This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
R&D Systems
product type :
ELISA/assay
product name :
Human GDF-15 DuoSet ELISA
catalog :
DY957
quantity :
1 Kit (for 15 Plates)
price :
850 USD
citations: 49
Reference
Melero I, de Miguel Luken M, de Velasco G, Garralda E, Mart xed n Liberal J, Joerger M, et al. Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours. Nature. 2025;637:1218-1227 pubmed publisher
Edlinger C, Bannehr M, Lichtenauer M, Paar V, Jankowska P, Hauptmann L, et al. Growth Differentiation Factor 15 as a Marker for Chronic Ventricular Pacing. J Clin Med. 2024;13: pubmed publisher
L homme L, Sermikli B, Haas J, Fleury S, Quemener S, Guinot V, et al. Adipose tissue macrophage infiltration and hepatocyte stress increase GDF-15 throughout development of obesity to MASH. Nat Commun. 2024;15:7173 pubmed publisher
Chrysafi P, Valenzuela Vallejo L, Stefanakis K, Kelesidis T, Connelly M, Mantzoros C. Total and H-specific GDF-15 levels increase in caloric deprivation independently of leptin in humans. Nat Commun. 2024;15:5190 pubmed publisher
Tarabeih N, Kalinkovich A, Ashkenazi S, Cherny S, Shalata A, Livshits G. Relationships between Circulating Biomarkers and Body Composition Parameters in Patients with Metabolic Syndrome: A Community-Based Study. Int J Mol Sci. 2024;25: pubmed publisher
Fejzo M, Rocha N, Cimino I, Lockhart S, Petry C, Kay R, et al. GDF15 linked to maternal risk of nausea and vomiting during pregnancy. Nature. 2024;625:760-767 pubmed publisher
Fejzo M, Rocha N, Cimino I, Lockhart S, Petry C, Kay R, et al. Fetally-encoded GDF15 and maternal GDF15 sensitivity are major determinants of nausea and vomiting in human pregnancy. bioRxiv. 2023;: pubmed publisher
Wang D, Townsend L, DesOrmeaux G, Frangos S, Batchuluun B, Dumont L, et al. GDF15 promotes weight loss by enhancing energy expenditure in muscle. Nature. 2023;619:143-150 pubmed publisher
Kletzer J, Hecht S, Ramsauer S, Scharinger B, Kaufmann R, Kammler J, et al. A Story of PA/BSA and Biomarkers to Diagnose Pulmonary Hypertension in Patients with Severe Aortic Valve Stenosis-The Rise of IGF-BP2 and GDF-15. J Cardiovasc Dev Dis. 2023;10: pubmed publisher
Liu K, Liu B, Wittert G, Thompson C, Hutchison A, Heilbronn L. Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake. Obes Res Clin Pract. 2023;17:91-93 pubmed publisher
Ackermann M, Kamp J, Werlein C, Walsh C, Stark H, Prade V, et al. The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. EBioMedicine. 2022;85:104296 pubmed publisher
Hecht S, Boxhammer E, Kaufmann R, Scharinger B, Reiter C, Kammler J, et al. CT-Diagnosed Sarcopenia and Cardiovascular Biomarkers in Patients Undergoing Transcatheter Aortic Valve Replacement: Is It Possible to Predict Muscle Loss Based on Laboratory Tests?-A Multicentric Retrospective Analysis. J Pers Med. 2022;12: pubmed publisher
Patel S, Haider A, Alvarez Guaita A, Bidault G, El Sayed Moustafa J, Guiu Jurado E, et al. Combined genetic deletion of GDF15 and FGF21 has modest effects on body weight, hepatic steatosis and insulin resistance in high fat fed mice. Mol Metab. 2022;65:101589 pubmed publisher
Fowler E, van Venrooy E, Witt R, Jia X. A TGFβR inhibitor represses keratin-7 expression in 3D cultures of human salivary gland progenitor cells. Sci Rep. 2022;12:15008 pubmed publisher
Hou C, Tsui K, Chen S, Chang K, Sung H, Hsu S, et al. The Upregulation of Caffeic Acid Phenethyl Ester on Growth Differentiation Factor 15 Inhibits Transforming Growth Factor β/Smad Signaling in Bladder Carcinoma Cells. Biomedicines. 2022;10: pubmed publisher
Bekfani T, Bekhite M, Neugebauer S, Derlien S, Hamadanchi A, Nisser J, et al. Metabolomic Profiling in Patients with Heart Failure and Exercise Intolerance: Kynurenine as a Potential Biomarker. Cells. 2022;11: pubmed publisher
Maddala R, Ho L, Karnam S, Navarro I, Osterwald A, Stinnett S, et al. Elevated Levels of Growth/Differentiation Factor-15 in the Aqueous Humor and Serum of Glaucoma Patients. J Clin Med. 2022;11: pubmed publisher
