Protein Expression. Mol Cell. 2018;69:773-786.e6 pubmed publisher
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher
Murray A, Varela F, Hyland T, Schoenbeck A, White J, Tanabe L, et al. Phosphorylation of the type II transmembrane serine protease, TMPRSS13, in hepatocyte growth factor activator inhibitor-1 and -2-mediated cell-surface localization. J Biol Chem. 2017;292:14867-14884 pubmed publisher
Lee Y, Chou T, Pittman S, Keith A, Razani B, Weihl C. Keap1/Cullin3 Modulates p62/SQSTM1 Activity via UBA Domain Ubiquitination. Cell Rep. 2017;19:188-202 pubmed publisher
Nguyen T, Li J, Lu C, Mamrosh J, Lu G, Cathers B, et al. p97/VCP promotes degradation of CRBN substrate glutamine synthetase and neosubstrates. Proc Natl Acad Sci U S A. 2017;114:3565-3571 pubmed publisher
Kamber Kaya H, Ditzel M, Meier P, Bergmann A. An inhibitory mono-ubiquitylation of the Drosophila initiator caspase Dronc functions in both apoptotic and non-apoptotic pathways. PLoS Genet. 2017;13:e1006438 pubmed publisher
Liang Q, Dexheimer T, Zhang P, Rosenthal A, Villamil M, You C, et al. A selective USP1-UAF1 inhibitor links deubiquitination to DNA damage responses. Nat Chem Biol. 2014;10:298-304 pubmed publisher
product information
master code :
E-504
SKU :
E-504-050
product name :
Recombinant Human USP2 Catalytic Domain Protein, CF
unit size :
50 ug
description :
The Recombinant Human USP2 Catalytic Domain Protein, CF from R&D Systems is derived from E. coli. The Recombinant Human USP2 Catalytic Domain Protein, CF has been validated for the following applications: Enzyme Activity.
target :
USP2
category :
Proteins and Enzymes
buffer :
Supplied as a solution in HEPES, NaCl, EDTA and DTT.
conjugate :
Unconjugated
purity :
>95%, by SDS-PAGE under reducing conditions and visualized by Colloidal Coomassie« Blue stain.
species :
Human
theoretical molecular weight :
40 kDa
gene symbol :
USP2
details of functionality :
Recombinant Human USP2 Catalytic Domain is a Ubiquitin-specific deconjugating enzyme. Reaction conditions will need to be optimized for each specific application. We recommend an initial Recombinant Human USP2 Catalytic Domain concentration of 1-5 nM.
accessionNumbers :
O75604.2
applications :
Enzyme Activity
source long :
E. coli -derived human USP2 protein Asn259 - Met605
source short :
E. coli
USD :
190 USD
alt names :
Deubiquitinating enzyme 2, EC 3.1.2.15, EC 3.4.19.12,41 kDa ubiquitin-specific protease, ubiquitin specific peptidase 2, ubiquitin specific protease 12, ubiquitin specific protease 2, ubiquitin specific protease 9, ubiquitin thioesterase 2, Ubiquitin thiolesterase 2, Ubiquitin-specific-processing protease 2, UBP41, UBP41ubiquitin carboxyl-terminal hydrolase 2, USP9
storage :
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. 6 months from date of receipt, -70 ░C as supplied. 3 months, -70 ░C under sterile conditions after opening.
more info or order :
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.