Hou C, Tsui K, Chang K, Sung H, Hsu S, Lin Y, et al. Caffeic acid phenethyl ester inhibits the growth of bladder carcinoma cells by upregulating growth differentiation factor 15. Biomed J. 2021;: pubmed publisher
Heduschke A, Ackermann K, Wilhelm B, Mey L, Bonaterra G, Kinscherf R, et al. GDF-15 Deficiency Reduces Autophagic Activity in Human Macrophages In Vitro and Decreases p62-Accumulation in Atherosclerotic Lesions in Mice. Cells. 2021;10: pubmed publisher
Carreras Badosa G, Gómez Vilarrubla A, Mas Pares B, Xargay Torrent S, Prats Puig A, Puerto Carranza E, et al. Longitudinal association of the anti-inflammatory serum marker GDF-15 with serum IgA and IgG in apparently healthy children. Sci Rep. 2021;11:18215 pubmed publisher
Fazeli P, Bredella M, Pachón Peña G, Zhao W, Zhang X, Faje A, et al. The dynamics of human bone marrow adipose tissue in response to feeding and fasting. JCI Insight. 2021;6: pubmed publisher
Lashkari K, Teague G, Beattie U, Betts J, Kumar S, McLaughlin M, et al. Plasma biomarkers of the amyloid pathway are associated with geographic atrophy secondary to age-related macular degeneration. PLoS ONE. 2020;15:e0236283 pubmed publisher
Jehn U, Schütte Nütgen K, Henke U, Bautz J, Pavenstadt H, Suwelack B, et al. Prognostic Value of Growth Differentiation Factor 15 in Kidney Donors and Recipients. J Clin Med. 2020;9: pubmed publisher
Jirak P, Pistulli R, Lichtenauer M, Wernly B, Paar V, Motloch L, et al. Expression of the Novel Cardiac Biomarkers sST2, GDF-15, suPAR, and H-FABP in HFpEF Patients Compared to ICM, DCM, and Controls. J Clin Med. 2020;9: pubmed publisher
Luukkonen P, Dufour S, Lyu K, Zhang X, Hakkarainen A, Lehtimäki T, et al. Effect of a ketogenic diet on hepatic steatosis and hepatic mitochondrial metabolism in nonalcoholic fatty liver disease. Proc Natl Acad Sci U S A. 2020;117:7347-7354 pubmed publisher
De Paepe B, Verhamme F, De Bleecker J. The myokine GDF-15 is a potential biomarker for myositis and associates with the protein aggregates of sporadic inclusion body myositis. Cytokine. 2020;127:154966 pubmed publisher
Kleinertz H, Hepner Schefczyk M, Ehnert S, Claus M, Halbgebauer R, Boller L, et al. Circulating growth/differentiation factor 15 is associated with human CD56bright natural killer cell dysfunction and nosocomial infection in severe systemic inflammation. EBioMedicine. 2019;43:380-391 pubmed publisher
Song J, Merbs S, Sokoll L, Chan D, Zhang Z. A multiplex immunoassay of serum biomarkers for the detection of uveal melanoma. Clin Proteomics. 2019;16:10 pubmed publisher
Liu H, Lyu Y, Li D, Cui Y, Huang Y, Dai W, et al. Potential relation between soluble growth differentiation factor-15 and testosterone deficiency in male patients with coronary artery disease. Cardiovasc Diabetol. 2019;18:21 pubmed publisher
Tarabeih N, Shalata A, Trofimov S, Kalinkovich A, Livshits G. Growth and differentiation factor 15 is a biomarker for low back pain-associated disability. Cytokine. 2019;117:8-14 pubmed publisher
Liu X, Chi X, Gong Q, Gao L, Niu Y, Chi X, et al. Association of serum level of growth differentiation factor 15 with liver cirrhosis and hepatocellular carcinoma. PLoS ONE. 2015;10:e0127518 pubmed publisher
Tanno T, Lim Y, Wang Q, Chesi M, Bergsagel P, Matthews G, et al. Growth differentiating factor 15 enhances the tumor-initiating and self-renewal potential of multiple myeloma cells. Blood. 2014;123:725-33 pubmed publisher
Ambaglio I, Malcovati L, Papaemmanuil E, Laarakkers C, Della Porta M, Gallì A, et al. Inappropriately low hepcidin levels in patients with myelodysplastic syndrome carrying a somatic mutation of SF3B1. Haematologica. 2013;98:420-3 pubmed publisher
Cheng J, Chang H, Leung P. Wild-type p53 attenuates cancer cell motility by inducing growth differentiation factor-15 expression. Endocrinology. 2011;152:2987-95 pubmed publisher
Kluger H, Hoyt K, Bacchiocchi A, Mayer T, Kirsch J, Kluger Y, et al. Plasma markers for identifying patients with metastatic melanoma. Clin Cancer Res. 2011;17:2417-25 pubmed publisher
Forejtnikovà H, Vieillevoye M, Zermati Y, Lambert M, Pellegrino R, Guihard S, et al. Transferrin receptor 2 is a component of the erythropoietin receptor complex and is required for efficient erythropoiesis. Blood. 2010;116:5357-67 pubmed publisher
Roth P, Junker M, Tritschler I, Mittelbronn M, Dombrowski Y, Breit S, et al. GDF-15 contributes to proliferation and immune escape of malignant gliomas. Clin Cancer Res. 2010;16:3851-9 pubmed publisher
Huh S, Chung C, Sharma A, Robertson G. Macrophage inhibitory cytokine-1 regulates melanoma vascular development. Am J Pathol. 2010;176:2948-57 pubmed publisher
Strelau J, Strzelczyk A, Rusu P, Bendner G, Wiese S, Diella F, et al. Progressive postnatal motoneuron loss in mice lacking GDF-15. J Neurosci. 2009;29:13640-8 pubmed publisher
Finkenstedt A, Bianchi P, Theurl I, Vogel W, Witcher D, Wroblewski V, et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br J Haematol. 2009;144:789-93 pubmed publisher
Ding Q, Mracek T, Gonzalez Muniesa P, Kos K, Wilding J, Trayhurn P, et al. Identification of macrophage inhibitory cytokine-1 in adipose tissue and its secretion as an adipokine by human adipocytes. Endocrinology. 2009;150:1688-96 pubmed publisher
Lakhal S, Talbot N, Crosby A, Stoepker C, Townsend A, Robbins P, et al. Regulation of growth differentiation factor 15 expression by intracellular iron. Blood. 2009;113:1555-63 pubmed publisher
Ramirez J, Schaad O, Durual S, Cossali D, Docquier M, Beris P, et al. Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol. 2009;144:251-62 pubmed publisher
Zimmermann M, Fucharoen S, Winichagoon P, Sirankapracha P, Zeder C, Gowachirapant S, et al. Iron metabolism in heterozygotes for hemoglobin E (HbE), alpha-thalassemia 1, or beta-thalassemia and in compound heterozygotes for HbE/beta-thalassemia. Am J Clin Nutr. 2008;88:1026-31 pubmed
Tamary H, Shalev H, Perez Avraham G, Zoldan M, Levi I, Swinkels D, et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood. 2008;112:5241-4 pubmed publisher
Barbarotto E, Corallini F, Rimondi E, Fadda R, Mischiati C, Grill V, et al. Differential effects of chemotherapeutic drugs versus the MDM-2 antagonist nutlin-3 on cell cycle progression and induction of apoptosis in SKW6.4 lymphoblastoid B-cells. J Cell Biochem. 2008;104:595-605 pubmed
Secchiero P, Corallini F, Rimondi E, Chiaruttini C, di Iasio M, Rustighi A, et al. Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells. Blood. 2008;111:1287-94 pubmed
Tanno T, Bhanu N, Oneal P, Goh S, Staker P, Lee Y, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13:1096-101 pubmed
Zauli G, Rimondi E, Corallini F, Fadda R, Capitani S, Secchiero P. MDM2 antagonist Nutlin-3 suppresses the proliferation and differentiation of human pre-osteoclasts through a p53-dependent pathway. J Bone Miner Res. 2007;22:1621-30 pubmed
product information
master code :
DY957
SKU :
DY957
product name :
Human GDF-15 DuoSet ELISA
unit size :
1 Kit (for 15 Plates)
description :
The Human GDF-15 DuoSet ELISA from R&D Systems is a Solid Phase Sandwich ELISA that quantifies human GDF-15.
target :
GDF-15
category :
ELISAs
species :
Human
gene symbol :
GDF15
kit type :
Solid Phase Sandwich ELISA
elisaRange :
7.81 - 500 pg/mL
top caption :
Human GDF-15 ELISA Standard Curve
applications :
ELISA
USD :
850 USD
alt names :
GDF15, growth differentiation factor 15, growth/differentiation factor 15, Macrophage inhibitory cytokine 1, MIC-1, MIC-1NSAID-activated gene 1 protein, MIC1Prostate differentiation factor, NAG-1, NAG-1NSAID-regulated gene 1 protein, NSAID (nonsteroidal inflammatory drug)-activated protein 1, PDF, PDFGDF-15, PLAB, PLABNRG-1, Placental bone morphogenetic protein, Placental TGF-beta, PTGF-beta, PTGFBPTGF-beta
storage :
Store the unopened product at 2 - 8 ░C. Do not use past expiration date.
company information
R&D Systems
614 McKinley Place N.E.
Minneapolis, MN 55413
info@RnDSystems.com
https://www.rndsystems.com
800 343-7475
headquarters: USA
R&D Systems develops and manufactures high-quality proteins and serves as a world leader in immunoassays. R&D Systems also produces quality antibodies, antibody arrays, stem cell and cell culture products, and cell selection and detection products, serving the life science and diagnostics industry.